ID   A0A182PBL8_9DIPT        Unreviewed;       655 AA.
AC   A0A182PBL8;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   RecName: Full=GATOR complex protein NPRL3 {ECO:0000256|RuleBase:RU368069};
DE   AltName: Full=Nitrogen permease regulator 3-like protein {ECO:0000256|RuleBase:RU368069};
OS   Anopheles epiroticus.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=199890 {ECO:0000313|EnsemblMetazoa:AEPI004323-PA, ECO:0000313|Proteomes:UP000075885};
RN   [1] {ECO:0000313|Proteomes:UP000075885}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Epiroticus2 {ECO:0000313|Proteomes:UP000075885};
RG   The Broad Institute Genomics Platform;
RA   Neafsey D.E., Howell P., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA   Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Anopheles epiroticus epiroticus2.";
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:AEPI004323-PA}
RP   IDENTIFICATION.
RC   STRAIN=Epiroticus2 {ECO:0000313|EnsemblMetazoa:AEPI004323-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- FUNCTION: As a component of the GATOR1 complex functions as an
CC       inhibitor of the amino acid-sensing branch of the TORC1 pathway.
CC       {ECO:0000256|RuleBase:RU368069}.
CC   -!- SUBCELLULAR LOCATION: Lysosome {ECO:0000256|RuleBase:RU368069}.
CC   -!- SIMILARITY: Belongs to the NPR3 family. {ECO:0000256|ARBA:ARBA00010546,
CC       ECO:0000256|RuleBase:RU368069}.
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DR   AlphaFoldDB; A0A182PBL8; -.
DR   STRING; 199890.A0A182PBL8; -.
DR   EnsemblMetazoa; AEPI004323-RA; AEPI004323-PA; AEPI004323.
DR   VEuPathDB; VectorBase:AEPI004323; -.
DR   OrthoDB; 8983at2759; -.
DR   Proteomes; UP000075885; Unassembled WGS sequence.
DR   GO; GO:1990130; C:GATOR1 complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0034198; P:cellular response to amino acid starvation; IEA:UniProtKB-UniRule.
DR   GO; GO:0032007; P:negative regulation of TOR signaling; IEA:InterPro.
DR   InterPro; IPR005365; Npr3.
DR   PANTHER; PTHR13153; CGTHBA PROTEIN -14 GENE PROTEIN; 1.
DR   PANTHER; PTHR13153:SF5; GATOR COMPLEX PROTEIN NPRL3; 1.
DR   Pfam; PF03666; NPR3; 2.
PE   3: Inferred from homology;
KW   Lysosome {ECO:0000256|RuleBase:RU368069};
KW   Signal {ECO:0000256|RuleBase:RU368069}.
FT   REGION          175..205
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          479..504
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          524..557
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        479..498
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        524..554
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   655 AA;  72005 MW;  BBDE9E4E4EE2B197 CRC64;
     MEVNPLSIIL VKSDSKGDRL LFRYPYTLPQ QFQTSVTPAR KTPYSLIHTG DDILQNAPPS
     NICFDQLYGI SDKDLATLFA VKPELCNQKF ELKVNDVRFV SHPTLLRSDP GSDQKSSDIQ
     INVVFALHAQ ASSSVVKSYY ELSKRIGIAL IYEERRDGYF SREIKTMVAV MDENSALQEQ
     EQPTGAAGTG GSAGTGSGTG PTGTSGQTVV TNATAAGIAV SVFDTILKNT TLAQFIKTIY
     HDLCTTGLLN VTMNQTVTLS FCLPQKAHQF HKKGTAVEPE TIDRCLESLK PYHGMLLLVD
     PSELFDCVPP SGANMLLQLI EVYNPLKSLQ NMASDAELLI DHVYQLVGHL VYWAKATIIY
     PLCETNVYVI APDAQLNIHS NLSDKFATKF PGMSLFEVIS DFSLPTSIGH LTTPLQHPAR
     QGRLAQMVLW MLQHHLLMQL HTYVQFVANL DGIEEEEFDA AGGRSSEDRV HALHALYGSS
     APSASSSQPL AVPTTGNRKH SLSEDRYSDS LSALLTTAAS AISNTRPSSA SHRSNISHSS
     VGGLQTASST DNDESIASID DDDKLKRLLA AFPEPDRKAV ARIPAASNPE DLALMVRLWK
     AGYFKGEHHL EEIMYFENLR RSQLLQLVDK FREVLIIYET EDPAIASLYS DQPVE
//