ID A0A182NSX0_9DIPT Unreviewed; 947 AA.
AC A0A182NSX0;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=Polyadenylate-binding protein {ECO:0008006|Google:ProtNLM};
OS Anopheles dirus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7168 {ECO:0000313|EnsemblMetazoa:ADIR010760-PA, ECO:0000313|Proteomes:UP000075884};
RN [1] {ECO:0000313|Proteomes:UP000075884}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WRAIR2 {ECO:0000313|Proteomes:UP000075884};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Walton C., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles dirus WRAIR2.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ADIR010760-PA}
RP IDENTIFICATION.
RC STRAIN=WRAIR2 {ECO:0000313|EnsemblMetazoa:ADIR010760-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the polyadenylate-binding protein type-1 family.
CC {ECO:0000256|ARBA:ARBA00008557}.
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DR AlphaFoldDB; A0A182NSX0; -.
DR STRING; 7168.A0A182NSX0; -.
DR EnsemblMetazoa; ADIR010760-RA; ADIR010760-PA; ADIR010760.
DR VEuPathDB; VectorBase:ADIR010760; -.
DR OrthoDB; 21912at2759; -.
DR Proteomes; UP000075884; Unassembled WGS sequence.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd12378; RRM1_I_PABPs; 1.
DR CDD; cd12379; RRM2_I_PABPs; 1.
DR CDD; cd12380; RRM3_I_PABPs; 1.
DR CDD; cd12381; RRM4_I_PABPs; 2.
DR Gene3D; 3.30.70.330; -; 6.
DR Gene3D; 1.10.1900.10; c-terminal domain of poly(a) binding protein; 1.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR036053; PABP-dom.
DR InterPro; IPR006515; PABP_1234.
DR InterPro; IPR002004; PABP_HYD.
DR InterPro; IPR034364; PABP_RRM1.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR045305; RRM2_I_PABPs.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR003954; RRM_dom_euk.
DR NCBIfam; TIGR01628; PABP-1234; 1.
DR PANTHER; PTHR24012:SF491; POLYADENYLATE-BINDING PROTEIN; 1.
DR PANTHER; PTHR24012; RNA BINDING PROTEIN; 1.
DR Pfam; PF00658; PABP; 1.
DR Pfam; PF00076; RRM_1; 6.
DR SMART; SM00517; PolyA; 1.
DR SMART; SM00360; RRM; 6.
DR SMART; SM00361; RRM_1; 5.
DR SUPFAM; SSF63570; PABC (PABP) domain; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 3.
DR PROSITE; PS51309; PABC; 1.
DR PROSITE; PS50102; RRM; 6.
PE 3: Inferred from homology;
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00176}.
FT DOMAIN 11..89
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 99..176
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 192..269
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 295..371
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 560..637
FT /note="PABC"
FT /evidence="ECO:0000259|PROSITE:PS51309"
FT DOMAIN 668..744
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 805..882
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT REGION 473..522
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 744..764
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 887..920
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 473..511
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 947 AA; 106488 MW; 2CAF8201FC0D5D4F CRC64;
MNPGAPNYQM ASLYVGDLHS DITEATLFEK FSSAGPVLSI RVCRDLITRR SLGYAYVNFQ
QPADAERALD TMNFDPIKGR PIRIMWSQRD PSLRKSGVGN VFIKNLDKKI DNKAMYDTFS
AFGNILSCKV AQDEKGQSKG YGFVHFETEE SANTSIDKVN GMLLNEKKVY VGRFISRKER
EKELGEKAKL FTNVYVKNFG EDMTEETLRD MFEKYGPITS HRVMMKDGKS RGFGFVAFES
PEAAERAVQE LNSKEQSDGK MLYVGRAQKK NERQMELKRR FEQLKMERLT RYHGVNLYVK
NLDDTIDDER LRKEFAPYGT ITSAKVMLDE GRSKGFGFVC FSAPDEATKA VTEMNGRIVG
SKPLYVALAQ RKEERKSHLA SQYIQRVNSL RMQHIGQVYQ QSGSYFMPTI AQPQRFYGPQ
VAPVRTAPRW SANAQVRPTA GNQNVAANAP AGAYPAMAAA HVANNQYRQA GNVRGGANQQ
APNAQSAQAA SAMRNSARPI TGQQTAANMQ ARPVAPQLAA GQTRAQNYKF TQSMRNPQVP
QPVPIPAQPV AQQAVIVKGQ EPLTASMLAA AQPAEQKQML GERLFPLIEN MYPTLAGKIT
GMLLEIDNSE LLHMLEHKES LTAKADEAVA VLQAHQKSDF KMLHVGRKQK RNERQTGQNA
KLTRYHGVNL YVKNLDDTID DERLRKEFAP YGTITSAKVM LEGGRSKGYG FVCFSAPNEA
TKAVTKMNGR IVGSKPLDVA LAQRKEERKS HLASKDHEKE LGKKEQGEKK FTVYVNFEER
MTTEVLICEL VNQQSVEEKS SGYTDLLLVQ NLDKTINSKA VHNTFSAFGS ILSCKVLQDE
EGKSKGNCIV QFDKKESVNT SIDKMNGLLL YGRKIYVSRF ISRKDREKKL GKKEPGKKDQ
KDEKDEKDEK DEKDEKDEKD EKVKLFPTVY VNFDESMTTE MLNEDIF
//
