ID   A0A182PF10_9DIPT        Unreviewed;       696 AA.
AC   A0A182PF10;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   RecName: Full=Kazal-like domain-containing protein {ECO:0000259|PROSITE:PS51465};
OS   Anopheles epiroticus.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=199890 {ECO:0000313|EnsemblMetazoa:AEPI005515-PA, ECO:0000313|Proteomes:UP000075885};
RN   [1] {ECO:0000313|Proteomes:UP000075885}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Epiroticus2 {ECO:0000313|Proteomes:UP000075885};
RG   The Broad Institute Genomics Platform;
RA   Neafsey D.E., Howell P., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA   Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Anopheles epiroticus epiroticus2.";
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:AEPI005515-PA}
RP   IDENTIFICATION.
RC   STRAIN=Epiroticus2 {ECO:0000313|EnsemblMetazoa:AEPI005515-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR   AlphaFoldDB; A0A182PF10; -.
DR   STRING; 199890.A0A182PF10; -.
DR   EnsemblMetazoa; AEPI005515-RA; AEPI005515-PA; AEPI005515.
DR   VEuPathDB; VectorBase:AEPI005515; -.
DR   OrthoDB; 55673at2759; -.
DR   Proteomes; UP000075885; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:InterPro.
DR   CDD; cd00104; KAZAL_FS; 1.
DR   Gene3D; 3.30.60.30; -; 1.
DR   InterPro; IPR002350; Kazal_dom.
DR   InterPro; IPR036058; Kazal_dom_sf.
DR   InterPro; IPR039932; Spink4-like.
DR   PANTHER; PTHR21179:SF0; SERINE PROTEASE INHIBITOR KAZAL-TYPE 4; 1.
DR   PANTHER; PTHR21179; SERINE-TYPE ENDOPEPTIDASE INHIBITOR; 1.
DR   Pfam; PF07648; Kazal_2; 1.
DR   SMART; SM00280; KAZAL; 1.
DR   SUPFAM; SSF100895; Kazal-type serine protease inhibitors; 1.
DR   PROSITE; PS51465; KAZAL_2; 1.
PE   4: Predicted;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           18..696
FT                   /note="Kazal-like domain-containing protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5008131296"
FT   DOMAIN          633..690
FT                   /note="Kazal-like"
FT                   /evidence="ECO:0000259|PROSITE:PS51465"
FT   REGION          254..332
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          373..419
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          584..636
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        272..291
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        303..332
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        384..407
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        584..633
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   696 AA;  76387 MW;  99B1D713FB4A4B5C CRC64;
     MRSLWVFLLV AAPLVLAEDK LKKPSPIAAP TVATSSKHAD SVASPSMTEY KKTLIRKPKR
     SNGEIPLLII RPVDKRRKIY FKEPTVKIAS GGVATYGTYP ELHTNDGEMF TLEHMLPILS
     LEGMLKGFSK HGPNHFVPSP QFKPSDIHHL VSPQKTKEEY HHQLAPLKPS QLLSISHKPA
     EAVPAQTLPS PPPPNYVPAV NSEDQLLKLG QPQPSFSPLV QDKPAFVKPE QLPASFNFKV
     QEEVGHYKVN AIPLSKPSDV HHHPAPHHHY PQSTGGATSY VGSQGKPQPQ SQPLYIHAAA
     APSSDHPSSS SSSSSSSNKW QEVPKKPQVS VSTSFYHPKT IVTEQEHTKA YAQTQQAPQQ
     QPTVQTHLSY YFPKEESSPQ QPPAHHVHGH QSATSYSNVQ ASGSGPTGEH PADTPAEKPI
     HKTYSSHIKQ KYQKQHHQQP HVFIQKYFEF PSKSGVHQKN VVSEFHGSHG NETSEHQHLP
     EPQAYAAPQY LPLPQPQALH QPQHAVTGPG AQTLHLQLHH PVHHPVHHPM HHGGPAQSYW
     KFGRRTQDAA QVKPVVEHTN EPDHHDSQHA ASGAVLRQVK HTTVTIGSST EPSTAAGKDS
     KDGQPQAQDR IDQGAQQSGN GTASTSAPTR TPKQIQHGCE RRCIRNTVAQ AYEPVCGTDG
     VTYSNRGKLR CARTCGNDEL EIRSYGECTG ATSRNA
//