ID   A0A182PLJ1_9DIPT        Unreviewed;       602 AA.
AC   A0A182PLJ1;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=Ionotropic glutamate receptor C-terminal domain-containing protein {ECO:0000259|Pfam:PF00060};
OS   Anopheles epiroticus.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=199890 {ECO:0000313|EnsemblMetazoa:AEPI007811-PA, ECO:0000313|Proteomes:UP000075885};
RN   [1] {ECO:0000313|Proteomes:UP000075885}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Epiroticus2 {ECO:0000313|Proteomes:UP000075885};
RG   The Broad Institute Genomics Platform;
RA   Neafsey D.E., Howell P., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA   Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Anopheles epiroticus epiroticus2.";
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:AEPI007811-PA}
RP   IDENTIFICATION.
RC   STRAIN=Epiroticus2 {ECO:0000313|EnsemblMetazoa:AEPI007811-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC       family. {ECO:0000256|ARBA:ARBA00008685}.
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DR   AlphaFoldDB; A0A182PLJ1; -.
DR   STRING; 199890.A0A182PLJ1; -.
DR   EnsemblMetazoa; AEPI007811-RA; AEPI007811-PA; AEPI007811.
DR   VEuPathDB; VectorBase:AEPI007811; -.
DR   OrthoDB; 3133575at2759; -.
DR   Proteomes; UP000075885; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015276; F:ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR   GO; GO:0050906; P:detection of stimulus involved in sensory perception; IEA:UniProt.
DR   Gene3D; 1.10.287.70; -; 1.
DR   Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 1.
DR   InterPro; IPR001320; Iontro_rcpt_C.
DR   PANTHER; PTHR42643; IONOTROPIC RECEPTOR 20A-RELATED; 1.
DR   PANTHER; PTHR42643:SF35; IONOTROPIC RECEPTOR 41A-RELATED; 1.
DR   Pfam; PF00060; Lig_chan; 1.
DR   SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        284..309
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        365..383
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        561..581
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          289..572
FT                   /note="Ionotropic glutamate receptor C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00060"
SQ   SEQUENCE   602 AA;  68603 MW;  BA342747A15676A0 CRC64;
     MDMAITQLRT DISAIPTMSV LMRFLIMKYY SQHYSFCTVG KDFLRDVLPG RILLSVDDQL
     ATNLLRAVDN GCQAFIVDEL GIENFLDLFI PVHDLAYQRS LDKRLILMLT QQNQTHLFER
     IRSHGALREL PNVLFVVYDE QERPTNLYHS VVGIFDVLDP TVNVVMEKIP IDWERSWKHH
     AFFPEKSSNL QGYVLRMATL NYLPFTGYER LVEDEDEWGE VYPNGTGNGL MGSVAERQTD
     IAFGAFYLWY KPYNFSTYTA TISRSGVTVL VPKPKMLPFW HTPFLSFSLQ LWIMVMVTFV
     TGIFATWTAG KVRLRLLLMT SPANRTWTEP SDLFAEQLTL SDAVLMMVGF FVAQSSSIRN
     DLWSCVFLFT SLLLAGFMVS NLYSGGLASV MTVPKYEKSI DTVIDFADSE MKLLGPTSYC
     LEEIWNASEP HLVQIQKTFS AAGPQEMNRH AHMGDRGFIV ELAQHGNFAP NNFLDRQCSA
     NLQPLKDFIY TQNCAALITN TNPLRSNLNE YILRVQQSGI LYHLGIRTAN RYLPTDVMQT
     IERSRLHQHD EGAIRLEVGH FLGAFFILGY GLLCAAIVFM GELWGSVFIR RLNETFASRE
     AT
//