ID A0A182PR91_9DIPT Unreviewed; 5491 AA.
AC A0A182PR91;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 03-MAY-2023, entry version 30.
DE RecName: Full=UBR-type domain-containing protein {ECO:0000259|PROSITE:PS51157};
OS Anopheles epiroticus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=199890 {ECO:0000313|EnsemblMetazoa:AEPI009473-PA, ECO:0000313|Proteomes:UP000075885};
RN [1] {ECO:0000313|Proteomes:UP000075885}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Epiroticus2 {ECO:0000313|Proteomes:UP000075885};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Howell P., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles epiroticus epiroticus2.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AEPI009473-PA}
RP IDENTIFICATION.
RC STRAIN=Epiroticus2 {ECO:0000313|EnsemblMetazoa:AEPI009473-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the UBR4 family.
CC {ECO:0000256|ARBA:ARBA00009970}.
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DR STRING; 199890.A0A182PR91; -.
DR EnsemblMetazoa; AEPI009473-RA; AEPI009473-PA; AEPI009473.
DR VEuPathDB; VectorBase:AEPI009473; -.
DR OrthoDB; 10597at2759; -.
DR Proteomes; UP000075885; Unassembled WGS sequence.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd19680; UBR-box_UBR4; 1.
DR InterPro; IPR025704; E3_Ub_ligase_UBR4_C.
DR InterPro; IPR045841; E3_UBR4_N.
DR InterPro; IPR045189; UBR4-like.
DR InterPro; IPR047509; UBR4-like_UBR-box.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR003126; Znf_UBR.
DR PANTHER; PTHR21725; E3 UBIQUITIN-PROTEIN LIGASE UBR4; 1.
DR PANTHER; PTHR21725:SF1; E3 UBIQUITIN-PROTEIN LIGASE UBR4; 1.
DR Pfam; PF13764; E3_UbLigase_R4; 1.
DR Pfam; PF19423; E3_UBR4_N; 3.
DR Pfam; PF02207; zf-UBR; 1.
DR SMART; SM00396; ZnF_UBR1; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS51157; ZF_UBR; 1.
PE 3: Inferred from homology;
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 1796..1865
FT /note="UBR-type"
FT /evidence="ECO:0000259|PROSITE:PS51157"
FT ZN_FING 1796..1865
FT /note="UBR-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00508"
FT REGION 154..185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 345..367
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1143..1200
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1580..1603
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1905..1929
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2423..2453
