ID   A0A182P6E4_9DIPT        Unreviewed;       991 AA.
AC   A0A182P6E4;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   03-MAY-2023, entry version 34.
DE   RecName: Full=Ig-like domain-containing protein {ECO:0000259|PROSITE:PS50835};
OS   Anopheles epiroticus.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=199890 {ECO:0000313|EnsemblMetazoa:AEPI002492-PA, ECO:0000313|Proteomes:UP000075885};
RN   [1] {ECO:0000313|Proteomes:UP000075885}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Epiroticus2 {ECO:0000313|Proteomes:UP000075885};
RG   The Broad Institute Genomics Platform;
RA   Neafsey D.E., Howell P., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA   Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Anopheles epiroticus epiroticus2.";
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:AEPI002492-PA}
RP   IDENTIFICATION.
RC   STRAIN=Epiroticus2 {ECO:0000313|EnsemblMetazoa:AEPI002492-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
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DR   AlphaFoldDB; A0A182P6E4; -.
DR   STRING; 199890.A0A182P6E4; -.
DR   EnsemblMetazoa; AEPI002492-RA; AEPI002492-PA; AEPI002492.
DR   VEuPathDB; VectorBase:AEPI002492; -.
DR   OrthoDB; 3669354at2759; -.
DR   Proteomes; UP000075885; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031683; F:G-protein beta/gamma-subunit complex binding; IEA:InterPro.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0007188; P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway; IEA:InterPro.
DR   CDD; cd00066; G-alpha; 1.
DR   Gene3D; 1.10.400.10; GI Alpha 1, domain 2-like; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR001408; Gprotein_alpha_I.
DR   InterPro; IPR001019; Gprotein_alpha_su.
DR   InterPro; IPR011025; GproteinA_insert.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR10218:SF227; G PROTEIN ALPHA I SUBUNIT; 1.
DR   PANTHER; PTHR10218; GTP-BINDING PROTEIN ALPHA SUBUNIT; 1.
DR   Pfam; PF00503; G-alpha; 1.
DR   PRINTS; PR00318; GPROTEINA.
DR   PRINTS; PR00441; GPROTEINAI.
DR   SMART; SM00275; G_alpha; 1.
DR   SUPFAM; SSF48726; Immunoglobulin; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF47895; Transducin (alpha subunit), insertion domain; 1.
DR   PROSITE; PS51882; G_ALPHA; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   4: Predicted;
KW   GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Transducer {ECO:0000256|ARBA:ARBA00023224};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        914..936
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          673..773
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
SQ   SEQUENCE   991 AA;  110177 MW;  36ACB08D9DD91C83 CRC64;
     MSLVRIGFGA GESGKSTIVK QMKIIHETGY SQEECEQYRP VVYSNTIQSL MAIIRAMGQL
     RIDFADPSKT DIARQFFTYA SATEEGELTP ELVSLMKKLW TDPGVQQCFS RSREYQLNDS
     AAYYLNSLDR ISQPNYIPTQ QDVLRTRVKT TGIVETHFSF KSIHFKMFDV GGQRSERKKW
     IHCFEGVTAI IFCVALSGYD LVLAEDEEMN RMIESMKLFD SICNSKWFVE TSIILFLNKK
     DLFEEKIVRS PLTICFPEYT GSNTYEEASS YIRMKFENLN RRKDQKEIYT HLTCATDTSN
     IQFVFDAVSD HVICTKLDRT LQYTKGDGHY IICVLLYAYM ASRCCWNGRV FRALLLAIPL
     ASAANLLTSF EVRHGYIYPP SVTVVEGEVM HLRLLVPMRE GDRCLYREPG SPIDIDVHGE
     SGDAPSKRTN GKLLRFGDAE CSIRVNPVHQ RDGGFWRLTL VRGTERVRGI TMVDVIERPT
     VPGAGSGSGS VVSALDEISP ERTEYCFVQR QSTVQDEGFG GSVVPMHERC HLPLSETDPT
     GAGVWSVIAG VQGQMREMNY GIQIENKEEH IVTAVHKELD YHVLSCTLLY TPLTLKFCRF
     VRLVDGLGLN VIPGIGTPRY GYIGAGFERN ECGLEILGPE GLDKGTWKCL LGYGDEKLTK
     VSGAIVDNSD ANPPLAIIGL EETVIAQNDT TASLLCNANK PIDYCWFRGP HSQFYSLSEK
     LTPERNDGHY WYSGIALSMG ECGITFGNLR DSEHAGQWHC YVGNGHISAL EVSATFQVRI
     SPSQMVGAAG DRVEARLNFP ALLGCDSIPR GTPLQYCRFV TPTGEAFSLN ENITTDRPVL
     ERFYSNPNHN LAKGSCSLVI ASVREEDFGH WICAGKIEGH PVEDIYEIVL QNRDGANKPE
     DGDPAGETLS AASISGMVIG AVVVVGGAVG VGYWHFRKRL HRQTQAANEE IQMRTISSLE
     APRSPTTEQR VSVISTSISE SSSSANSQTA L
//