ID A0A182PJM1_9DIPT Unreviewed; 2248 AA.
AC A0A182PJM1;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 08-NOV-2023, entry version 30.
DE RecName: Full=Rap-GAP domain-containing protein {ECO:0000259|PROSITE:PS50085};
OS Anopheles epiroticus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=199890 {ECO:0000313|EnsemblMetazoa:AEPI007135-PA, ECO:0000313|Proteomes:UP000075885};
RN [1] {ECO:0000313|Proteomes:UP000075885}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Epiroticus2 {ECO:0000313|Proteomes:UP000075885};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Howell P., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles epiroticus epiroticus2.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AEPI007135-PA}
RP IDENTIFICATION.
RC STRAIN=Epiroticus2 {ECO:0000313|EnsemblMetazoa:AEPI007135-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR STRING; 199890.A0A182PJM1; -.
DR EnsemblMetazoa; AEPI007135-RA; AEPI007135-PA; AEPI007135.
DR VEuPathDB; VectorBase:AEPI007135; -.
DR OrthoDB; 20915at2759; -.
DR Proteomes; UP000075885; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0033596; C:TSC1-TSC2 complex; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0032007; P:negative regulation of TOR signaling; IEA:InterPro.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR035974; Rap/Ran-GAP_sf.
DR InterPro; IPR000331; Rap/Ran_GAP_dom.
DR InterPro; IPR003913; Tuberin.
DR InterPro; IPR018515; Tuberin-type_domain.
DR InterPro; IPR027107; Tuberin/Ral-act_asu.
DR InterPro; IPR024584; Tuberin_N.
DR PANTHER; PTHR10063; TUBERIN; 1.
DR PANTHER; PTHR10063:SF0; TUBERIN; 1.
DR Pfam; PF11864; DUF3384; 1.
DR Pfam; PF02145; Rap_GAP; 1.
DR Pfam; PF03542; Tuberin; 1.
DR PRINTS; PR01431; TUBERIN.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR PROSITE; PS50085; RAPGAP; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468}.
FT DOMAIN 1977..2203
FT /note="Rap-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50085"
FT REGION 660..679
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 939..1005
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1112..1309
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1470..1675
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1723..1780
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1863..1882
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2198..2234
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 660..674
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 943..968
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 969..1005
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1121..1176
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1196..1245
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1260..1299
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1470..1504
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1505..1540
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1561..1575
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1578..1593
