ID   A0A182NU84_9DIPT        Unreviewed;       904 AA.
AC   A0A182NU84;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   08-NOV-2023, entry version 33.
DE   RecName: Full=GH18 domain-containing protein {ECO:0000259|PROSITE:PS51910};
OS   Anopheles dirus.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=7168 {ECO:0000313|EnsemblMetazoa:ADIR011226-PA, ECO:0000313|Proteomes:UP000075884};
RN   [1] {ECO:0000313|Proteomes:UP000075884}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WRAIR2 {ECO:0000313|Proteomes:UP000075884};
RG   The Broad Institute Genomics Platform;
RA   Neafsey D.E., Walton C., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA   Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Anopheles dirus WRAIR2.";
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:ADIR011226-PA}
RP   IDENTIFICATION.
RC   STRAIN=WRAIR2 {ECO:0000313|EnsemblMetazoa:ADIR011226-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 18 family. IDGF
CC       subfamily. {ECO:0000256|ARBA:ARBA00006606}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A182NU84; -.
DR   STRING; 7168.A0A182NU84; -.
DR   EnsemblMetazoa; ADIR011226-RA; ADIR011226-PA; ADIR011226.
DR   VEuPathDB; VectorBase:ADIR011226; -.
DR   OrthoDB; 2663738at2759; -.
DR   Proteomes; UP000075884; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008061; F:chitin binding; IEA:InterPro.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   CDD; cd02873; GH18_IDGF; 2.
DR   Gene3D; 3.10.50.10; -; 2.
DR   Gene3D; 3.20.20.80; Glycosidases; 2.
DR   InterPro; IPR011583; Chitinase_II.
DR   InterPro; IPR029070; Chitinase_insertion_sf.
DR   InterPro; IPR001223; Glyco_hydro18_cat.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   InterPro; IPR015520; IDGF.
DR   PANTHER; PTHR11177; CHITINASE; 1.
DR   PANTHER; PTHR11177:SF235; CHITINASE-LIKE PROTEIN IDGF1-RELATED; 1.
DR   Pfam; PF00704; Glyco_hydro_18; 2.
DR   SMART; SM00636; Glyco_18; 2.
DR   SUPFAM; SSF51445; (Trans)glycosidases; 2.
DR   SUPFAM; SSF54556; Chitinase insertion domain; 2.
DR   PROSITE; PS51910; GH18_2; 2.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           23..904
FT                   /note="GH18 domain-containing protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5008130386"
FT   DOMAIN          25..441
FT                   /note="GH18"
FT                   /evidence="ECO:0000259|PROSITE:PS51910"
FT   DOMAIN          488..904
FT                   /note="GH18"
FT                   /evidence="ECO:0000259|PROSITE:PS51910"
SQ   SEQUENCE   904 AA;  99525 MW;  429DB7E0594DF624 CRC64;
     MWVKKLGVTL LLLVASSQYV RSQQAKVLCY YDAANFLIEG LGKVSLADID TALPFCTHLV
     YGYAAIDVET NKAVSRQPNL DLDTGKGNYR TVTQLKSKFP SLKVLLGLGG YKFSEPSIKY
     LTLLESGAAR ITFINSVYSL LKTYGFDGVD LEWQFPMNKP KKVRSTLGGV WHGFKKVFSG
     DSVLDEKAEE HREEFTALLR ELKNAFRSDG YQLGITVLPH VNSSIFMDIP AIINYLDFVN
     IAAYDQQTAA RNKKEADHAA PLYELSDRVP GNNVDGQVRL WLTNNAPASK LIVSIPTFGR
     GWKMNGDSGI TGVPPLAADG PSNPGPQTQT EGFFSWAEVC AMLPNPSNTA LKGAEAPLRK
     VGDPTKRFGS YAFRLPDSNG EHGVWVSYED PETAGNKAGY VKAKNLGGIA INDLSYDDFR
     GSCAGEKFPI LRAAKYRLGR GSCQKFDRRS VRYCALLITM WSVRLGVLAL VLGLLGVTVR
     AQNATTGPKV LCYYDGSSSL KEGLGKVTVS DIELALPFCT HLIYGYAGIN AETYRVRSLN
     EDLDLDSGKG HYRAVTTLKK RYPGLKVFLS VGAYHDLGEE KPFEKYLTLL ESGGSRTAFV
     NSAYTLLKTY EFDGLDLAWQ FPQTKPKRIR GWTGKVWHGF KKLFTGDSVL DPKADEHREE
     FTALVRDLKN AFVHDRFQIG FTHLPHVNQS IFLDIPLLKD NVEYVNVAAY DQQTPERNPK
     EGDYTAPIYE PTERVQGNNV DDKVKAWNTL GTPLDKIVVG IAAYGRGWKL VGESGITGVP
     PIPADGPSPP GPYTAIPGFY SFGEVCAKLP HPGNVNLKGA EYPLRKIGDP TKRFGPYAYR
     NPDEIGADGI WVSYEDPESA GNKAAYVKAK GLGGISINDL SLDDFRGTCS GDRFPILRAA
     KYRL
//