ID A0A182PEV4_9DIPT Unreviewed; 1584 AA.
AC A0A182PEV4;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=SH3 and multiple ankyrin repeat domains protein {ECO:0008006|Google:ProtNLM};
OS Anopheles epiroticus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=199890 {ECO:0000313|EnsemblMetazoa:AEPI005459-PA, ECO:0000313|Proteomes:UP000075885};
RN [1] {ECO:0000313|Proteomes:UP000075885}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Epiroticus2 {ECO:0000313|Proteomes:UP000075885};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Howell P., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles epiroticus epiroticus2.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AEPI005459-PA}
RP IDENTIFICATION.
RC STRAIN=Epiroticus2 {ECO:0000313|EnsemblMetazoa:AEPI005459-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR STRING; 199890.A0A182PEV4; -.
DR EnsemblMetazoa; AEPI005459-RA; AEPI005459-PA; AEPI005459.
DR VEuPathDB; VectorBase:AEPI005459; -.
DR OrthoDB; 2247290at2759; -.
DR Proteomes; UP000075885; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR041489; PDZ_6.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR24135:SF28; LD13733P; 1.
DR PANTHER; PTHR24135; SH3 AND MULTIPLE ANKYRIN REPEAT DOMAINS PROTEIN; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF17820; PDZ_6; 1.
DR SMART; SM00248; ANK; 6.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 2.
DR PROSITE; PS50088; ANK_REPEAT; 3.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT REPEAT 206..238
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 273..305
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 306..338
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 461..522
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 608..701
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 395..425
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 716..771
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 822..847
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 913..964
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1166..1271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1284..1330
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1384..1432
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 716..750
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 935..964
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1166..1199
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1235..1271
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1284..1308
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1395..1409
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1416..1432
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1584 AA; 170563 MW; 1E9BB6A8A12CE449 CRC64;
MSMIVIIIID DYIYILFIQK PAWNAGQLPS KPNSPTLGLR SRTNYPDGSR HCRALGHTRI
LAAGLESFQE EELKESFNYG LFSPPSNGKA GKFLDEERRL GDYPFNGPVG YLELKYKRRV
YKMLNLDERQ LKALHTRANL RRFIECINSG QVEKIAKMCA KGLDPNFHCQ ETGETPLTIA
TGSKKPNKLL IALVNGGALL DYRTRDGATA LHRAVERDSL EAVSTLLELG ASPNYRDTKG
LTPVYLSVTR KTDPKISEVL LHDHATLGIQ DSQGWQEVHQ ACRNGLVHHL EHLLFYGADM
DGQNASGNTP LHVCAVNNQE ACARMLLFRG ANRGALNYAN QTPYQVAVIA GNLELAEMIQ
NYKNEDIVPF RGPPRYNPRR RSGLGWGSTL SRIYGGPPSP CPSEHPFSSA SSSLSEGSSH
RSHEDDISIV TDKSLGDTSD IISDSSGVGT NSDSAACSIG HPSTTVVCME GYDAGLSGHI
HIQPGDVIEV VGSTDCGLLE GFVRGTNKTG FFPSSCVQEV QFRQKSIINV STSTPHHHYL
INTSSNEIVS HDLQQQLQQQ QQQQPSLLEQ QHIQQQYNSQ TAPRIKKSYV FNMFLRLRVM
RIIGEPRTVV LHRAKRGFGF ILRGAKASSP LMQLKPSPRC PALQYLDDVD PGGVADMAGL
KPGDFLLAIN SEDVTCASHE HVVDLIRNSG SLVSMTVVTL SQNLINSMML EASEIGSQHS
SGSGMSTPIS SRQCSTLPRR MNSGPSGTNC KQPAPMPPRR DPKTTLSVGR ARAKSMVAGL
EGGGEKGTDD DELLSATKST SAESIHQAQT QLLQAQQCHS AIGTPTQTGP GTPVQPRTAS
IKSRPTSSRI TAAELEELFQ RQQGADANRC SMLMSSSRFQ STGFDSGAGT PPISPQKGPI
VYASVAEMKR KKSSKAGMGT LKGRPIPIPQ IGSDLKRTFH STPDLASMSS SNQNEGTSSL
HYGSNSGAGS QLAINANGWY NTVGHKGHRS QDDMHSLHMS LQRLNLPPPN HPPPPPPVGQ
VVKVDVSRGS EYECLTALRK HIAQKAKVQS QVQEAEVMSS FKPASNAKLY ASPQDIRNVG
YRTVNVAGNN SSPSLTGSTS AMAAGNNSAS SCGINASNLN QNVELCKTGS LRSNASSTVS
VNSNNVAGST NNNVTTVTIS GNANGNVAAS STSTNQYAQP GRPGTDTQQQ VAQPQALYKS
PPNSAPPLPE PDYSLSESDP DEDNSVRLVR SHIKTNGDVK TTQNPGMAAE TSGNSNTSGS
STGSSSMPHS FSVEEIQKIR TKLKSSKSYP NDFLRQQNSQ TSQPSGEHGA SGGVPHEEGD
NSSSGVSSDQ EITITCNDTI KQPKSSFPKQ MVGTIGLKVN ASTSNQDTSG IRPSDSKKVT
LQLGATTESK LKHNNNNNLS ERRSDAEDND DADQDGTDSP SPPATGFQRH NSLTRKQAAT
IAANRAKANQ QNLQQRHAVT LATLPPPIEA ADSDEADSWS HPLQSSVGDS AAQLVEHAGM
VVLAPPPEFS DSTAILLRPL RFQVVLVSTY KHIIHINIRI SIISINMSII ITNIQEAVDH
LDLVVTIQIA SVSVLLELYR RLIA
//
