ID   A0A182Q0K3_9DIPT        Unreviewed;       511 AA.
AC   A0A182Q0K3;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   24-JAN-2024, entry version 22.
DE   RecName: Full=Fascin {ECO:0000256|PIRNR:PIRNR005682};
OS   Anopheles farauti.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=69004 {ECO:0000313|EnsemblMetazoa:AFAF000664-PA, ECO:0000313|Proteomes:UP000075886};
RN   [1] {ECO:0000313|Proteomes:UP000075886}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FAR1 {ECO:0000313|Proteomes:UP000075886};
RG   The Broad Institute Genomics Platform;
RA   Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Anopheles farauti FAR1 (V2).";
RL   Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:AFAF000664-PA}
RP   IDENTIFICATION.
RC   STRAIN=FAR1 {ECO:0000313|EnsemblMetazoa:AFAF000664-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000256|ARBA:ARBA00004245, ECO:0000256|PIRNR:PIRNR005682}.
CC   -!- SIMILARITY: Belongs to the fascin family.
CC       {ECO:0000256|ARBA:ARBA00007415, ECO:0000256|PIRNR:PIRNR005682}.
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DR   EMBL; AXCN02002234; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A0A182Q0K3; -.
DR   STRING; 69004.A0A182Q0K3; -.
DR   EnsemblMetazoa; AFAF000664-RA; AFAF000664-PA; AFAF000664.
DR   VEuPathDB; VectorBase:AFAF000664; -.
DR   OrthoDB; 5484756at2759; -.
DR   Proteomes; UP000075886; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR   GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:InterPro.
DR   GO; GO:0007015; P:actin filament organization; IEA:InterPro.
DR   CDD; cd00257; Fascin; 4.
DR   Gene3D; 2.80.10.50; -; 4.
DR   InterPro; IPR008999; Actin-crosslinking.
DR   InterPro; IPR010431; Fascin.
DR   InterPro; IPR022768; Fascin-domain.
DR   InterPro; IPR024703; Fascin_metazoans.
DR   PANTHER; PTHR10551; FASCIN; 1.
DR   PANTHER; PTHR10551:SF9; PROTEIN SINGED; 1.
DR   Pfam; PF06268; Fascin; 4.
DR   PIRSF; PIRSF005682; Fascin; 1.
DR   SUPFAM; SSF50405; Actin-crosslinking proteins; 4.
PE   3: Inferred from homology;
KW   Actin-binding {ECO:0000256|ARBA:ARBA00023203,
KW   ECO:0000256|PIRNR:PIRNR005682};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|PIRNR:PIRNR005682};
KW   Cytoskeleton {ECO:0000256|ARBA:ARBA00023212,
KW   ECO:0000256|PIRNR:PIRNR005682}.
FT   DOMAIN          34..146
FT                   /note="Fascin"
FT                   /evidence="ECO:0000259|Pfam:PF06268"
FT   DOMAIN          155..269
FT                   /note="Fascin"
FT                   /evidence="ECO:0000259|Pfam:PF06268"
FT   DOMAIN          283..391
FT                   /note="Fascin"
FT                   /evidence="ECO:0000259|Pfam:PF06268"
FT   DOMAIN          417..511
FT                   /note="Fascin"
FT                   /evidence="ECO:0000259|Pfam:PF06268"
SQ   SEQUENCE   511 AA;  57398 MW;  07800E92A9E793AC CRC64;
     MNGSGYEINT NGDILLQNQQ KGWWTIGLIN GQYKYMTAET FGYKLNANGA SLKKKQLWTL
     EPSNTGDSII YLKSHLGRYL SVDTFGNVLC ESEERDAGSR FQISITDDNS GRWALKNEQR
     GYFLGGTPEK LTCTAKAPGK SELWSVHLAA RPQVNLRSVG RKRFAHLSDT QDEIHVDANI
     PWGEDTLFTL EFRADEDGRY ALHTCNNKYL NSNGKLENKC TDDCLFSAEY HSGHLALRDR
     HGLYLSPIGS KAVLKSRSQT VTRDELFSLE DSLPQASFIA ALNSKYVSVK QGVDVTANQD
     EIGENETFQL EFDWSAHRWA LRTTQDRYWC LSTGGGIQAT GNRRSADALF ELEWHGDGSV
     SFRANNGKLL ATKRSGHLFA TAEAIEETTK FYFYLINRPI LVLKCEQGFV GYRAPGSNKL
     ECNKAIYETI LVERAQKGIV HFKGQNGKYW RVDGEGIAAD SDVPCDGFFI ELREPTRICL
     RSSDGRYLGA TKNGTFKLVD TGYDTATQWE Y
//