ID A0A182PVY6_9DIPT Unreviewed; 936 AA.
AC A0A182PVY6;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EnsemblMetazoa:AEPI011123-PA};
OS Anopheles epiroticus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=199890 {ECO:0000313|EnsemblMetazoa:AEPI011123-PA, ECO:0000313|Proteomes:UP000075885};
RN [1] {ECO:0000313|Proteomes:UP000075885}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Epiroticus2 {ECO:0000313|Proteomes:UP000075885};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Howell P., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles epiroticus epiroticus2.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AEPI011123-PA}
RP IDENTIFICATION.
RC STRAIN=Epiroticus2 {ECO:0000313|EnsemblMetazoa:AEPI011123-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR AlphaFoldDB; A0A182PVY6; -.
DR STRING; 199890.A0A182PVY6; -.
DR EnsemblMetazoa; AEPI011123-RA; AEPI011123-PA; AEPI011123.
DR VEuPathDB; VectorBase:AEPI011123; -.
DR OrthoDB; 5360131at2759; -.
DR Proteomes; UP000075885; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProt.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR GO; GO:0030522; P:intracellular receptor signaling pathway; IEA:UniProt.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:UniProt.
DR GO; GO:0048511; P:rhythmic process; IEA:UniProtKB-KW.
DR GO; GO:0006805; P:xenobiotic metabolic process; IEA:InterPro.
DR CDD; cd19730; bHLH-PAS_spineless_like; 1.
DR CDD; cd00130; PAS; 2.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR039091; AHR/AHRR.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR InterPro; IPR013655; PAS_fold_3.
DR NCBIfam; TIGR00229; sensory_box; 1.
DR PANTHER; PTHR10649; ARYL HYDROCARBON RECEPTOR; 1.
DR PANTHER; PTHR10649:SF12; SPINELESS, ISOFORM C; 1.
DR Pfam; PF00989; PAS; 1.
DR Pfam; PF08447; PAS_3; 1.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00086; PAC; 1.
DR SMART; SM00091; PAS; 2.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS50112; PAS; 1.
PE 4: Predicted;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Biological rhythms {ECO:0000256|ARBA:ARBA00023108};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 6..59
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 105..160
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT REGION 561..738
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 798..848
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 860..936
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 561..582
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 610..625
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 654..686
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 709..724
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 798..823
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 863..929
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 936 AA; 102880 MW; 0D7B6E6415E7C847 CRC64;
IKTTPKEGIT KSNPSKRHRE RLNAELDLLA SLLPFEQNIL SKLDRLSILR LSVSYLRIKS
YFQVVMHKEK GENGLVPHSV SEESYRARDY TSYDHSFIVD SDMFLQALNG FIMILTCEGE
VFFATHTIES YLGFHQSDII HQSVYELVHS EDREELQKQL LWNSFLPADL SGIQLSEALV
PEKDKLLERS FTVRFRCLLD NTSGFLRLDI RGRVKILHGQ NKKNEEPPLA LFAFCTPFGP
PSLLEIPPKE NMFKSKHKLD FSLVSMDHKG KNTLGYSDSE LANMGGYDLV HFDDLAYVAS
AHQELLKTGA SGMIAYRYQK KDGAWQWLQT SSRLVYKNSK PDFVICTHRQ LMEEEGRDLL
GKRTMDFKVS YLDAGISSTY FESDQLIVNS NNSSAPSSPT TSQQRANRRY KTQLRDFLST
CRHKRKLPNQ CAAEQVSPSV SVVDYIPGGP PGTAAAAAAV AAAAYSNSIN SVYSPAAHFP
GSAPDNVYMT GPVHSSNFYP MPDNLFHQYR LQGVSGYYPE YHTSTSASTF VPTNGLIPYD
SYGITKEDTM RWHEGTKSYG AAGELSQSHP ASAESSQQPD APGGCATGEG TYLVSIFASA
PGTDPRSPHV SKGSCHQTGK SVSPHSSEEL VDPCCTVDGN ATPTKDSLDR HTHHGSQTHH
RPHSTQHHHP GTHHNAHHHH QHHHAVQQHH QDIQQLHPHV HPHSHPSHHH RNGDGPEEHK
MDSAKSPAAS SSPIRHNEPQ RQTVLMWGTS YSNSSISGNG DPHASSSNGS PSYDYIDSTG
NFNLVALPKP VSVGSSISSN ELNNTGSSIN SNSTTNLSTN ANPHQTPPVP PTGDATLEPP
IDGVSRGIAK PIPSHIALNK AKQLQPIDSS SGSNSYSGKQ QSKTFANHSA NQPPVTPQTA
PSQQHQTDAL PDGTMGSTNN MNNASADTKW YCTDDA
//
