ID   A0A182Q161_9DIPT        Unreviewed;       951 AA.
AC   A0A182Q161;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-JUN-2017, sequence version 2.
DT   27-MAR-2024, entry version 35.
DE   RecName: Full=Serrate RNA effector molecule homolog {ECO:0000256|ARBA:ARBA00017364};
DE   AltName: Full=Arsenite-resistance protein 2 homolog {ECO:0000256|ARBA:ARBA00030701};
OS   Anopheles farauti.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=69004 {ECO:0000313|EnsemblMetazoa:AFAF001020-PA, ECO:0000313|Proteomes:UP000075886};
RN   [1] {ECO:0000313|Proteomes:UP000075886}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FAR1 {ECO:0000313|Proteomes:UP000075886};
RG   The Broad Institute Genomics Platform;
RA   Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Anopheles farauti FAR1 (V2).";
RL   Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:AFAF001020-PA}
RP   IDENTIFICATION.
RC   STRAIN=FAR1 {ECO:0000313|EnsemblMetazoa:AFAF001020-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the ARS2 family.
CC       {ECO:0000256|ARBA:ARBA00005407}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AXCN02002291; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A0A182Q161; -.
DR   STRING; 69004.A0A182Q161; -.
DR   EnsemblMetazoa; AFAF001020-RA; AFAF001020-PA; AFAF001020.
DR   VEuPathDB; VectorBase:AFAF001020; -.
DR   OrthoDB; 4174205at2759; -.
DR   Proteomes; UP000075886; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006397; P:mRNA processing; IEA:InterPro.
DR   CDD; cd00590; RRM_SF; 1.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR039727; SE/Ars2.
DR   InterPro; IPR007042; SERRATE/Ars2_C.
DR   InterPro; IPR021933; SERRATE/Ars2_N.
DR   PANTHER; PTHR13165; ARSENITE-RESISTANCE PROTEIN 2; 1.
DR   PANTHER; PTHR13165:SF0; SERRATE RNA EFFECTOR MOLECULE HOMOLOG; 1.
DR   Pfam; PF04959; ARS2; 1.
DR   Pfam; PF12066; SERRATE_Ars2_N; 1.
DR   SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
PE   3: Inferred from homology;
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242}.
FT   DOMAIN          138..247
FT                   /note="SERRATE/Ars2 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF12066"
FT   DOMAIN          742..922
FT                   /note="SERRATE/Ars2 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF04959"
FT   REGION          261..487
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          852..883
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          912..932
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        280..368
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        382..487
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   951 AA;  106434 MW;  0892BEE5D7DACB1F CRC64;
     MMSTIAKDAT SSAENVAQEA AVEILTVVEL IDQTAQEAET IGRTGGGLVR IIEIIDLLRE
     IEDTLQLEKD LQLNVCVANL GEMKVDIDLE DMTATACMDI PTTISECILQ LGLTVIKQQL
     IKASSGDMQT QPCMMTLKQF LATQDDSISD SDAITKYNEY KLEFRRQQMN EFFVAHKEEE
     WFKIKYHPEE SQKRKEEQLA FLKRRCEVFL ELLNSKEIGK VSVDASNSDA LLRLLDTVVI
     KLEGGTEEDL KILDEKPAVG EPVGRMTAGV PGETGKTETK NESLAVKDVA VKKESDATKQ
     DDQEMRDPVA QDTDESRNGK LNASVDDEQR FDKNSNGENV SKQDIDEAER EDQKSEPGTG
     RKKRSRSDSG SSSSSSSSSS SSDSEEEKES IKKDKEEEES SVKLDEEKNT SSTEPTDDLM
     EKDGNEGKHV DEDSIMEGNE SKDKERSSTD EPMKDKDTSD GPGGDIVDET KSNDGKPQNE
     KDGLEQQKAE TIDLVKDVPA DSGPRALHRT SSIFLRNLAP SITKAEVEAM CRRYNGFLRV
     AIADPLLERR WFRRGWVTFK REVNIKEICW NLNNIRLRDC ELGAIINKDL SRRVRPINGI
     TCHKTVVRSD IKLGAKIAHN LDDKWGLWKE EQNQTSGTAK NGSGDCQPVE SFGLQSKNPV
     LQNITDYLIE EASAEEEELL GLSEDNKKST EGELIERDPQ LIEVLDRLIL YLRIVHSVDF
     YNHCEYPYED EMPNRCGIIH ARGPPSQNKV MNNEIQEYIR TFETKMASFL TRLDDLEDGE
     MKKLGAKDAE VEVEKFITAN TQELAKDKWL CPLSGKKFKG PDFVRKHIFN KHAEKVEEVR
     KEVEYFNNYL KDSKRPQLPE HPGNTKKAGS EGAAPAATAS APGSGYRGQP FGMSHGYAPM
     YAAYAAPPII APNPRGRPGF GRGGRDPAVD PRRPIIAYSD LDAPNFNDSF F
//