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2607..2643
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3057..3140
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3319..3350
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4319..4345
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5461..5491
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 3975..4002
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 155..175
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 345..362
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1143..1170
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1177..1200
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1584..1603
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1911..1928
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2435..2452
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2616..2639
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3074..3128
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5467..5491
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 5491 AA; 602788 MW; CDD61961CC9C14CE CRC64;
MAAAHSGGVE WAAILKPFLS SSSENISKTD VLNLVKTIIL NENEILEHDA AHKQFFDNFV
VLAAENITNQ VTSLSQTQLP QFTEAASILI RYIILHLDTT APCKPSILLM ALKLLCEGKR
ANENQPHSTS SASSIISVSG MKYLKYPEIP GNKSASVGAP SSGTSAGSSA SASDKESPKT
EMKRSRSDLS TVILQQLTTP LCSWAVTFAA LSEEQIDCTD LFVKQNLQCM NAINAGDSLL
KWCTTALGTP AKYRFKYEES TMLGRPLYLP VTHTEANAIK NIFNLMESDI TNLQLAISLP
LLEPLTPKKI TLLSQCAMSA LYCCVLTSTA VSVITMASAG SQKTSSSGQL QQAQGQTGIT
QAQKENEEEE DFARAIVDKG LEIFTKIGNL LKTSTRTHIY QNLICMGAWL LISGIQGTMG
ASGNASGLQQ MVPVSAKTSE ESLKGRSPLK TLDVPQMASA QPSPALRVNL FKVQQGFGVL
NAAIARHSII LMTELIDDLK IDSRTDEEEY SSIESAGFDI LGQYTSIQRV VRVLNSATLQ
QLLTFLATVS YRKACTLRRI NTKNTNDGEP MSYSDSTTYF NDTFSCSEES EPEEEDSDSY
LGLWFKETLS PDMNEEMTES QEQENKDEKS RLGTNLVPAK DEPHEYLSLA SLIFNFFDVS
LGGNHVYLNR YVKTGLSEQQ MVLLANILRD LDRDSARGET DIPGCMQWQN AMVKFSGAVG
RYLHNLISNS LLNESLQSAL LLHLGVSPWT QDSNVWPLQV YSRTLAVLVQ ILLLKPSQEK
EAACLSVWHR LVNTIVEGIC STQTIPNESE VEDLNVEHAQ LLLFLFHSLN LMQKKSILLL
TAGGVIRCSE VCRSVTPDKP LRDNQIMLLS RLLLFLEYLM KHLYNPPNVL LEQVRWNLFS
VFTLDSEQKL ADLVNYKTKM MSFCRKDIED KHRKLANEFS VSGVKPKFYS LTTVESKVQQ
EFKLDGLAWN FILCTPDKLK YPWLIDALID ILGITDMCLA RIPFQTLCAV HYCFSLSWKL
LLGLPPSTQH VEALMQEKSP NLHSLLWSIR CLHPITHSHY LIVNSLVKQG MYTQSAEAMW
VRLTEYVSDV KYSLKMTLLG LESFVKSFSP DQPRLSKIIL LDSLMSHLFA VCWAEKEGVN
