ID   A0A182PIJ0_9DIPT        Unreviewed;      1097 AA.
AC   A0A182PIJ0;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   24-JAN-2024, entry version 30.
DE   RecName: Full=Importin N-terminal domain-containing protein {ECO:0000259|PROSITE:PS50166};
OS   Anopheles epiroticus.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=199890 {ECO:0000313|EnsemblMetazoa:AEPI006752-PA, ECO:0000313|Proteomes:UP000075885};
RN   [1] {ECO:0000313|Proteomes:UP000075885}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Epiroticus2 {ECO:0000313|Proteomes:UP000075885};
RG   The Broad Institute Genomics Platform;
RA   Neafsey D.E., Howell P., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA   Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Anopheles epiroticus epiroticus2.";
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:AEPI006752-PA}
RP   IDENTIFICATION.
RC   STRAIN=Epiroticus2 {ECO:0000313|EnsemblMetazoa:AEPI006752-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR   AlphaFoldDB; A0A182PIJ0; -.
DR   STRING; 199890.A0A182PIJ0; -.
DR   EnsemblMetazoa; AEPI006752-RA; AEPI006752-PA; AEPI006752.
DR   VEuPathDB; VectorBase:AEPI006752; -.
DR   OrthoDB; 22606at2759; -.
DR   Proteomes; UP000075885; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR000357; HEAT.
DR   InterPro; IPR021133; HEAT_type_2.
DR   InterPro; IPR001494; Importin-beta_N.
DR   InterPro; IPR040122; Importin_beta.
DR   PANTHER; PTHR10527; IMPORTIN BETA; 1.
DR   PANTHER; PTHR10527:SF6; IMPORTIN-4; 1.
DR   Pfam; PF02985; HEAT; 1.
DR   Pfam; PF03810; IBN_N; 1.
DR   SMART; SM00913; IBN_N; 1.
DR   SUPFAM; SSF48371; ARM repeat; 2.
DR   PROSITE; PS50077; HEAT_REPEAT; 1.
DR   PROSITE; PS50166; IMPORTIN_B_NT; 1.
PE   4: Predicted;
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          19..87
FT                   /note="Importin N-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS50166"
FT   REPEAT          394..431
FT                   /note="HEAT"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
SQ   SEQUENCE   1097 AA;  122343 MW;  51E96114428B802B CRC64;
     MEQIIKNLLV ADNDLIQQAS AELKEAFKKP ETIPQLCEVC VSNPDPQVRQ YAAMLLKKHL
     GKLRTWREVP AETQAIIKKG MLDAIVNESE KSVRNAITGF VGVLVKHEAE KEDGWMGEVL
     KFMFESTSSS DPKVSELGSS VFATLTDVAP DQFMPHIAMV CQLFSNALMA TEAGGNMATP
     VMYNILLGMS HLVPFIPGRQ EVEQTYQDSI PYVLKALSAF AEQDSFKFIE AFDILEVLAD
     ESPRTLSPHM KLLIDFSIQL AGNTQLEDSV RVKTITYIGW LVRLKKKMII KQKLVEPIVN
     ALFALMSVAP DVEDEDEEYF GSNEVSTPST CATQSLDVLA LHIPPKQLFP PLMALLEPAL
     AGDNPLPKKA AYLSIAVIAE GCSEHICSKY LRVLVDVIKR GITDENVMIR NAALFALGQF
     SEHLQPEISQ HADEILPILF EFLQQLCLQI RSGGKEPPHI DRVFYALETT CENLEDQVTP
     YLPMLMERLF ESLDSRNSVH LRELSLTTIA ATASAAKEHM LPYFPRLIDC LKLYLVKTDD
     EDICTLRPQA IDTFAALVRT IGKDNFLPLA VDTLNMGLTM MDESNDPDLR RSCYNLFASM
     ASSVKEDMAG SLNKIVETML ESVRSSEGIV PTFKDGTGDD MPVLPNGAMA GTNGSGEGDD
     EDEEFDIENS IGDEEEDEED IAGYSIENAY MDEKEEAILA LMEFAEHTGP AFAPFIQTAF
     EEIYKLLNHP NEDIRKASID AVKQFVVALH QLSNMEGVNQ TILLLIPKLS EIIRTDEERT
     VVMSALDGFS DILQEVGAAT FQADGQKDAV FNCIVDVLNG KVACQFDEPV DEEQEESEYD
     EAILESAGDI LPKFGRALPA EEFAVYFGRV WPYFIQKIEK TKQKDETSDS QRAFAIGVLA
     ECFEGLKEYT RNWLDSLLPL FLSCVQDRNN EVRSNSVYGL GEMVKHGKDC TFGHYPQIMA
     ALSQLVPKEQ HPGTLDNLCG ALARLIITNC SLVPLKSVLP VFVEYLPLRE DFTENLAVFQ
     CLDLLYKQGD ENLIPVLCRV LVVGLQVLYK KEYETDECRE LVHNLVKQSS KDFPEQFSKV
     ISSSSEVAEF VQTLSLQ
//