ID A0A182PRH7_9DIPT Unreviewed; 1097 AA.
AC A0A182PRH7;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Interference hedgehog {ECO:0000256|ARBA:ARBA00041099};
OS Anopheles epiroticus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=199890 {ECO:0000313|EnsemblMetazoa:AEPI009561-PA, ECO:0000313|Proteomes:UP000075885};
RN [1] {ECO:0000313|Proteomes:UP000075885}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Epiroticus2 {ECO:0000313|Proteomes:UP000075885};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Howell P., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles epiroticus epiroticus2.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AEPI009561-PA}
RP IDENTIFICATION.
RC STRAIN=Epiroticus2 {ECO:0000313|EnsemblMetazoa:AEPI009561-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- FUNCTION: Mediates response to the active Hedgehog (Hh) protein signal
CC in embryos, functioning upstream or at the level of patched (ptc).
CC {ECO:0000256|ARBA:ARBA00037573}.
CC -!- SUBUNIT: Homodimer. Heterotetramer; 2 iHog chains bind 2 hh chains when
CC facilitated by heparin, heparin is required to promote high-affinity
CC interactions between hh and iHog. {ECO:0000256|ARBA:ARBA00038530}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily. IHOG family.
CC {ECO:0000256|ARBA:ARBA00038144}.
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DR AlphaFoldDB; A0A182PRH7; -.
DR STRING; 199890.A0A182PRH7; -.
DR EnsemblMetazoa; AEPI009561-RA; AEPI009561-PA; AEPI009561.
DR VEuPathDB; VectorBase:AEPI009561; -.
DR OrthoDB; 3138076at2759; -.
DR Proteomes; UP000075885; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008201; F:heparin binding; IEA:UniProtKB-KW.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProt.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd00063; FN3; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 5.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR PANTHER; PTHR44170:SF53; BROTHER OF IHOG, ISOFORM G-RELATED; 1.
DR PANTHER; PTHR44170; PROTEIN SIDEKICK; 1.
DR Pfam; PF00041; fn3; 2.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF13927; Ig_3; 2.
DR SMART; SM00060; FN3; 2.
DR SMART; SM00409; IG; 4.
DR SMART; SM00408; IGc2; 3.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 4.
DR PROSITE; PS50853; FN3; 2.
DR PROSITE; PS50835; IG_LIKE; 3.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00022974};
KW Heparin-binding {ECO:0000256|ARBA:ARBA00022674};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Proteoglycan {ECO:0000256|ARBA:ARBA00022974};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 46..64
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 807..829
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 244..336
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 345..417
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 434..518
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 572..674
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 686..780
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 70..123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 527..560
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 851..880
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 899..923
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 960..1024
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 17..34
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 95..123
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 906..923
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 967..982
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 996..1016
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1097 AA; 120599 MW; CC0C02C73137E763 CRC64;
MYGEADKRPR TQPPFVSDRR SLLSRTQQHL PHCCGGSSRT ERRIPYGGLL LLCLVLTMCI
FPPVSSSPQS SYSHHSHHSH GHHHQAAPHG VLSGTGSHHS GSGSATASQQ YGSSSGRSSS
SGSGLGVYII RAPESTIAPA DDEVLFECEL NLVPEQLDWR FRAQGTSGQR KDYVLIQSNH
HGYNASVVDG RYKLRVSVSE STIGEYQCVA WFGASAIASI PARLTLATIG LEAESIPGRH
DRVPTTMRRI QPLQHFKVFP GNSIIIDCGD IVSNPPPIWS YYRDGMTIYP NVTQLQTGRR
LILASLTQRD SGTYWCSAVN SITGSEVLLP QRTTVTVDYV PRSAPRAFTQ PQNVSVLPGD
TALLECPGVG NPVPVPAWTR ANGIPLNARA RIQDYGLQLS NVHPEDEGQY LCRLQNGIDP
PLLHSIWLTV LEPPRIVAPP RSTLTNESDS LELECIARGS PHPDIYWMIN GDYTKWDSLI
RTNGTRLIIQ SVEKRHAGIV QCFARNSVGE ASEGNLLQVI PKQIPGGVGT TPLGSVPSSP
KSGNDHSPKR KGGKKHKNRK YGMRIPNMVM IPPSRPNITR LSDESVMVRW SVPSSDGLPI
QFFKVQYRML GDPSKNIART QWMTENDDIS PYTRSYEVNN LKPDHLYRFR IVAVYSNNDN
KEGAASGKFH LQRGSQLGLT KNHLLAPTLT RIEPVSQHAV VLQWQFPQHL PHPIDGFYAY
YRPATTAGEY SKATVDSSTA RHFKIDHLEP GTAYEFKLQS FTASAASDFS EILTGRTLKP
PTPPPTVPTV IAAAEGPDGS QVVPVNYLLV IGCVLIVSVL IVLFLCCCFS RRKKRGHGAD
EPDAKVHIPV DQNGFTGAVS NGGPRVAHHK TRTNGMNGRM NITPNPLAQD GDKVTASFHA
SCGIPQPQKP HQQQQQQQQQ QEQLMLASMP HRRTLERTAV RPIPNGATIA YGVDPKLMLD
SGQPAVSPPD CRQSSMRRTR RGSGSVPGSP RIGRGPSNEF LQQQQQQQQQ QGVTVARSPM
PMRAAGMKRS AATRLGRAEN MSSGSLNSIE LMYLVRRRMR KPRAAAATPS ALPQQDSEHH
CHKQAFYERA NGYRLIS
//