VKTSKTTATS ATSSTASGTS SSSTANAGPA AAPNDGNLVG ANTTTMSGGG VPGSSTLADG
SPSAITVEIS RADLTKNIMH ALLDALEIVR EATYKTMFQN LSGQIPTCLI EPLIAIAGTK
NSFCSELGQQ LVNCITGHDK DVITVEWRKS LGSLTEENFA SGSFPVETHT LTVIEAHLTE
VSKHLSYSIL LSLKNALKSA INLIYYMLPN YDDIKLDERL KEILIPMVFD LRAEYLHGPI
NKCLESLLGG DSNCEAYQLA AFSNIIRHSY QFLIEYTDLC ATGRATNIDE SVLCNILKYW
ESMLEKPNGL RSMRSFFYES KSGNLVQILL SFTGTNISQA YSTRVLQFFE KLFQAAEKLD
ASFDEEELCV CIAELAVTDS ARLKSWLSHI LLGPGGISLT ANASNNSSNV PTPTNMATVS
AIPSITDQLA ASGTAAGAGA NGEAGLSENN TTAANAATTT EGEQQDAMDI DYECMTKGSG
WQAAATSCGK MAIEDASGES LERNGKLLQS LVKYIVAENR ISSSVSEALF QALIQIGHNL
LSPTQEAIEF SDLLQVMITL ADAAIDWLDV CRVQVLDAGK NGSSGWRAAI QLDNVTAILK
YMSDLLLGLG AKGSKTMNPP WDEESLMDAD DILEELGADE EDSTVEDSDE DSLGNKLCTF
SITQKDFMNQ HWYYCHTCKM VDGVGVCSVC ARVCHKNHDI SYAKYGNFFC DCGAKEDGSC
QALSRRSNSG NGEDSILGST SSASLLPRSN DAESLLLASS LLRRRHPSSP AHEGPSTSRA
SQGKLSEREQ QLAKIIETSR EALNNPSQWK TVIRCILVFF NSLMPTIKEH CARYSPVGCY
WRAKSALEKL HRPEKTYVLS DEIMIATLGS QEGAFENVRM NYSGEQGQTI KQLLSTYLVR
RVALCCLASP HGKRQQLAIS HEKGKVTILQ LSALLKQADA AKRKLTLTRL ASAPVPCTVL
SLASNPANED FLAVCGLKEC HILTFTSTGT ANDHIVLTPQ LDTGNFIKRA IWLPSSQTKI
ALVTADFVKI YDLAEDSYSP QYYFLVPSGK IRDCTFVYDQ EGTYFMLIMS SLGYIYTQPL
SDESLAKHGP FYVTSTLELD HPLITDDNGQ ILAGGVSIYY SHVLQMLFFS YAAGRNFMAP
LTNVNEGVKC VINLVCNPSS KLLSKSTTQP LCQWTEIPGH PGLVCAMMQS LNNPVIFMIK
PDGYMAQEIK AQNAKAKIMD MVAIRHSVSG VEKTTLILLC EDGSLRIYAA HPENTGYWLS
PEVQPIGHQH GFGWYGSNGS TYGKSTRKSK KMGKQSSHGG NASSSATGKG GTGSAPSFPI
DFFEHCTLMN EVEYGGNDLL QIYNTQHLKH RLNSTGLYVT STKANGFTLE VSNNDPNMVI
TGVRVQIGSQ DVSKAPQRVT ILGRSVTTVA TRARWFDIPL TREESLQSDK KLNIHFGPSI
DAEQITILDS IKIYGKTKDV FGWPEETEDA TGGPMANGAS GNNGQTAMAN GNASNDGANG
DDNDAGGMYM TSLDRMLSSM LQVLDSGISL LGGSNCDDNY RQTAIDVATN LVLFPTVNVV
QQDARNVLMT CHPNKAAYHS YKDKEILNDI YRQLKQMYEA TESGDIDPEA FYRAVLMMRS
IAIQRPQAMA KICAEQQMDI LALMMILMKE LYRITPAYEE PIAIVKRGLC HTEAVIYSLV
EIIYAFALAD SEQVEKMTKL FVRLLLDPAP IISHSAKVAM IRLLRPKIKR RKVVLIESPP
VCSTPTPSGA TAAAVAGPSS SSLSVGSSTS GADPSTSAGS VAVANEDFAA VAAAAAAAGG
MQEVDAIESL GLEPSAGNQA IASLEALLGV GFPHLLEAPE TDDDTIMEIA IALSLQDNEA
DLQLLQQSIA NYQGRNRNPA AQSLAAAIAG GSSFNVESNT SGGGSDDDEI SNVATEGSTL
RTSPAGEHAG SGSGGSESGC SGVESIGGTS GRSSTYEEQP NPSPPRTSVV DQMPSQSAGS
SATPSQPRVA EVEPTDASGE SANKLHMLRC SILNQLVENF SAMDTVNGAQ CIPFMQVILM
LTSDLDGTQE ADQHALSFLL QALIDRLEIR STKVYQMANR TPKTEVQLVV LRLIGVLMGK
VKSKSSSSSS SAGASGAAAQ SSDRSGVSQA MLDNATFLAQ TTANALMKSN AIPYCLMIME
