ID   A0A182NTN5_9DIPT        Unreviewed;       488 AA.
AC   A0A182NTN5;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   RecName: Full=PWWP domain-containing protein {ECO:0000259|PROSITE:PS50812};
OS   Anopheles dirus.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=7168 {ECO:0000313|EnsemblMetazoa:ADIR011026-PA, ECO:0000313|Proteomes:UP000075884};
RN   [1] {ECO:0000313|Proteomes:UP000075884}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WRAIR2 {ECO:0000313|Proteomes:UP000075884};
RG   The Broad Institute Genomics Platform;
RA   Neafsey D.E., Walton C., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA   Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Anopheles dirus WRAIR2.";
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:ADIR011026-PA}
RP   IDENTIFICATION.
RC   STRAIN=WRAIR2 {ECO:0000313|EnsemblMetazoa:ADIR011026-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the HDGF family.
CC       {ECO:0000256|ARBA:ARBA00005309}.
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DR   AlphaFoldDB; A0A182NTN5; -.
DR   STRING; 7168.A0A182NTN5; -.
DR   EnsemblMetazoa; ADIR011026-RA; ADIR011026-PA; ADIR011026.
DR   VEuPathDB; VectorBase:ADIR011026; -.
DR   OrthoDB; 4271850at2759; -.
DR   Proteomes; UP000075884; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   CDD; cd05834; PWWP_HRP; 1.
DR   Gene3D; 2.30.30.140; -; 1.
DR   Gene3D; 1.20.930.10; Conserved domain common to transcription factors TFIIS, elongin A, CRSP70; 1.
DR   InterPro; IPR036218; HIVI-bd_sf.
DR   InterPro; IPR021567; LEDGF_IBD.
DR   InterPro; IPR000313; PWWP_dom.
DR   InterPro; IPR035441; TFIIS/LEDGF_dom_sf.
DR   PANTHER; PTHR12550; HEPATOMA-DERIVED GROWTH FACTOR-RELATED; 1.
DR   PANTHER; PTHR12550:SF49; JIL-1 ANCHORING AND STABILIZING PROTEIN, ISOFORM A; 1.
DR   Pfam; PF11467; LEDGF; 1.
DR   Pfam; PF00855; PWWP; 1.
DR   SMART; SM00293; PWWP; 1.
DR   SUPFAM; SSF140576; HIV integrase-binding domain; 1.
DR   SUPFAM; SSF63748; Tudor/PWWP/MBT; 1.
DR   PROSITE; PS50812; PWWP; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils}.
FT   DOMAIN          10..60
FT                   /note="PWWP"
FT                   /evidence="ECO:0000259|PROSITE:PS50812"
FT   REGION          146..266
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          465..488
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          287..314
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        146..176
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        194..209
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        218..249
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   488 AA;  54422 MW;  B0E9B13EDE55143D CRC64;
     MVASKKAFTI GDLVFAKVKG YPPWPAKITR IDKNKYNVYF YGTGETANIK KEDLFPYETS
     KEKFATEKIM KRKGFKEAIL QIESAMSGDD PSPVSDQSLA YDVVAVQSGI DDFGEQKMSI
     STAEASKATF NESLVSANST MMDTSKVKLE PEEKRVEDEN NSSSRPAVHM KRDNKPTPNV
     KSNVAARKSA AMAATPVTVT NNGAQKKTAG NHEGNGVEAD AVDPKEVVSR SGRKIKMKRF
     MDRDEEEGNS PAMAGPSAKK RAIRSPVKDK TVSTLATAKK LNAFDKIENE RLYVLKLERE
     LVELNLEIKS SVKLNSADPE RCVKLMEQYE KLAVTPTILK KNPNCVETMK RLRKYVGNAK
     AWNMGDKEKL KFDFQAQQIR QKAELIYEQF KTILGMSENS VPFWEAFREE VTKFEEATKH
     LTQEELYLLI DEADVMVKEG HNALTNDAGA ADHDDDAEDR TFELKQLTDG TEEPEPTAPA
     ESTTNAGD
//