ID   A0A182PFY2_9DIPT        Unreviewed;       781 AA.
AC   A0A182PFY2;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   RecName: Full=EGF-like domain-containing protein {ECO:0000259|PROSITE:PS50026};
OS   Anopheles epiroticus.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=199890 {ECO:0000313|EnsemblMetazoa:AEPI005841-PA, ECO:0000313|Proteomes:UP000075885};
RN   [1] {ECO:0000313|Proteomes:UP000075885}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Epiroticus2 {ECO:0000313|Proteomes:UP000075885};
RG   The Broad Institute Genomics Platform;
RA   Neafsey D.E., Howell P., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA   Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Anopheles epiroticus epiroticus2.";
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:AEPI005841-PA}
RP   IDENTIFICATION.
RC   STRAIN=Epiroticus2 {ECO:0000313|EnsemblMetazoa:AEPI005841-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A182PFY2; -.
DR   STRING; 199890.A0A182PFY2; -.
DR   EnsemblMetazoa; AEPI005841-RA; AEPI005841-PA; AEPI005841.
DR   VEuPathDB; VectorBase:AEPI005841; -.
DR   OrthoDB; 5491728at2759; -.
DR   Proteomes; UP000075885; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   Gene3D; 2.10.25.10; Laminin; 7.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR013111; EGF_extracell.
DR   PANTHER; PTHR11219; TENEURIN AND N-ACETYLGLUCOSAMINE-1-PHOSPHODIESTER ALPHA-N-ACETYLGLUCOSAMINIDASE; 1.
DR   PANTHER; PTHR11219:SF73; TENEURIN-A; 1.
DR   Pfam; PF07974; EGF_2; 4.
DR   SMART; SM00181; EGF; 8.
DR   SUPFAM; SSF57196; EGF/Laminin; 3.
DR   PROSITE; PS00022; EGF_1; 4.
DR   PROSITE; PS01186; EGF_2; 4.
DR   PROSITE; PS50026; EGF_3; 3.
PE   4: Predicted;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW   ProRule:PRU00076}; EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        98..119
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          459..495
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          497..529
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          661..696
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   REGION          1..36
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          155..213
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        155..187
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        485..494
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        519..528
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        665..675
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        686..695
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ   SEQUENCE   781 AA;  85816 MW;  9CC51D4584958BD2 CRC64;
     LQSSQQLQQQ HQQQQQQQHQ QHQQQQLQSQ QQPIPQLAQS MTNTHITTSS RLGGSSSLVM
     PVFPLRTGGT AHTPHYSPYS PSRFRIDKSC QHRCSWKCFS IALILVTIIL SATLTYFAAT
     SSMKSNLDSA NCILVQDVKT GTAVDQTGTP IDTSNYGLLS GPSTLNPTEE SPITSTLDHN
     SFSTLGGGSA PPAGGNAALS TYSRRPAGQP DLPHQVQQHQ QQQQTTQIFT SVHQQKWPAI
     VELREFNEVH RSTIAPFQFW NVEFRNKHPA FIQFNFTLPW GANFAIYGRR NVGPTVTQYD
     FVEFIKGGRV DHKLRRKRSI GGSSFFQNDL LDAHFSGNEE NASAFETVRR NQYAFEDLTL
     DEVEKHIISK RSADGGTVGG GPSSSLQKID LEAMTVNVTI LQYLDIGRWY LSVYNDELLP
     HTVSLVVGEA EGVHTACPSD CSGRGSCYLG KCDCIDGYQG NDCSISVCPV LCSAHGHYGG
     GVCHCEEGWK GSECDIPVSE CEMPTCSNHG RCIEGDCHCE RGWKGLFCEQ QDCIDHSCSG
     HGTCVSGQCF CKAGWQGDDC SIVDQQVYQC LPGCSDHGTY DLDTGSCICD RHWTGIDCSQ
     AVCSLDCGPN GICENGRCRC DDGWTGSLCD QLMCDPRCAE HGQCKNGTCV CSQGWNGRHC
     TLPGCVNGCS RHGQCTMEDG EYKCICVEGW AGNDCSIALE MSCKDNIDND NDGMTDCSDS
     ECCVHSICAE HIMCLASNDP VEVLLRKQPP SVTASFYQRV KFLIEENSVQ SYAHMDEYSE
     R
//