SFLPHWKNAS TSSIDDLASP ATGASTTNAP ASSSSGSTSN ATSNNAGPVI TAPGGNASNV
LLKPTLYGAF PDMQPFFARP FPKGSNDVFE MYSHVLTEMA VRLPYQILKL SSGHPSSQEW
NHSLCEYMTA TLCEYMMYMQ SPVLRRQVRK LLLYICGSKE KYRQLRDLHS LETHMKAVKK
CCEAGCSQAS PSPSLTNSHS TILSYDALVE LTEHFRACQE IASIRTGNWQ KFCVRNADIL
SSLLNISTYQ LEDGVSMIIL QLLQSAICNT SPQVQQVKSS LSTVTVDQQM KVSVVVKDRK
DRDKSEESDM MAAPSESKFD AAQCVALVAQ IFNQVSAASL SKFIRSFLLE TNSTSIRWQA
HSLVYAFYEN SSDPHKETLL QCLWGLWPLL PAYGKRTAQF VDLLGYLTLN TRSLIDKLPD
YTAQAVSVLR QQNELLSKHP NAPIYTALGQ VLELEGFYLE SEPCLVCNNP EIPFSNIKLS
TIKVDSKFTT TTTIVKLVQS HTISKIALRI ADLKRAKMVR TINIYYNNRT VQAVVELKNR
PLMWHKARKV TLQSGQTDVK IDFSLPITAC NLMIEYADFY ETVSGSSESL QCPRCSAVVP
ANPGVCGNCG ENVFQCHKCR AINYDEKDPF LCHSCGFCKY AKFDYSIYGR ACCAVDPIES
AEDRAKTVQT IHTSLEKADR SYKSLQNNKQ ILELLVQKVS EHKLDRALDE TLVGASVIGG
AGGTSQVNKV IQLLAQKYCV ESKTTFEELS KIIQKVQACR KELVAYDRSQ MDAPPSATPM
STSFASSAGT SSSRTSAVAL NKCYGCALAS TEQCLTLLRA MASNMACRVG LCSQGLVQEL
AINNLRRGTH QLQDEVRHLL CLLTRDLPDA TEALCQLLQD RVKMALSGTV PLATLDSAVR
HEMALLEAMT SQDDSCWETK LRTVIELFLQ ASRDARGPAT AVIHPCLRIV QSLMCPPPIL
TNTFPTGSKQ HSKEPTVNSL QDLCTVQPIE GITVSYEKWI AGDANHSFAA WKARMPPVSS
ANTGATNRRT TGESSALSMA SAAAPSQPIG SGFRSALEHR RATLRNAYLV EKYAKRWRQK
ALAKGILSIP VELQAAWLQP ILFNTNSRLG RQLACALITS LSRTNERKRE LLDLLTSFLR
YVGESGEASA EFLALYRMLA DETPWRQYLA LKGVLTLLVQ LVTEEIEKIH CLEETTLSTD
LAQGYALRQL VELMALFLEN PQIRKAYKGK LLGPVLQGYL DLRKLIVQRT RLIDDAQEKL
LEMLEEMTTG TEEETAAFMA VCIDTVRRTP TSDVKTPVFM FERLCSIIHP EENDVGEFFL
TLEKDPQQED YLQGRMLGNP YPSHEAGLGP LMRDVKNKIC IDCELVALLD DDNGMELLVH
NKIISLDLPV KEVYKKIWLQ EGGERDSMRI VYRMRGLLGD ATEEFIETLN AKSQEEVDNE
QLYRMANVLA DCGGLKVMLE RIGSLQNVSK SRTLLQVLLK LFLLSVKVSR CQEVLCQPEL
GAINTLLKVL QLCLQSSESD TQQSAVTEQL LEIMETILSK AASDTLDSFL QFSLTFGGPE
YVQALLSCTN CSNVRCNPSV LRHLIRVLAA LVYGNDIKMA LLCEHFRSVF NFDRFDAERS
AEEEFKMELF CVLTTGIEHN SIGGTLKDYI MSLGIVEKAL GYIKSHAPCV KPTLLRTDSD
ELKEFISRAS LKYILRFLTG LATKHEATQL AVAQDIIPII HRLEQVSSDE HVGSLAENLL
EALCTEPATA KRVQEVRDFT RAEKKRLAMA TREKQLDALG MRTNEKGQVT AKGSILSQIE
KLREETGLAC FICREGYACQ PNKVLGIYTF TKRANVEEFE MKQKKTIGYT TVTHFNVVHV
DCHMNAIRLA RSRDEWESAS LQNANTRCNG LLPLWGPDVS ESSFSSSMAR HNNYMQECTQ
RCEITFASSM HDLKLLLWRF AQEKSFHEDA GGGGPQSNMH LVAYLLFYGL YTLLSSRSYS
REEMILSGFI GHKTSERWLE CAYEAEGPLY LLTMSLALHT PDLWSRHKLI HLQRLIAIAQ
ARHVSPNSVC KFLAPLDKHP KDYTIYKPYL MFWGLVDLIY RNFFRTVATP KDEDWPISLF
NYIRRNDESL LKTADSTLQT FTEEYLPCAS FAEFCDVAGL LGDIENPDGW MEELLQALPA
PGGSSAAGSS AAGSSSGTGS GSAAGGSSNT E
//
