ID   A0A182P6T6_9DIPT        Unreviewed;       567 AA.
AC   A0A182P6T6;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   24-JAN-2024, entry version 26.
DE   RecName: Full=Wntless-like transmembrane domain-containing protein {ECO:0000259|Pfam:PF06664};
OS   Anopheles epiroticus.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=199890 {ECO:0000313|EnsemblMetazoa:AEPI002636-PA, ECO:0000313|Proteomes:UP000075885};
RN   [1] {ECO:0000313|Proteomes:UP000075885}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Epiroticus2 {ECO:0000313|Proteomes:UP000075885};
RG   The Broad Institute Genomics Platform;
RA   Neafsey D.E., Howell P., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA   Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Anopheles epiroticus epiroticus2.";
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:AEPI002636-PA}
RP   IDENTIFICATION.
RC   STRAIN=Epiroticus2 {ECO:0000313|EnsemblMetazoa:AEPI002636-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   AlphaFoldDB; A0A182P6T6; -.
DR   STRING; 199890.A0A182P6T6; -.
DR   EnsemblMetazoa; AEPI002636-RA; AEPI002636-PA; AEPI002636.
DR   VEuPathDB; VectorBase:AEPI002636; -.
DR   OrthoDB; 5478455at2759; -.
DR   Proteomes; UP000075885; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015643; F:toxic substance binding; IEA:InterPro.
DR   InterPro; IPR040416; TMEM181.
DR   InterPro; IPR047843; WLS-like_TM.
DR   PANTHER; PTHR31918; TRANSMEMBRANE PROTEIN 181; 1.
DR   PANTHER; PTHR31918:SF1; TRANSMEMBRANE PROTEIN 181; 1.
DR   Pfam; PF06664; MIG-14_Wnt-bd; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        73..94
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        260..281
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        316..337
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        349..368
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        388..411
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        452..473
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        493..513
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          206..516
FT                   /note="Wntless-like transmembrane"
FT                   /evidence="ECO:0000259|Pfam:PF06664"
FT   REGION          545..567
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   567 AA;  64420 MW;  727A834A08BDFBB4 CRC64;
     MAASGASKPA EDASKLGYSY VTPAGMCLRL RQSLAQFSDL FSEFNKYIAP AYHHDRCERS
     VHMRLYSMNK REFATVFLAF FACFGLGIFI GLAGPPITVT SKVSGGSLAP NGTVSGEGAA
     SSTYLAHGPF VMRTPLLTTY SQQLWIIAKL TTGNADDELV DKKFHLSVQI EGLTVDHKPV
     PVYGGAHNGG RDVTNRTRHL SCSYEECDEF TVLHIGFLDY AHYIVTVQFY GLEAFHQRYG
     IRTVQFYFKS YNPAFTQIEI WFRFIFVLFT FIITCWFAHT LRKYPVADWS IEQNYPNPIF
     PLIFIANNWL PGIIDALLQT TFLCGILMFW LCVYHGLRQN ERKFLTFYLP KLIVVLPIWL
     CAVVLGIWEK CDELNDPTYS HFEDSENYQG LKVFVSIAGA MYLLYLGLLM LKAYSELRSM
     PYFGKLVVYV ETPTGFNDFA VFFPGADMRL KILTLLMLIV LSISLIVTMQ HFGFDTLEDN
     FIAQLYTSYK SSAQFMCFYG LLNFYLYAMA YVYSPSGPAV HEPIIAKDNP TFSMINDSDE
     EVMYGSDEES RRPLNSACRK GNDYDSD
//