ID   A0A182PKP6_9DIPT        Unreviewed;       597 AA.
AC   A0A182PKP6;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   RecName: Full=Serpin domain-containing protein {ECO:0000259|SMART:SM00093};
OS   Anopheles epiroticus.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=199890 {ECO:0000313|EnsemblMetazoa:AEPI007513-PA, ECO:0000313|Proteomes:UP000075885};
RN   [1] {ECO:0000313|Proteomes:UP000075885}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Epiroticus2 {ECO:0000313|Proteomes:UP000075885};
RG   The Broad Institute Genomics Platform;
RA   Neafsey D.E., Howell P., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA   Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Anopheles epiroticus epiroticus2.";
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:AEPI007513-PA}
RP   IDENTIFICATION.
RC   STRAIN=Epiroticus2 {ECO:0000313|EnsemblMetazoa:AEPI007513-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the serpin family.
CC       {ECO:0000256|RuleBase:RU000411}.
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DR   AlphaFoldDB; A0A182PKP6; -.
DR   STRING; 199890.A0A182PKP6; -.
DR   EnsemblMetazoa; AEPI007513-RA; AEPI007513-PA; AEPI007513.
DR   VEuPathDB; VectorBase:AEPI007513; -.
DR   OrthoDB; 3231833at2759; -.
DR   Proteomes; UP000075885; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.30.39.10; Alpha-1-antitrypsin, domain 1; 1.
DR   Gene3D; 3.30.497.10; Antithrombin, subunit I, domain 2; 2.
DR   InterPro; IPR023796; Serpin_dom.
DR   InterPro; IPR000215; Serpin_fam.
DR   InterPro; IPR036186; Serpin_sf.
DR   InterPro; IPR042178; Serpin_sf_1.
DR   InterPro; IPR042185; Serpin_sf_2.
DR   PANTHER; PTHR11461; SERINE PROTEASE INHIBITOR, SERPIN; 1.
DR   PANTHER; PTHR11461:SF130; SERPIN 85F; 1.
DR   Pfam; PF00079; Serpin; 2.
DR   SMART; SM00093; SERPIN; 1.
DR   SUPFAM; SSF56574; Serpins; 1.
PE   3: Inferred from homology;
KW   Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW   Serine protease inhibitor {ECO:0000256|ARBA:ARBA00022900};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           30..597
FT                   /note="Serpin domain-containing protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5008131449"
FT   DOMAIN          81..591
FT                   /note="Serpin"
FT                   /evidence="ECO:0000259|SMART:SM00093"
FT   REGION          208..337
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        208..274
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        275..292
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        306..329
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   597 AA;  66913 MW;  B8442BFE63C415B6 CRC64;
     MRTGLKCVLL RVIILHSVVC VLRVGTVNGQ FYSLSFGTDE SYEPPPAQAP VPPSGPAHQH
     AIHQKVTPLE AMIDKTNHLG FRVLHQHSKG NRNNIAFSPC ALASILVALY EGAAGNSAAE
     LHEQLVVPYD KDVLRVGYRD IHRRLRSYFY QKENLLNGLS LSSENITIRP EYESVLKFYG
     YDLESIPEMR MPTTTTPLPT TTLELETDEA TSDATTEMGN ATDTLEPSTT SASAPDETTA
     ESTVEVTSTE ASATTVDTTE VEPTTNVPSE PAEDTTTDTT EETSEPSTVE GDESATEETG
     GEKRRRNLRK RGQRLLQRRH PNSPQRRRSV RTKRQPEEID IISHQRFLQN FLLQDVTTGS
     PAPPTLLATA GFPAPAIDNA VRKNPFLQQP DAYRLLDDTI EHNFYLTEAD IVKVPYKVYN
     TILKYAYIER LQSTVIELEL DSDDYKLLII LPDYEFGLGN VLKLLQIGDN VPSLREVTEH
     MSPTWVKTIV PKFNLKGNII LTSDLQNLGM NDIFEPSRAD FSLMTEDPTI YAKHIEQSIN
     VNIRTHSLQQ LKRFTSLYKN PVELAVNYPF LFCILDNELD LALVVGRILN PLNARIH
//