ID   A0A182PJI1_9DIPT        Unreviewed;       632 AA.
AC   A0A182PJI1;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   24-JAN-2024, entry version 32.
DE   RecName: Full=Cdc23 domain-containing protein {ECO:0000259|Pfam:PF04049};
OS   Anopheles epiroticus.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=199890 {ECO:0000313|EnsemblMetazoa:AEPI007095-PA, ECO:0000313|Proteomes:UP000075885};
RN   [1] {ECO:0000313|Proteomes:UP000075885}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Epiroticus2 {ECO:0000313|Proteomes:UP000075885};
RG   The Broad Institute Genomics Platform;
RA   Neafsey D.E., Howell P., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA   Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Anopheles epiroticus epiroticus2.";
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:AEPI007095-PA}
RP   IDENTIFICATION.
RC   STRAIN=Epiroticus2 {ECO:0000313|EnsemblMetazoa:AEPI007095-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
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DR   AlphaFoldDB; A0A182PJI1; -.
DR   STRING; 199890.A0A182PJI1; -.
DR   EnsemblMetazoa; AEPI007095-RA; AEPI007095-PA; AEPI007095.
DR   VEuPathDB; VectorBase:AEPI007095; -.
DR   OrthoDB; 3131281at2759; -.
DR   Proteomes; UP000075885; Unassembled WGS sequence.
DR   GO; GO:0005680; C:anaphase-promoting complex; IEA:InterPro.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR   InterPro; IPR007192; APC8.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR12558; CELL DIVISION CYCLE 16,23,27; 1.
DR   PANTHER; PTHR12558:SF10; CELL DIVISION CYCLE PROTEIN 23 HOMOLOG; 1.
DR   Pfam; PF04049; ANAPC8; 1.
DR   Pfam; PF13414; TPR_11; 1.
DR   Pfam; PF13176; TPR_7; 1.
DR   Pfam; PF13181; TPR_8; 2.
DR   SMART; SM00028; TPR; 8.
DR   SUPFAM; SSF48452; TPR-like; 2.
DR   PROSITE; PS50005; TPR; 3.
PE   4: Predicted;
KW   Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW   Cell division {ECO:0000256|ARBA:ARBA00022618};
KW   Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW   TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT   DOMAIN          16..235
FT                   /note="Cdc23"
FT                   /evidence="ECO:0000259|Pfam:PF04049"
FT   REPEAT          310..343
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REPEAT          344..377
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REPEAT          412..445
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REGION          537..574
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          586..632
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        537..558
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        592..610
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   632 AA;  72436 MW;  198A4265107ACB8B CRC64;
     MDTPVDLKAV KQDIFVGIVQ CEMRCLMQCT KWLAELNHGL SDTPLELRGN TAFEDAHSGI
     DESEYDNYLL AKSYFNVREY DRSAYFTRNC TSPVPKFLHL YATYMSKEKK RLDNMTDSSV
     VSSVSHAKDF AELLSILRTE HSQQLLDGYC LYLYGVILKK LDLTDIAVRV FVEAINAKPT
     LWSAWLELAP LVSDKRMLES LELPNHWMKS IFEGYAYIEL FQNDEGIKIF ENLQKNGFGK
     CIFIPTLLAI AYSNKRDVDR SIDIFQHLQS IDPYRLDNLD SYSNLLFVKD MKTEMSHLAH
     KVVEINKYSP ETCCVVGNYY SIRSDHYKAV MYFQRALKLN PRYLSAWTLM GHEFMEMKNT
     NAAIQSYRQA VEVNKRDFRA WYGLGQAYEI LKMTFYSLYY YKAAQQLRPY DSRMLVALGE
     TYEKLNKVAD ALKCYQKAYN VGDIEGVALY SMAKLYEKQG ETDKAIPAFL KFCSDEKLIA
     DKASLCHAYM TLGNYYEKIE DLDKASYFAY KCLDYEELKR EAESLLKSIA NKRASKPTTS
     VAPSAAAATA TTSASGEAPA QGEKPPTAET YGEDMEMDET YLSKRIGMEV TGEEEVEEDV
     EEDEEERVDS SELAESATVP EFHMEDTYDV NE
//