ID A0A182PS58_9DIPT Unreviewed; 905 AA.
AC A0A182PS58;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Peptidase M28 domain-containing protein {ECO:0000259|Pfam:PF04389};
OS Anopheles epiroticus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=199890 {ECO:0000313|EnsemblMetazoa:AEPI009793-PA, ECO:0000313|Proteomes:UP000075885};
RN [1] {ECO:0000313|Proteomes:UP000075885}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Epiroticus2 {ECO:0000313|Proteomes:UP000075885};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Howell P., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles epiroticus epiroticus2.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AEPI009793-PA}
RP IDENTIFICATION.
RC STRAIN=Epiroticus2 {ECO:0000313|EnsemblMetazoa:AEPI009793-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the peptidase M28 family.
CC {ECO:0000256|ARBA:ARBA00010918}.
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DR AlphaFoldDB; A0A182PS58; -.
DR STRING; 199890.A0A182PS58; -.
DR EnsemblMetazoa; AEPI009793-RA; AEPI009793-PA; AEPI009793.
DR VEuPathDB; VectorBase:AEPI009793; -.
DR OrthoDB; 277019at2759; -.
DR Proteomes; UP000075885; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008235; F:metalloexopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd03875; M28_Fxna_like; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR048024; Fxna-like_M28_dom.
DR InterPro; IPR045175; M28_fam.
DR InterPro; IPR007484; Peptidase_M28.
DR PANTHER; PTHR12147:SF26; ENDOPLASMIC RETICULUM METALLOPEPTIDASE 1; 1.
DR PANTHER; PTHR12147; METALLOPEPTIDASE M28 FAMILY MEMBER; 1.
DR Pfam; PF04389; Peptidase_M28; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00023049};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 383..410
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 431..453
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 465..487
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 508..528
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 534..556
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 563..584
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 604..628
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 640..658
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 158..354
FT /note="Peptidase M28"
FT /evidence="ECO:0000259|Pfam:PF04389"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 905 AA; 100449 MW; 839D8A983C6FC717 CRC64;
MAGGTTSSGR SKVKAKGVDD SHRANAPVED TTNLHQLEAQ HGILGIVLLL FCGTVSSYLC
TYLPEALTRA DLDRHPTAFI AERAWDNLQV LNDFGPKPTG SQANELKAAD YIRREIEKAK
VTAHAAQLVE TSHQTISGAY PIAFLGNPLT SVYRNVQNLV VRLAGQKNAD GSGDALMLNC
HYDTVASSPG ASDDGGSCAV MLEILRVLSR APERNRHSIV FLFNGAEETP LQAAHGFVSQ
HPWAGEVRAF LNLESAGSGG KEQLFQAGPQ HPWLIEAYGR AVRHPAAQTV AEEIFQSGII
PSDTDFRIFR DFGHMPGMDF AHTINGYRYH TKFDTIDYLS LPVLQRTGDN ILALTREIAN
GDELGRASND TQLTSGYSVF FDVLGLFFVS YSAAMGRIVN VTIAVLSLII PLMELCRQVR
RVGERSVFQQ ALVGLLGTVC GTGTSVGVVL VIANRLDAVG RAMSWYSTPY LILGLYGCPV
ILMHCFAHRL CGHWFSDNKS PLNLTQIVRA RLVGVNLFWT LLIIPLTLAN IRSAYIILVL
LVLSLLSTIL TSVLGYQRLP RRWLALHLAF QIPAMLWATK FYHVLLKLFV PITGRMGAGS
NPEYLIALLV ACFGVLCVSY LVPLVGLLKQ TSELTARLSV FAMIAFLLSC CTQVGFPYRN
ESNGEPSLQR HYVTHTLQVA QRDGRPVLEG AGFLFREMDR NAIRVIRGIA KPSEAVQMRR
MASCRTMLFC GVPFYSIWHQ IRFDNYWMEG SPPAIEKHTL PSFELVQVKQ HSNKIRQYGF
EITHRHQTCV QSALIIAPKS GARLVAWSLM ETVPGTIEFN GEWAHFVLIT YGLADNAPWP
VTFDFEYDPN VVPDGSDDKL FDVSWVNTYW EYADKHTDEF RKLIEQFPDW AHVIPSVAIV
NITAY
//