ID A0A182PV99_9DIPT Unreviewed; 1000 AA.
AC A0A182PV99;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=SH3 domain-containing protein {ECO:0000259|PROSITE:PS50002};
OS Anopheles epiroticus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=199890 {ECO:0000313|EnsemblMetazoa:AEPI010886-PA, ECO:0000313|Proteomes:UP000075885};
RN [1] {ECO:0000313|Proteomes:UP000075885}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Epiroticus2 {ECO:0000313|Proteomes:UP000075885};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Howell P., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles epiroticus epiroticus2.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AEPI010886-PA}
RP IDENTIFICATION.
RC STRAIN=Epiroticus2 {ECO:0000313|EnsemblMetazoa:AEPI010886-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; A0A182PV99; -.
DR STRING; 199890.A0A182PV99; -.
DR EnsemblMetazoa; AEPI010886-RA; AEPI010886-PA; AEPI010886.
DR VEuPathDB; VectorBase:AEPI010886; -.
DR OrthoDB; 5476196at2759; -.
DR Proteomes; UP000075885; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0002039; F:p53 binding; IEA:InterPro.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR047163; ASPP1/2.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR24131:SF10; ANKYRIN-REPEAT, SH3-DOMAIN, AND PROLINE-RICH-REGION CONTAINING PROTEIN, ISOFORM B; 1.
DR PANTHER; PTHR24131; APOPTOSIS-STIMULATING OF P53 PROTEIN; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00248; ANK; 2.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 2.
DR PROSITE; PS50088; ANK_REPEAT; 2.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT REPEAT 829..861
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 862..887
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 928..991
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 206..242
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 268..289
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 414..460
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 523..623
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 685..750
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 427..460
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 523..546
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 562..604
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 685..702
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 703..730
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1000 AA; 110279 MW; B254094958417AD2 CRC64;
MAMRQQHQID TQHQMLAAKE QRLRFLKSQE TRNAVSIAEA ERLRRLRERV EAQESKLRRL
RALRGQVDLQ KTYNVTLGND LDSIRALFSE KEKELTLAVA KVEALTRQLE ELRRDRRGVG
NGANGISYNV NSNALNYNSS PVAKELEKLR LELAYRNQLS MQQNARLNMQ RETLQQRQIE
LHSVDKRIIE LQSRINKKRI LNVQNYKFNG GNNSPASGHN NHSKTLQPNA NHPLHSRSSS
THIIPTHSRT LSRGNIVAVE PFNHVPVKSS SSGDGLNLTL SPSSTGNIND KTLQMTSSTS
DFMQQQHPQQ APSMIQNYQW DHDAASKMMG GEEAMLLAPE SDEKKLAVRQ QQQQQQYRSR
FVESNDNVLE TETENGLETK DVQLNMVSND FEMKNNSNSP SSYDNANGMF DFYEKNTHDN
DFESDSATSL DKGQSNGNNI GANSIGNSSQ DKHHQSIPSQ PKASYNFLQN IPLGNLVVPP
RKPINSVAPT LAMKPSSTNA ANSGSVNELG AKITSVTRKV PVGIENTGTT NEADQTTAST
SPNNNIRPAL PPKPNKSSGF GNVGAIVPTT SGNHNSNDEY GNETTVGLSA GGTSNENESS
SAPFDMPDLS LPGSNNKQSA ANDKLPIKAK PLTIRKHPFL EQPKLKNFTS SFNPNQNAYT
GMNKFSNASA TQQITNKRKE AAAVETANSE TNDATQYSNY EGESLNDKKH ASDNSEFHVG
REHPIERLKK LKSGNTNSTD GNGNSEHEIT RRKRNFISMT PDGQGNASGN GIGSGNGVTM
VGEGSKHKLS RRVSFDPLAL LLDASLEGEL ELVEKTAMQV TNPSAANDEG ITALHNAICA
GHFEIVKFLV NFGCDVNAQD SDGWTPLHCA ASCNNLPMVK FLVESGACLF AATLSDHETP
AEKCEEDEEG FDGCSEYLYS IQEKLGILNN GEVHAVFSYE SQQPDELSFF VNDKLTIIRK
GDESEREWWW ARNSLGNEGY VPRNLLGLHP RLTPSYSDEN
//
