ID   A0A182P371_9DIPT        Unreviewed;       649 AA.
AC   A0A182P371;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   03-MAY-2023, entry version 29.
DE   RecName: Full=GDNF/GAS1 domain-containing protein {ECO:0000259|SMART:SM00907};
OS   Anopheles epiroticus.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=199890 {ECO:0000313|EnsemblMetazoa:AEPI001355-PA, ECO:0000313|Proteomes:UP000075885};
RN   [1] {ECO:0000313|Proteomes:UP000075885}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Epiroticus2 {ECO:0000313|Proteomes:UP000075885};
RG   The Broad Institute Genomics Platform;
RA   Neafsey D.E., Howell P., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA   Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Anopheles epiroticus epiroticus2.";
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:AEPI001355-PA}
RP   IDENTIFICATION.
RC   STRAIN=Epiroticus2 {ECO:0000313|EnsemblMetazoa:AEPI001355-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the GDNFR family.
CC       {ECO:0000256|ARBA:ARBA00005961}.
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DR   AlphaFoldDB; A0A182P371; -.
DR   STRING; 199890.A0A182P371; -.
DR   EnsemblMetazoa; AEPI001355-RA; AEPI001355-PA; AEPI001355.
DR   VEuPathDB; VectorBase:AEPI001355; -.
DR   OrthoDB; 2881564at2759; -.
DR   Proteomes; UP000075885; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR   InterPro; IPR016017; GDNF/GAS1.
DR   InterPro; IPR037193; GDNF_alpha.
DR   InterPro; IPR003438; GDNF_rcpt.
DR   PANTHER; PTHR10269; GDNF RECEPTOR ALPHA; 1.
DR   PANTHER; PTHR10269:SF12; GLIAL CELL LINE-DERIVED NEUROTROPHIC FAMILY RECEPTOR-LIKE, ISOFORM E; 1.
DR   Pfam; PF02351; GDNF; 2.
DR   SMART; SM00907; GDNF; 2.
DR   SUPFAM; SSF110035; GDNF receptor-like; 2.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        606..630
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          10..89
FT                   /note="GDNF/GAS1"
FT                   /evidence="ECO:0000259|SMART:SM00907"
FT   DOMAIN          116..197
FT                   /note="GDNF/GAS1"
FT                   /evidence="ECO:0000259|SMART:SM00907"
FT   REGION          239..260
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          289..324
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   649 AA;  72615 MW;  0D45AF245699CA9D CRC64;
     MSFIHFQSTC HLALDSCRDD QVCSSALKTV LMHCDQHRCN RNACMESLQS FYRSIHDDLS
     LDIAFCLCRK TPNRHDICMI AQEKLHPVCA QRPPESLLQQ SSSTGNGITY NAPPGCHAVA
     ELCREDEDCR ARLEVFEQSC AVDSVTKKCA GKTSACRQAM LGILGTPLRT TCACQGSDQQ
     QLYDCLGWQR LLWLNPCVVE SQKDFHLKRL AELGLLTTTT TMATTTTTTM RTTTTMRTTR
     VTQPPTLPPT KPKPVYRPKP TEMHTIETNY VETPDTRPET LVHNQNGVIE RSDLDRGHPH
     PMPDEYDRST GNRHQPVDSD GDDDDVAVRY GKEIYQRPDE QVLHVASTEV LEVETFAPTT
     VTTTTTEPTT TPVPIRYCVV QKSQQPDQLI AEGKSRRLYI LDDAECSELC TCAGGDSLAL
     TCHALCVPLA PCRTALAYYS HAAPAYQAFR GRCLCYSGRF ICMRPPPGEY QLPGGIFLLL
     GYSSTDEALL RPHTNLGVQD AVRALQQYVL QHIDNSTHCT LTLFNITEEN IILSIRLPLD
     PKLTPMQLLK MEKDQCTRIL ETISHQINTQ YVELSAHRLL SIFKMAEVQI VWPEVSSARR
     YATPSLTISL ITGVATVLLT VCGTLLPPFV RWNQHHLQRR LAVLSPAIT
//