ID A0A182P9Y3_9DIPT Unreviewed; 868 AA.
AC A0A182P9Y3;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Peptidase M28 domain-containing protein {ECO:0000259|Pfam:PF04389};
OS Anopheles epiroticus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=199890 {ECO:0000313|EnsemblMetazoa:AEPI003737-PA, ECO:0000313|Proteomes:UP000075885};
RN [1] {ECO:0000313|Proteomes:UP000075885}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Epiroticus2 {ECO:0000313|Proteomes:UP000075885};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Howell P., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles epiroticus epiroticus2.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AEPI003737-PA}
RP IDENTIFICATION.
RC STRAIN=Epiroticus2 {ECO:0000313|EnsemblMetazoa:AEPI003737-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the peptidase M28 family.
CC {ECO:0000256|ARBA:ARBA00010918}.
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DR AlphaFoldDB; A0A182P9Y3; -.
DR STRING; 199890.A0A182P9Y3; -.
DR EnsemblMetazoa; AEPI003737-RA; AEPI003737-PA; AEPI003737.
DR VEuPathDB; VectorBase:AEPI003737; -.
DR OrthoDB; 277019at2759; -.
DR Proteomes; UP000075885; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008235; F:metalloexopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd03875; M28_Fxna_like; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR048024; Fxna-like_M28_dom.
DR InterPro; IPR045175; M28_fam.
DR InterPro; IPR007484; Peptidase_M28.
DR PANTHER; PTHR12147:SF26; ENDOPLASMIC RETICULUM METALLOPEPTIDASE 1; 1.
DR PANTHER; PTHR12147; METALLOPEPTIDASE M28 FAMILY MEMBER; 1.
DR Pfam; PF04389; Peptidase_M28; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00023049};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..34
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 375..395
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 407..435
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 447..473
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 485..505
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 511..531
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 543..567
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 579..600
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 607..625
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 139..334
FT /note="Peptidase M28"
FT /evidence="ECO:0000259|Pfam:PF04389"
SQ SEQUENCE 868 AA; 97644 MW; C6E2D17C4B411B84 CRC64;
MPYAEGKKLL TYIFNLELLW CVLGPGVGIG IYFLTYWNWN SLPSGVHLAD ESHRSTDGRF
VAERALYDLG ALTSRGPRVA GSETNERFAV DLLHGAVATI ARAALPEYDV TYETQRVNGS
YILDYEDYPI TSYYRNVQNI VVSVVRRGSF SGKYLLLNAH FDSAVTSPGA GDDGTMVVVM
LELMRQLTQT AGSSMQHGVL FLFNGCEENT MQGAHGFVRG HPLAQSVAAF INLDVAANGG
REIMFQSGPN YPFLMAYYRD HVQRPYANTL GEEVFQMGLV PSFTDYETLS KQGGWPGLDF
ALSSYGYLYH TALDARETIS AGTLQHIGDN LLGLVRALSN ADELGSIRDH REGTAVFFDF
MHLFLVYYTE TTGMIVNIVL GVLSLALIIG TLFMIMRKEG AVGTNVLFEA GMALIVQTLS
IVLGAGLSVL VAVIFDACGR SMSWFTSTWL LFGLYFVPCI SGLTLGPFLY VHFRKIPFLH
DQGRVILFLH AQHCIYAFLL ITLSIGGIRS AFVLLFPIIF YCATTIINMI IQFRLRVWIY
VHLAGQLVPV IYFCTLTVTL FAVFVPMTGR SSNSSNPDLQ MALFSSLLAL LLVGLLTPFV
VLFRRKLFVF GTFLLMFLVT AIVAATPEGF PFRERTSPQR YYIFHQQRNF YWPNGTLRDS
GAIYYLHPQD RHTPALLQSE VPEWSAARLL GDECERELYC GIPFYINRYH RQSGSSYWLP
AVEPPIFPEQ VIFQFVSRES PAPGRHRLFF RVQGPSHMSL YVSPLAGRKL VGWSFSDRIP
PSGKRWNGQD VYFVNFFSGS LDLAPFTFYI EIEQEVGTGD SHFYLSVVAQ YMHHDTVYRA
REFQSLLNKM PNYAHTVAYP GYLESWIF
//
