ID A0A182PBH5_9DIPT Unreviewed; 1009 AA.
AC A0A182PBH5;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=Ion transport domain-containing protein {ECO:0000259|Pfam:PF00520};
OS Anopheles epiroticus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=199890 {ECO:0000313|EnsemblMetazoa:AEPI004280-PA, ECO:0000313|Proteomes:UP000075885};
RN [1] {ECO:0000313|Proteomes:UP000075885}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Epiroticus2 {ECO:0000313|Proteomes:UP000075885};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Howell P., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles epiroticus epiroticus2.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AEPI004280-PA}
RP IDENTIFICATION.
RC STRAIN=Epiroticus2 {ECO:0000313|EnsemblMetazoa:AEPI004280-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR AlphaFoldDB; A0A182PBH5; -.
DR STRING; 199890.A0A182PBH5; -.
DR EnsemblMetazoa; AEPI004280-RA; AEPI004280-PA; AEPI004280.
DR VEuPathDB; VectorBase:AEPI004280; -.
DR OrthoDB; 5476210at2759; -.
DR Proteomes; UP000075885; Unassembled WGS sequence.
DR GO; GO:0034703; C:cation channel complex; IEA:UniProt.
DR GO; GO:0005261; F:monoatomic cation channel activity; IEA:UniProt.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR PANTHER; PTHR47143:SF1; PWWP DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR47143; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL PROTEIN PAINLESS; 1.
DR Pfam; PF12796; Ank_2; 4.
DR Pfam; PF00520; Ion_trans; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 9.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 6.
DR PROSITE; PS50088; ANK_REPEAT; 6.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Sensory transduction {ECO:0000256|ARBA:ARBA00022606};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 574..597
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 672..689
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 701..727
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 739..761
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 807..827
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 210..242
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 311..344
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 346..378
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 379..404
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 413..447
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 448..480
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 584..836
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 925..959
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 967..1001
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1009 AA; 111806 MW; C93ED238BCBD99A1 CRC64;
MVREICQEWI TVIRSCAVAN VCGCVLVLVA GGSAPCSIRV TMENFGYKEG SSKPTRRLTA
KSMKRRNSQI PIKPRFSISP ELSAHWMNDQ EAMVTEDFEY MKIGPSPPAE SAPIIFDSYE
ESSPEFGIEL SSDSIRAALI EQLRLASGRV HLLDSIEQGN MVASNVVEFF GGASKTEKNI
CFLWAAFAKR WDLLDALMEH GSELAFHDTN GFTALHLSAF SGCLNCASVL VAKGIDVNLQ
PKAYTPLQCA AFGNAAHTAL FLLSKGARLE LCTRRPGGEE TLLHCAVRAN ALDCVRLFIA
EGMDVNSIKP SGMNAIHLAA DLGHVECLRV LLAAPGADPN IRIGIQESTA LHLAADEGNA
ACVALLLEQG AEARLKNHRG FTPLHLASRT SSLECVDLLL RAGSADPNEE DFDMRTPLHT
AIGRSESAFH IIETLICWGA DVNKKDVFGF TPLHLAALDG LAHCVEILLF YDADVTAKTK
KGTTALNVIT RKTPGSLAMI TQKFDDAMTL IHSQNPSEKE VELELDFRTI LQHCYPREIS
YLNTLVDEGQ KEMLQHPLCS AFIYIKWGKI RKYYIARLLF CFIFILFLTL YVLTALAHNC
YNGSKDMEET IQEQELCQKQ SILGNMLRRN PFVMEMQWLV LVAITFVEIC RKLYGITGYS
SIRRYVTQME NITEWFIIVS VFVISYIYTK RTYTWQNHIG AFAVLLGWTH LMVMIGQLPV
FGAYVAMYTK VQVEFAKLFI AYSCMLVGFT ISFCVIFPSS SSFENPFMGF ITVLVMMVGE
LDLELLINDP DGKDPPFMLE LSAQITFVLF LLFVTVILMN LLVGIAVDDI QALKKTATLS
KLVGQTKLIS YIESALFNGW LPNWLRSLLH YTALVSPRAY RVILSVKPLN PEEKRLPRNI
MMAAYEIAKE KEQQLAAVGE PVAVPTTAGE QPGAQPPGGP ESAPNSPEVD GAVPRTADTL
GALASKIDQS TEKMNDVTRE LQELRAVLKQ NQQLIDEIAR QVCSGPQKE
//
