ID A0A182PVZ7_9DIPT Unreviewed; 1139 AA.
AC A0A182PVZ7;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE RecName: Full=Breakpoint cluster region protein {ECO:0008006|Google:ProtNLM};
OS Anopheles epiroticus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=199890 {ECO:0000313|EnsemblMetazoa:AEPI011134-PA, ECO:0000313|Proteomes:UP000075885};
RN [1] {ECO:0000313|Proteomes:UP000075885}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Epiroticus2 {ECO:0000313|Proteomes:UP000075885};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Howell P., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles epiroticus epiroticus2.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AEPI011134-PA}
RP IDENTIFICATION.
RC STRAIN=Epiroticus2 {ECO:0000313|EnsemblMetazoa:AEPI011134-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, axon
CC {ECO:0000256|ARBA:ARBA00004489}. Cell projection, dendritic spine
CC {ECO:0000256|ARBA:ARBA00004552}. Synapse
CC {ECO:0000256|ARBA:ARBA00034103}.
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DR AlphaFoldDB; A0A182PVZ7; -.
DR STRING; 199890.A0A182PVZ7; -.
DR EnsemblMetazoa; AEPI011134-RA; AEPI011134-PA; AEPI011134.
DR VEuPathDB; VectorBase:AEPI011134; -.
DR OrthoDB; 2916231at2759; -.
DR Proteomes; UP000075885; Unassembled WGS sequence.
DR GO; GO:0030424; C:axon; IEA:UniProtKB-SubCell.
DR GO; GO:0043197; C:dendritic spine; IEA:UniProtKB-SubCell.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd13368; PH_BCR_arthropod; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR037769; Abr/Bcr.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR23182; BREAKPOINT CLUSTER REGION PROTEIN BCR; 1.
DR PANTHER; PTHR23182:SF1; RHO GTPASE ACTIVATING PROTEIN AT 1A, ISOFORM E; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF19057; PH_19; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Synapse {ECO:0000256|ARBA:ARBA00023018}.
FT DOMAIN 386..583
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 598..758
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 787..905
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 936..1135
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 1..206
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 281..309
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 322..343
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..63
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 99..117
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 133..170
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1139 AA; 125695 MW; C91E283BB269AE97 CRC64;
MSIFSPPPKY VRRAAPVEPP TVPTMAMQNL RNKDPAQTAS TPENTPATGM TPDSPSSCSL
ERNIKPSEIY RQKSSDSLDV KLSGYGAEHP GKALLPKSDS LKSKSSSTES PTGSLGKVVS
GGTPGIGASP TGSLGKLPTN MTGSSSDSPT GSLGKMNQHQ QHQAPPYSNP YHQRHGTDGG
LPHVDSKESL ASIGGGTGTI GSTGAVGPIS ERIKSYESIS SLSSDSMRVS SQQNQKDQEH
YYDTVPLDNS DGDYVYIQPG GVGTGSTSSR DDISTVENAS TLLMPSHPRS HNSSQTSVQL
EPESPGRSSN YVNIEYFIHS SQNNENRSSS IDSDGEGDGG APVLMRAIST DTDAGSGAGQ
GISPGVGTPS GSGLFRKISN ANRDMIIRRI VTSIITSETL YVECLNKMKQ YMKAIRATLT
TSQPVISEEE FQTIFFKIED LHEVHSEFLT ELQARLAAPD EPSPGTGEGG GLCVGEPFRR
LAAQIHLYGA FLHNYGRAID TVKMCSTHSQ QFKEIVSNIV FKNQNEQKLS LEELLHKPVA
RVQKNALVLE DLLNQTPEQH PDYHALRQAS KAIRNFLSEF NVVQTRSMFP SDDKALRRLV
KNSFIVELAD GHRKLRHLLL FNDVIACAKY KAVGRAGDRN GFEFELKWFI PLRDILICEE
SANDPKETSP INIVHLKSQA CTVRDQIMLD EKDRPGGSSR AGDKHRKKLA DLEAQLVLAS
PNLVFKIGNK ATGKTMTFFL SSDFERTQWI ESILSLQQSC NLPGHIPVQI YDLHAWITAC
QALIKNEMGS YLMRNARDES LLVGDLHLTI QGLSGFDQPC DLFVCVEIDS YGHYFRKAKT
KLVCRSATPN WNESFVLELE GSQNLRILLY QDDVQRPILR AKHILKLSRS WMQETPTRKV
LQLSETLSIS TIIRFVPGEV TLRRVPTSKP GALFGAKLQQ VIKREKRDIP FIVSACVREV
ERRGMTEVGI YRVSGSASDV AKLKKSFETN AYEAEQLLKE VDIHSVTGIL KSYLRDLPEA
LFTDQYYPKL FDAFNRHSNL SEASRIHELQ RIFAELPQPN KATISLLLDH LMRVHQQEIE
NKMSLHNLAM VFGPTLLRPG PSATKQKDLL ESSTADVMTQ AGILYSFLQA RLKMINMVA
//
