ID A0A182PRW5_9DIPT Unreviewed; 1941 AA.
AC A0A182PRW5;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EnsemblMetazoa:AEPI009700-PA};
OS Anopheles epiroticus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=199890 {ECO:0000313|EnsemblMetazoa:AEPI009700-PA, ECO:0000313|Proteomes:UP000075885};
RN [1] {ECO:0000313|Proteomes:UP000075885}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Epiroticus2 {ECO:0000313|Proteomes:UP000075885};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Howell P., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles epiroticus epiroticus2.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AEPI009700-PA}
RP IDENTIFICATION.
RC STRAIN=Epiroticus2 {ECO:0000313|EnsemblMetazoa:AEPI009700-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR STRING; 199890.A0A182PRW5; -.
DR EnsemblMetazoa; AEPI009700-RA; AEPI009700-PA; AEPI009700.
DR VEuPathDB; VectorBase:AEPI009700; -.
DR OrthoDB; 5474185at2759; -.
DR Proteomes; UP000075885; Unassembled WGS sequence.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:UniProtKB-EC.
DR CDD; cd00051; EFh; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 3.
DR Gene3D; 3.30.2230.10; DUSP-like; 1.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR InterPro; IPR035927; DUSP-like_sf.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR006615; Pept_C19_DUSP.
DR InterPro; IPR001394; Peptidase_C19_UCH.
DR InterPro; IPR018200; USP_CS.
DR InterPro; IPR028889; USP_dom.
DR PANTHER; PTHR21646; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR PANTHER; PTHR21646:SF76; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 32; 1.
DR Pfam; PF06337; DUSP; 1.
DR Pfam; PF00443; UCH; 2.
DR PRINTS; PR00450; RECOVERIN.
DR SMART; SM00695; DUSP; 1.
DR SMART; SM00054; EFh; 2.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF143791; DUSP-like; 1.
DR SUPFAM; SSF47473; EF-hand; 2.
DR PROSITE; PS51283; DUSP; 1.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
DR PROSITE; PS00972; USP_1; 1.
DR PROSITE; PS50235; USP_3; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837}.
FT DOMAIN 263..298
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 299..334
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 425..621
FT /note="DUSP"
FT /evidence="ECO:0000259|PROSITE:PS51283"
FT DOMAIN 810..1903
FT /note="USP"
FT /evidence="ECO:0000259|PROSITE:PS50235"
FT REGION 1112..1153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1168..1196
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1234..1264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1489..1522
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1714..1743
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1112..1135
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1180..1196
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1941 AA; 213945 MW; 309BF98A82D6042B CRC64;
MGAKDSKPSC ISYEEAVKRV TDSELRRIKD AFKRSAGTSG SVLSKCAFMQ DVLGDGVPSV
VADWLYTACG GTVKGIAFKE LLCGLVLLTK GTQDEKIKFL WTLYCNESGT HILKQEFQKA
IQIETTYQSN AANSTNNTTN CSNNNNNNQT VANRNNHQQQ LQWSRYQVSL FGQNDRVSFE
QFKSWIQMHR GATALSKWLL QDACVNLSSE LETPTFYQSL AGVTHLEEQD IGDLEKVFWL
LKGAAVTGQL DLESLGPLVS PPVPKAALGG VFLAFDENHD GHIDFKELCC GVSAACRGPS
VERSKFCFKV FDIDRDGVLN FVEIRQMIDI LLSVARESNS GIYRNITHDR VLAELYQRAT
KGGEGSERTC EADGTLLVSA SNVPEFKFTQ EDFLIWSIES SSNLVQPFLD LLFEVCHIVL
GLRPQCRHLE GDIVRGWLSR EVRRGYKVGQ FWYLISSDWW QHWSQYTHLS SSSSSCVHCK
STGTSYANNR AITAVSSLMP NGGTTNGTVD EAMICDESFT SNSTESMGDL LGTGDSSSLG
SGSSGISYGR HASSAPGTID NSCLIAPNIY KQIPTLTGEG GRLKRDLTLV QHRDFELVPD
SLWKALAQWY GGPLPLPRQV IQPHSNGDVE LELYPLNLRI LRHQSQPPPH QQQHGQMAGS
SAWASMSGGY GALTTGSYPT SVSSVPSVLH PPKKYLAYTA AFSRLATVKQ VAEFLCQRLK
LKPEDIRLWH LVPTPTGISE FPYLLEEEQL TLHELSIGDN DQILLEIRNK DLTWPEELGS
LALSQGAAST SMERRGTVAS IQSQHPPGAT GLHNLGNTCF MNAALQVLFN TQPLTQYFIQ
KKHLYELNTT NKMGTKGQLV LRYAELLRDV WTASTRSIAP LKLRFCVTKH APQFSGGGQH
DSQELLDWLL DSLHEDLNRV MEKPYTELKD SDGRSDVIVA AEAWSQHHAR NQSIIVDLFY
GQLKSKVTCQ GCGRDSVRFD PFSLLSLPLP VENYTYCEVL VMLLDGSVPV KYGLRLNSEM
KYWDLKKHLS ELCGLESEQM LICELSNSQI RLILPNEHRI KPSTACELYA YELPKIDSVL
RSRAGSELAI NIEKGLKDIQ RNQDPHQLTT SSINTTISST SSSASSSSTA TTDDLAAITG
RKPGSSTGGG ADGGGALTNG VNYSGGNGGG GGAGGGHGTT MANRRTSATS KHIPEISTSP
DSTFIYGAGQ YSELTGYGGS NGYGNVNSVI NNQQHQSHAS ATQQQPSKDP NRSKTISTTN
LLNNADNGWS NGAGGYDSPN AHHHVHHPYE CNDCDNIYMG EDMPPYGDQQ QQHGDAISLS
AISKRQHATS VLAGQRKTNY LIAVHRKLSR QDTYFLSHHK SKPGLFGVPL LIPCYDGVTN
KELYCSVWLQ VARLLSPLPP TPPDQSNHAT DCDDSLGYDF PFTLRAVGSG GRMCALCPWS
RFCRGCEIPC NDDPLLQGLI CSAPGSASNS STPNLSSREQ TPTLRRKVYA ANSSGSSSLD
GTTTTNHHQL QQPASFTGTS SSPLSSLQSS INTRSIQIAI DWDPTALHLR YQSTRERLWT
VHESVAICRK QQTEPVDLDH CLRAFTSEEK LEQWYHCSHC KQKKPATKKL QIWKLPPILI
VHLKRFNFVN GKWVKSQKVV NFPYEDFDPT PYLASVPQET ILRHRDLLEG VSSGPRGDGR
NRDCHEEFVE FDREMSMIDE ASDEISLSSL RLNGVKEDDD GRDSNDCAGS SNNNNRRSDQ
LDDEARSSII IPAIAGSNHV ASARQLPDSY LLGGSSPSAD GNENTAASTS AVRVKSACSV
RSSDSTRRQR LVSTSLTKTP IIDGELTDFH KHHLKPECDP FELKYQLYAA VCHSGMLNGG
HYISYAANPN GSWYCYNDSS CREIPTRPKI DPSTAYLLFY ERRDLDYEPY LPKVDGRQLP
SEGLLDVDDS DNDLKKMCSL M
//
