ID A0A182PES6_9DIPT Unreviewed; 3258 AA.
AC A0A182PES6;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=ABC transporter domain-containing protein {ECO:0000259|PROSITE:PS50893};
OS Anopheles epiroticus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=199890 {ECO:0000313|EnsemblMetazoa:AEPI005431-PA, ECO:0000313|Proteomes:UP000075885};
RN [1] {ECO:0000313|Proteomes:UP000075885}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Epiroticus2 {ECO:0000313|Proteomes:UP000075885};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Howell P., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles epiroticus epiroticus2.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AEPI005431-PA}
RP IDENTIFICATION.
RC STRAIN=Epiroticus2 {ECO:0000313|EnsemblMetazoa:AEPI005431-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR STRING; 199890.A0A182PES6; -.
DR EnsemblMetazoa; AEPI005431-RA; AEPI005431-PA; AEPI005431.
DR VEuPathDB; VectorBase:AEPI005431; -.
DR OrthoDB; 773084at2759; -.
DR Proteomes; UP000075885; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd03263; ABC_subfamily_A; 4.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC2_TM.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR026082; ABCA.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR19229:SF250; ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 3; 1.
DR PANTHER; PTHR19229; ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA; 1.
DR Pfam; PF12698; ABC2_membrane_3; 4.
DR Pfam; PF00005; ABC_tran; 4.
DR SMART; SM00382; AAA; 4.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 4.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 252..272
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 292..321
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 333..357
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 436..459
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 834..855
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1004..1024
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1044..1065
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1085..1107
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1114..1135
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1214..1240
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1857..1877
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1897..1922
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1942..1965
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1972..1990
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2044..2067
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2489..2510
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2660..2680
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2710..2727
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2739..2763
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2769..2791
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2874..2896
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 516..746
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 1286..1516
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 2123..2352
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 2943..3173
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT COILED 786..813
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 3258 AA; 366922 MW; 75A4EDE09F63350F CRC64;
MATSNWEKFV LLLWKNWILQ KRHYLQTLFE ILIPVLCCSI LLLVRGLVDP EFIDSNSVFK
PLETDRLTHL SKLAESKDFE FRIAYSPRSE LLEAIVQEAV RSLNVNDPQA RLAYVSYASA