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1594..1626
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1628..1644
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1660..1675
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1748..1767
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1863..1877
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2204..2234
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2248 AA; 245955 MW; 606062A6603EB6DE CRC64;
MAGRERETQL SRFKQFFRIT KPGSVSSTRH DLPISPELER ELRPETPVTQ RCKALRDFGE
QVLTSRLEPD AVQSLWELTK DLLVGNKLTE QRQCALAFYC RLIQGQYDRL GMMRAQFYRV
IESHSEPEDI SFRLEMLKLL TETGKNIQHF EKEIGPFLLE WIKPIHEAGY IDSLLELIVN
LIKYNAACLE PKFLVGVVSY IFDMTCNKQE TNTILLCLSV LDCFICYAII PNESLTLFII
ILCRMVNQEA YCQHSWKIMK NLFGTALGHA TLLTMCNILN NPAFHQDDAL LRGAIFHTNV
GLWGISVVPI LHCSPSLVLT SFWNALKSRH VIVTYEVILS MNRLIQKSGN ELNEPTWDII
CDIMTEISHN LAIHRLPADH TLVTHFHETL NMVETLLQQG TLNADPEKVY GLIEHVSAER
PEASVRQLID YRASKISATR SEWLKQLCQF MDRFYRMKNS NVRIYAVQAL ERIMAANRAA
YEDEILERIV IVHLGTVPLE KDPEVRKAVA RTLIEFTIHC ETKRCIELLE IVEKLLHRPY
DENQVVRSEQ EAEDIILLVD GLIRLFIVKL YRLPSLHAIR VYSMLIGLLE LHYQRPHVLA
NVTSVRYRIF SWMMKARANG SFHIGYPDPD DGNRVRFSHY LGIEGPYQHQ SLQPQPYLSS
QSTSQLNLTG TGGSEAGSKA MDRIPATNLT TISIKRGCQV IVLCLKEEKD WEVIQLVLTE
LPSVMQNKAL IQGNDVDSLA RTLYRMYTDK MQLEKLQVPA NMVPKMSDYM ELILPALSSL
AMYHQHLDFN TQKNIIDALK QGLISRRPHE CIRMLTILLL EMPEQLMPKM ADLLLELSKM
TGTKMVALPV LEFLSTLILV PSFRFGNFTM RTYMCVMAMS LPFTNPFRYD HYTVSLAHYV
VAAWFIKCKL PMRHQLVKFI VQGLESYVHV PFQDGSRSFS QVNEDSSERK RSSSLTEQSS
RRRDRIQQQA QQQKQSQQQQ QAGSKATGAG VSSSNASGST ASIAQSSAQL PSQKVYSISP
LNDDMYRFHC ELADTCVDFM VRHTFSPCSG ISKRLPSAEF LLSGGQSMTW LVGHDLITIT
TSGCSGVTFR NGLCDRCHQY CQSAATAANG SGDPGSAKLI APYQQHQQQQ QHHHHALLSK
SNSSASTATT TTTVGGGAQP LSPEPPFSSA SSGKDSGLSG IGLGVDGGVS AAGNNGLPMT
PASATTSNKR YTKASLQHSS ANESDSTDLT TSSSTSSSTA ATPFPTAPHS AHGPVSGGGL
SATGGTNATA GNRFFRQGSQ EGYSSGSLEA LSRRGSNPDS VDPTMAPGVM GSVGSELQLQ
RTNSLVAPRA PPGLIATIGN RLILPQQLSS SMTGASSSSS GIGFDKPVQP CACVCTGWAE
VAVRRPTGFT SWITRIQSQV SHDILGGDVS LQDLTSLFSP SVGGGVIGSD YLTLGAGTDG
MTPFGSSADI PSATLVDRII APGHHAFVSE SELQPSNPGS SELINPVPAP TTASTGTQHN
RAKVSISDEV FEMAKKGEAK KKPSVEEEHE QSEDEELRNV LAGGVEGAPS LSGGGSGPIN
IPGKQPNTSA IASDDDGDGS HSDDDDDDDE EGTDENARKI KYDGNDEVMF DDTDGRTRKP
VRRVNSSPEM RTKWNSQFLS KAKESVGQQD PAAIVSATGG DPATTVTTTS GVLGQSGTEA
STVVEKKKST YGKGVSCEAI PEEIAGSTPP PPTALRMQSN VNEAQSNAGA PPAPPPTVRG
TATAKHQAEF GATKSTPITT SLPESNTLEP MVAPRKQHSA DDATLATRSL IDGSGATSNE
AINLQGSVVP NVSGAMIAPI AMHPITQTSS SSALSLKLPM EKVTSKPPQS PVPLSPRLIA
RNTSNLKQSS SGTASPSFPA MGGGMGSGIG GGLLLGMGGG NDNDNLPRGR SKTISTVREH
YSRDGSKWSA ANVSRMRNEH INRTVVSPSF VFLQLYHHGQ FGNECPLLMD KDPEKAIALL
DLIPPFEMHK IGVLYVGPGQ AGNETEILKN RYGSLRYAEF LSSLGTLVAI KDAKEKNIFI
DLESNGKDGA FTYIYQDDIV QLTFHVATLM PNKRQDPHCN EKKKHIGNDF VTIVYNESGE
EYDLKTIRGQ YNYACVIVEP IELNSNRVFI RSKDDIAQHV TRDTKIVSDH TAPLLARQMA
LHANLASLVA QSLKTKNSSP YASNWLERLR KIKNIRSRYG QQHDDQQKQQ QQQQLQQGGG
SANDLSSAAS SSNSGISYRV DDFSKYTV
//
