ID A0A182PZM0_9DIPT Unreviewed; 765 AA.
AC A0A182PZM0;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Tyrosine-protein kinase Wsck {ECO:0008006|Google:ProtNLM};
OS Anopheles farauti.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=69004 {ECO:0000313|EnsemblMetazoa:AFAF000146-PA, ECO:0000313|Proteomes:UP000075886};
RN [1] {ECO:0000313|Proteomes:UP000075886}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FAR1 {ECO:0000313|Proteomes:UP000075886};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles farauti FAR1 (V2).";
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AFAF000146-PA}
RP IDENTIFICATION.
RC STRAIN=FAR1 {ECO:0000313|EnsemblMetazoa:AFAF000146-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR EMBL; AXCN02000558; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A182PZM0; -.
DR STRING; 69004.A0A182PZM0; -.
DR EnsemblMetazoa; AFAF000146-RA; AFAF000146-PA; AFAF000146.
DR VEuPathDB; VectorBase:AFAF000146; -.
DR OrthoDB; 3717396at2759; -.
DR Proteomes; UP000075886; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProt.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0002009; P:morphogenesis of an epithelium; IEA:UniProt.
DR GO; GO:0022008; P:neurogenesis; IEA:UniProt.
DR CDD; cd00063; FN3; 1.
DR CDD; cd00192; PTKc; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR002889; WSC_carb-bd.
DR PANTHER; PTHR24418:SF421; INACTIVE TYROSINE-PROTEIN KINASE WSCK-RELATED; 1.
DR PANTHER; PTHR24418; TYROSINE-PROTEIN KINASE; 1.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR Pfam; PF01822; WSC; 1.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00060; FN3; 1.
DR SMART; SM00321; WSC; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS51212; WSC; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..37
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 38..765
FT /note="Tyrosine-protein kinase Wsck"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5008131961"
FT TRANSMEM 381..406
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 40..124
FT /note="WSC"
FT /evidence="ECO:0000259|PROSITE:PS51212"
FT DOMAIN 130..229
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 472..738
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
SQ SEQUENCE 765 AA; 85859 MW; B072E3CA6FB95DA5 CRC64;
MPSTRSAITT ATALCPGWWV VALHGLALLS AVGSVAAAEK RTYFGCYDRD RFARVALTTE
SLDVCVDSCE NNFYRYAVMS GSRCSCTNTI QTRIVEDREC NVTCGKQPDQ NCGGLNAQAI
YETGIDVAGP VRNLRIEGDQ KEDTIAIRWD LPADDGVMVE EFEIIAEVTR TYASFRIYPV
RWSVHNTSTG FELSNLQPGT EYNVTVVSVS GRGAGGRASI VGGTEIGHPD PEPEEPIILR
RFESTILIQI PRATNNNGPV NYYRVVVHYV NSELIQQIDE SQLNTFQQSK VNKVPYYIAA
ELEMKEDDSL LFTVGDGREY RSYFNPPITA RTHVHISIGV VSVLNHVVKV RYATTTHEQH
QYPDHHHVNL KTVEIERNET LITILTVACI LFGVVLTAAI ILYVYLHLKT PNANTRPFGD
HHELTLQGPI LEVENSGFMP DIYEQRGFEA ELRDIIDGLD GTKNHARKYL SLDINRVLGS
GKYGDVLLGA LQRQDCEQPA QVHVITDDME SVDQIAFLNE FRRLTTLDEH ANVILFYGVC
VTPDWCYLLF EQMQTTLKQT LLNARVPPSA NSVKFSTISE EIVVNILCLV CDGMQFLVDN
NVVSKKLCAR TVYVNTKFEV KVSAFGPPLH AEDTGGAIAI ARWHAPEVIK FQNHSTKSDV
WSFGLLIWEC CCLGATPYGT TTTDNLFAAI RAGQKPERPA FMYEDLYQLC LNCWDLDASD
RPTFDDLRRY LRQTLPMLRY LLSFERKQNV QLPPYLPHLE TLGTG
//