REMESVLAGS SLLAGVEFDD SWADRSVVDG LPNNLTFAVR FPAELRDDEF QFSNWVTNLL
VVPFSPRLRN PLLEDGGSPS YYSEGFLGIQ GAISRALLGM RLPGVEMPPV HIQRYPYPPY
YDDAILEALQ QLLALIIIIS FFYTCINTVK YITIEKEKQL KEAMKIMGLS NWLHWSAWFV
KCLILLTVSL SLITILLCVP FSSAAIFENS DWTLIWVFFF VYSISTICFC FMVSVFFSKA
NTAAGIAGLL WFVTQLPFNV SQQNYDEMGT GAKVAMCLLS NSGMSLAMFL TVRLEATAAG
LRWSNLFEPA TIDDGFNVGI VIIMLLVDAV IYLLIALYIE QIMPGEFGIA RPWYFPFTKE
FWVRKQTPSR DTVLQGQEDA SRNRYIEQDP AGYAGVEIKQ LRKVYKGNKA AVDGLNLRMY
ENQISVLLGH NGAGKTTTMS MLTGVFSPTS GTALINGHDI RTDIDGVRSS LGLCPQHNVL
FDEMTVDEHL KFFSRLKGVP KQRVGEEIDR YLKLLELEDK RSAQSQTLSG GMKRKLAVGM
ALCGGSKVVL LDEPTSGMDP SARRALWNLL QKEKQNRTML LSTHFMDEAD VLGDRIAIMA
EGKLKAVGSP FFLKKTFGVG YRLICVKDAR CDKERLLSIL RKYIPDVTTD TDIGSELSFI
LKEEYIDVFQ RLLEDIEQQM ANALDRLHLL TGKELLWNQI QAQLLKKYLS SIRAWITLVM
MFVIPIFFVC MTFIITRSIS AGKDLPALEI TIDSYEKAIT VLDRTNGQPA RIEAFQKMFA
DHGGLVTIEE DMTEYIVRKS IEDIATVNTR YFVGATIATG TPYIGWFNNK AFHTAPLALN
LIYNAILQAQ CTECRLNVIN KPLPYRLDTQ LKKLNTGLNA GFQLAFNTGF AMAFVAALYI
MFYIKERTSR AKLLQFVSGT NVTLFWLLAF MWDFTLFVLN SLLYIATVAI FQEEGWSSFD
ELGRAFLLLL FFGFASLPVT YLFSFLFSVS ATGFVRMMFL NVLSGAIFFT AVNILKFDGI
DLNDVAEGLE WVFMFFPNFV LSHGLNNLNA ASSTASSCQK FCDLRGPACA VADLCAIDAR
CCDLEWFSFG KVGIVRNMLF CVLIGCVCFA LLFMLEYGVL QRLFHRKPKP GAVSAQSISS
ELDSDVLEEK RRIQKFNQTD IDGHNLLLRD VTKFYGNFQA VNNLSIGINH SECFGLLGIN
GAGKTTTFKM MTGDEEISSG NAWVKGISLR EDMNRAHRQI GYCPQFDALL EDLTGRETLR
IFALLRGVRK AEVKNVSYIL AEELNFTKHL DKRTKAYSGG NKRKLSTALA LLGNPSVVYL
DEPTTGMDPG AKRQFWDVIC KVRSTGKSIV LTSHSMEECE ALCTRLAIMV NGEFKCLGST
QHLKNKFSKG FLLTVKVARG STDAQQKRVA GVKDFVMSRF NGAVLKEEYE DSLTFHIPVT
DLKWSQMFGL MESSKQELEI EDYALGQTSL EQVFLFFTKY QRVTDSLDTS HTMATSRWSK
FVLLLWKNWI IQKRHYIQTV FEILIPVFCC AMLIVVRGLV DPEQVEKPTI FDRLAIGSLG
DLDLVFPPVT PNLAYSPQNE VLEKFMEDAL SEEVKSFRKV RLMPLENARE LESRLMQSNY
IGGIEFPDSY ANITELPQKL RYAIRLPGEL RFTGWTFGNW RTNFMVVPFV QGLRNANQSD
GGSPNYLREG FLTLQAAISR TFIRRQRADY DLPDVSLQRF PYPPYYEDLV LVAMERLLPM
IILISFFYTC INTVKFITIE KEKQLKEAMK IMGLPNWLHW TAWFVRCLIL LLITISLLVF
LISANLTSNT DLSVIEYADW SVLWFFFLTY ILVTICFCFM MSVFFNKANT AAGIAGLMWF
LFAIPFNITV QNYDEMAMGS KVASSLLSNT AMSFGIMNII RLEANQVGLQ WDNLFSSPSM
GDDFSVGLVM VMFVVDALLY LTIALYFEQV MPGEFGVAKP WNFLFTRDFW KRNRIEDGAA
SGGSKPEAGI YFEEEPSIDR AGVRIVNLRK VYGKKVAVEG LNLNMFDGQI TVLLGHNGAG
KTTTMSMLTG MFSPSAGTAL VNGYDIRKDI EGVRFSLGLC PQHNVLFNEL TVAEHLRFFA
QLKGVPGDKT AEEIDKYVSL LELTDKRNAQ SHTLSGGMKR KLGVGIALCG GSRVVLLDEP
TSGMDPSARR ALWDLIQQEK VGRTVILSTH FMDEADVLGD RIAIMAEGKL RAVGSPFFLK
KSLGAGYRLI CVKEPTCDKE RVLAILRKYI PEVRIETDIG TELSFVLRED YLKLFQPMLE
ELEDKMVSCG ISSYGISLTT MEEVFLRAGS DSNNGEHSVT QDGNGYIDMN DGSDIYSLDG
LTLLDGSKRL FQQIYAQFYK KFLTTVRSWI TLTMQMLIPI LFVLLSYLIF LNSNTGRDLP
ELKINLDGYT ASLTVLETAD GFESVTGAFR ERFRNEPYVH QLIVIDEDMS TFILNKSSQD
IATFNTRYWA GATLDSSVCT AWFNNKAYHS APLAVNLIYN ALLQSFCPDC ELQVSNKPLP
FRLDTQLQRL ETGANAGFQL AFNTGFAMAF VAALFILFYI KERTTRAKLL QFVSGVNVTL
FWAISFLWDY LVFVLSALCY IVTLAIIQQD GWSSFDQLGR VFLVLLFYAF ASLPVTYLFA
YLFHVPATGF VKMMLLNVLS GTIFFTAVSL LRFDGIDLQN VADVLEWIFL FFPSFSLTQS
MNALNMVGGR EALCQKACEQ ITICTEELKC ALVPQCCGTS AFTFDSQTGI NRNLLFFTGI
GVVSFAIILL VDYRVMKKIF CCRRTNAGMD MPDDRDGEMD SDVLEEKRRV AGSTEGELAS
YNLVLRELSK SYGKFVAVNK LSVGVRHSEC FGLLGINGAG KTSTFKMMTG DENITGGDAW
VNGINLRTDM NRVHKHIGYC PQFDALLEDL TGRETLHIFA LMRGVRRREI NGVSLTLAEE
LNFTKHLDKR TKAYSGGNKR KLSTALALLG NPAVVYLDEP TTGMDPGAKR QFWNVICKIR
NSGKSIVLTS HSMEECEALC TRLAIMVNGE FKCLGSTQHL KNKFSEGFLL TVKTKRTEPD
AAERVKSFVT SKFVGAVLKE EYQDSLTFHI ARTNQRWSAM FGLMETSKHE LGIEDYALGQ
TTLEQVFLFF TKYQRIVD
//