ID A0A182PM81_9DIPT Unreviewed; 1116 AA.
AC A0A182PM81;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 08-NOV-2023, entry version 37.
DE RecName: Full=GTPase-activating protein {ECO:0008006|Google:ProtNLM};
OS Anopheles epiroticus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=199890 {ECO:0000313|EnsemblMetazoa:AEPI008054-PA, ECO:0000313|Proteomes:UP000075885};
RN [1] {ECO:0000313|Proteomes:UP000075885}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Epiroticus2 {ECO:0000313|Proteomes:UP000075885};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Howell P., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles epiroticus epiroticus2.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AEPI008054-PA}
RP IDENTIFICATION.
RC STRAIN=Epiroticus2 {ECO:0000313|EnsemblMetazoa:AEPI008054-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR AlphaFoldDB; A0A182PM81; -.
DR STRING; 199890.A0A182PM81; -.
DR EnsemblMetazoa; AEPI008054-RA; AEPI008054-PA; AEPI008054.
DR VEuPathDB; VectorBase:AEPI008054; -.
DR OrthoDB; 24454at2759; -.
DR Proteomes; UP000075885; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd04010; C2B_RasA3; 1.
DR CDD; cd01244; PH_GAP1-like; 1.
DR CDD; cd05128; RasGAP_GAP1_like; 1.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR001562; Znf_Btk_motif.
DR PANTHER; PTHR10194:SF60; GTPASE-ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF00779; BTK; 1.
DR Pfam; PF00168; C2; 2.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00616; RasGAP; 2.
DR SMART; SM00107; BTK; 1.
DR SMART; SM00239; C2; 2.
DR SMART; SM00233; PH; 1.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50004; C2; 2.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
DR PROSITE; PS51113; ZF_BTK; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00432}.
FT DOMAIN 1..117
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 289..438
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 517..711
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT DOMAIN 769..871
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 181..215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1025..1050
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 201..215
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1116 AA; 122817 MW; A891B679CEE21464 CRC64;
MRNEAERVVV VVVACEAKSL VGRSSNGSGT TASSKENRDV YCTIALDQEE ICRTPTIERT
LSPFFGEEYQ FEIPRPFRYL SVYVWDRDRH LKQDKPYGKI AIRREDLNQY NHKDHWFPLR
PVDEDSEVQG MAHLFIYIDD GVGNVKQHSG EFEDYRYLTQ PTTLSRLHQN HFSPLSPHNL
PLQNHHHLHG ASGAGESKEN GGILSYQQPP HSPNPSSNNA LMAVQLNSSV NSTNLKLFYP
TKGSNGNAHT LLGGTVEGKL FDSSHTSPQL LALYTNGAGN GELGHGHGSG GMLSVGGGGG
GGGIGSSVSS QIKIKLTECV DLARKNGLCD PYAIVVAHYS NKKTITKRTK VRKKTINPSF
DETFCFDLCI DACGSDSSKS DSNNMYTVMP LGGADLCEVV ISFKHASPGM GDDVFLGEIR
IPVRGKQQQN AVQSSAWYFL QPRTSQSRPM RTCATPPGTR LSCDNSLGSL RLKLNYTSDH
VFPLATYDQL YNVLTQSINQ KPITASAVHI LGEISHNKTE VAQPLVRLFT HTNLIAPMIK
ALADHEISKL TDPTTIFRGN TLVSKMMDEA MRLSGLHYLH ATLRPIVEEI FAEKKPCEID
PSRVKDVSAI EGNLHNLQDY VGKVFEAITK SAVKCPAILC EIFHNLRECA AKYFPQNKEV
RYSVVSGFIF LRFFAPAILG PKLFDLTTEP VDEQTTRTLT LISKTIQSMG NLVSSRSAQQ
PCKEKYTEQL YKKFCTEQHV EAIKHFLEVI STVGATEAGE GQSSVLEPVV LKEGMMTKRA
QGRKRFGRRN FKQRYFRLTT QSLSYAKAKG KRPICDIPLT DILAVERLNE RSFKMQNIFL
IIKKDQRPLY VQTANCVEEK EWIDLLNKIC QSNKDRLENL HPRAYINNAW TCCNESDKYA
PGCTPKSTSS PIQMDLATAL DPARDLQRLH SLIIANITSL EVLDPALNGT AYEDPMAARI
TIKKLNEIAS TLEQIHRKYK SMLARDLKYG SRQAPIGDDN YLHMPRTGIT AAVMAAAAAA
AATNTSTITT SSTNTTGVNG SSSNNSSSCL SNTGHSGTLG IISGGVSSTG TLGGGSLTPI
TVSTQHYPDA GLAHFFPHRS LLMRSADGGG DPLTQC
//
