ID A0A182PT67_9DIPT Unreviewed; 1323 AA.
AC A0A182PT67;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=Ionotropic glutamate receptor C-terminal domain-containing protein {ECO:0000259|Pfam:PF00060};
OS Anopheles epiroticus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=199890 {ECO:0000313|EnsemblMetazoa:AEPI010153-PA, ECO:0000313|Proteomes:UP000075885};
RN [1] {ECO:0000313|Proteomes:UP000075885}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Epiroticus2 {ECO:0000313|Proteomes:UP000075885};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Howell P., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles epiroticus epiroticus2.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AEPI010153-PA}
RP IDENTIFICATION.
RC STRAIN=Epiroticus2 {ECO:0000313|EnsemblMetazoa:AEPI010153-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Membrane
CC {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC family. {ECO:0000256|ARBA:ARBA00008685}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 31 family.
CC {ECO:0000256|ARBA:ARBA00008661}.
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DR STRING; 199890.A0A182PT67; -.
DR EnsemblMetazoa; AEPI010153-RA; AEPI010153-PA; AEPI010153.
DR VEuPathDB; VectorBase:AEPI010153; -.
DR OrthoDB; 3108846at2759; -.
DR Proteomes; UP000075885; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0016758; F:hexosyltransferase activity; IEA:InterPro.
DR GO; GO:0015276; F:ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR GO; GO:0050906; P:detection of stimulus involved in sensory perception; IEA:UniProt.
DR GO; GO:0006486; P:protein glycosylation; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.90.550.50; -; 1.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 1.
DR InterPro; IPR002659; Glyco_trans_31.
DR InterPro; IPR001508; Iono_Glu_rcpt_met.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR PANTHER; PTHR42643; IONOTROPIC RECEPTOR 20A-RELATED; 1.
DR PANTHER; PTHR42643:SF13; IONOTROPIC RECEPTOR 20A-RELATED; 1.
DR Pfam; PF01762; Galactosyl_T; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR PRINTS; PR00177; NMDARECEPTOR.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..27
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1013..1039
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1067..1084
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1096..1116
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1285..1305
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1023..1292
FT /note="Ionotropic glutamate receptor C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00060"
FT REGION 119..187
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 123..145
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 160..183
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1323 AA; 150268 MW; 8C39A02029EB01A3 CRC64;
MPCPGLKVSH VIFVIVILIT IVFYSSLNGR HFILEPRRYA NHRKNDPSPL ANRTLAGSTV
ADKGLLVAGG APPGPVAAAS SSTAERQKCN VFQIVVQGCG FNMLTKTLER AQQQQQQLDR
NQTQLQKEKE KEQQEQQEQE TAPEHVDNIQ RIPNPSAVVK AVPGSSSSSS SSSSSSSSLP
PAPQPTALEA EGEKVIKTRD LYHSGHLPDA ACVSNLCPQN GTDVTLLILV TSAPTHREQR
LAIRQSWGHY GSRRDISIGF IVGQTDDARI EDQLAAESYM YSDLIRGNFI DSYRNLTLKT
ISLLEWTKLH CPNASFLLKT DDDMFINVPK LLQFMEAHGN QRRTIFGRLA KKWKPIRNKK
SKYYVSPEQY YPPVFPPFTT GPAYLLTADI ISEMFEKSLS QTYLKLEDVY TTGIVAQLLN
IHRLNVKEFL NRRIAFNQCN IKKAISIHMV KNNEQLDLWK KQVDTSVWLF FGGSLWKSTV
AHPPIILDRE YLGADYEKTL DETKNIVEKM IREHLKNGGL IVKYYSWTSI NLKRDFSAVL
SVSSCKNTWD IYQEAVRERL VMLSITDPDC PRLPTNNAIM IPRSDGSGNA FDEVSQIILD
MKSSRAIGWH TATLLYDQAY DAEISRCILS LLEDREGIKP LTLTEFKINA PTHSWEKRKE
IRRTLLGIPT AYTGRNFIAI VNMATLTLLM EISKDLKLVN PFSQWLYLIP NTEKASGDFT
TQSTIINEGD NVAFVYNSGS KAHNCTVLVE RVSVLCYMES YLLHFIRSLS KLIREEQVVF
GQISDEEWEI IRPSKQERKA KFLQMIKAAI TSKDECNKCS QWKIQSAETW GYMYRTDFLP
DANDAQERKK YSILDIGYWS PQDGFMLTDA LFPHSQYGFR GVQLIFYSYH NPPWQFVSYN
ESGNPVITSG VVYDILTELS RKLNFTYTMV ISQPAEINGS LVEGNSSFVY DLKTISSDIP
QEILTTLVNN KILLAAIGST VNEKQKKFVS FTDPISIQTY SFIISRPREL SRVLLFLSPF
GSDTWLCLAA AVALMGPILC AINKLSPYYE VHNKPTDIGL GKVNNCFWYI YGALLQQGGL
YLPYADSGRI IIGTWWLVVL VIVTTYCGNL VAFLTFPKID IPVNRVMQLL RNDRGMTWSI
RRGTFLEEFL MDSTEPKYVQ LYKGSQIIGE LTDDLVERIE AGQHVHIDWR NNLRYVMKRQ
FLLTDRCDFA LSTDEFLDEQ IALVMPRDSP YLELVNEEIK RMHQFGFIQR WVSQYLPAKD
KCSGTGRVMD VQNHTVNSSD MAGSYWILLL GFLSGLFVFL CEFAVARYRQ HRASKAVTVA
YSN
//
