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Database: UniProt
Entry: A0A182NV68_9DIPT
LinkDB: A0A182NV68_9DIPT
Original site: A0A182NV68_9DIPT 
ID   A0A182NV68_9DIPT        Unreviewed;       862 AA.
AC   A0A182NV68;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   03-JUL-2019, entry version 22.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|VectorBase:ADIR011569-PA};
OS   Anopheles dirus.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicoidea;
OC   Culicidae; Anophelinae; Anopheles.
OX   NCBI_TaxID=7168 {ECO:0000313|Proteomes:UP000075884, ECO:0000313|VectorBase:ADIR011569-PA};
RN   [1] {ECO:0000313|VectorBase:ADIR011569-PA}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WRAIR2 {ECO:0000313|VectorBase:ADIR011569-PA};
RA   Neafsey D.E., Walton C., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA   Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J.,
RA   Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A.,
RA   Ireland A., Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W.,
RA   Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S.,
RA   Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Anopheles dirus WRAIR2.";
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000075884}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WRAIR2 {ECO:0000313|Proteomes:UP000075884};
RG   The Broad Institute Genomics Platform;
RA   Neafsey D.E., Walton C., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA   Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J.,
RA   Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A.,
RA   Ireland A., Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W.,
RA   Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S.,
RA   Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Anopheles dirus WRAIR2.";
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|VectorBase:ADIR011569-PA}
RP   IDENTIFICATION.
RC   STRAIN=WRAIR2 {ECO:0000313|VectorBase:ADIR011569-PA};
RG   VectorBase;
RL   Submitted (JUN-2016) to UniProtKB.
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DR   VectorBase; ADIR011569-RA; ADIR011569-PA; ADIR011569.
DR   Proteomes; UP000075884; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd00155; RasGEF; 1.
DR   CDD; cd06224; REM; 1.
DR   Gene3D; 1.10.840.10; -; 1.
DR   InterPro; IPR000159; RA_dom.
DR   InterPro; IPR008937; Ras-like_GEF.
DR   InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR   InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR23113; PTHR23113; 1.
DR   Pfam; PF00788; RA; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   Pfam; PF00618; RasGEF_N; 1.
DR   SMART; SM00314; RA; 1.
DR   SMART; SM00147; RasGEF; 1.
DR   SMART; SM00229; RasGEFN; 1.
DR   SUPFAM; SSF48366; SSF48366; 1.
DR   SUPFAM; SSF54236; SSF54236; 1.
DR   PROSITE; PS50200; RA; 1.
DR   PROSITE; PS00720; RASGEF; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
DR   PROSITE; PS50212; RASGEF_NTER; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000075884};
KW   Guanine-nucleotide releasing factor {ECO:0000256|PROSITE-
KW   ProRule:PRU00168, ECO:0000256|SAAS:SAAS01081641};
KW   Reference proteome {ECO:0000313|Proteomes:UP000075884}.
FT   DOMAIN      170    297       N-terminal Ras-GEF. {ECO:0000259|PROSITE:
FT                                PS50212}.
FT   DOMAIN      342    603       Ras-GEF. {ECO:0000259|PROSITE:PS50009}.
FT   DOMAIN      759    849       Ras-associating. {ECO:0000259|PROSITE:
FT                                PS50200}.
FT   REGION       29     60       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A182NV68}.
FT   REGION      601    642       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A182NV68}.
FT   REGION      690    738       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A182NV68}.
FT   COMPBIAS    690    729       Polar. {ECO:0000256|MobiDB-lite:
FT                                A0A182NV68}.
SQ   SEQUENCE   862 AA;  95389 MW;  D9DC0422822047B5 CRC64;
     MFCPSNETLQ NLTEKTKLLA HKCTQQIRNS ASAHSDGATP AAAPAQHRDP AAAPVAADPQ
     GMKEPAGGLV AGVPLVDGAV AKSGLRCFCP CKGTLSKIMG RKYAAGKEGQ SQRTTKWYVK
     PTWRLWGEER EEDAIYTVYL KKVRYHRPTP SASSQDSDDE ISHLEWETVR VRFVKAATLS
     RLVDALATDD GELESTFVNV FLNTYRTFAQ PEKVLELLLD RYEKLHAEPA LLQPESLSDQ
     HKKTLVSVLH VWLDGFPEDW DTDNLQRLLA FTSKRLPKSE IHIKALNRYT HRLDKYSRIP
     PPLPWSNDYH DFADQFGGLC LTPAFRGPPS HLLNSYRFPN IPVKHFAEQL TRMDMELFKR
     LIPHQCLGAI WSNRDKHESS SVLATVTQFN AVSFRVISSV LIEPRLKPQE RALLISTWID
     IAQELRLLKN FSSLKAIISG LQSNAVYRLS KTWAVLPRDK LELYNELARI FSEDNNAWAQ
     REVLMREGTA KFADTVGEND RHLQKVFQKQ NTLISHGTIP YLGTFLTDLT MIHAAIPDTL
     QDGLINFDKR RKEFEVLAQI KLLQGAANTY HLPDDPLFDR WFASLLVLDE REAHTLSCSL
     EPAPEMTKRP PAAQHPGGGA GGGGGGGGTP GHKKSDSIAS NSSSGAGSQF YCDINSTSNA
     SYSSRNNSLD RDATPPNASI LSAASSVSSL SMDSTTSGSQ RSNHNGVGSV RTPQSNRSHQ
     TNGTVASRGG ANGSARDHET PIINGQLVQN SPLKSSSPDF YIIKVTYETE QVELDGIVLY
     KSIMLANNER TPQVIRNAML KLGLEGDPDR YTLAQVLPDK ELLLPNNANV YYAVNTAYNL
     NFILRPKKDT AGSNATVPTG RP
//
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