ID A0A182Q4E2_9DIPT Unreviewed; 2745 AA.
AC A0A182Q4E2;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 08-NOV-2023, entry version 32.
DE RecName: Full=Ras-GAP domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Anopheles farauti.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=69004 {ECO:0000313|EnsemblMetazoa:AFAF002852-PA, ECO:0000313|Proteomes:UP000075886};
RN [1] {ECO:0000313|Proteomes:UP000075886}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FAR1 {ECO:0000313|Proteomes:UP000075886};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles farauti FAR1 (V2).";
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AFAF002852-PA}
RP IDENTIFICATION.
RC STRAIN=FAR1 {ECO:0000313|EnsemblMetazoa:AFAF002852-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR EMBL; AXCN02000238; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 69004.A0A182Q4E2; -.
DR EnsemblMetazoa; AFAF002852-RA; AFAF002852-PA; AFAF002852.
DR VEuPathDB; VectorBase:AFAF002852; -.
DR OrthoDB; 1356198at2759; -.
DR Proteomes; UP000075886; Unassembled WGS sequence.
DR CDD; cd13313; PH_NF1; 1.
DR CDD; cd05130; RasGAP_Neurofibromin; 1.
DR CDD; cd00170; SEC14; 1.
DR Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR10194:SF142; NEUROFIBROMIN; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00616; RasGAP; 1.
DR SMART; SM00323; RasGAP; 1.
DR SMART; SM00516; SEC14; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF52087; CRAL/TRIO domain; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50191; CRAL_TRIO; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
FT DOMAIN 1266..1461
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT DOMAIN 1597..1755
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000259|PROSITE:PS50191"
FT REGION 2480..2530
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2545..2567
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2711..2745
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2489..2505
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2516..2530
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2723..2745
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2745 AA; 308884 MW; 8B097263D118A7CB CRC64;
LRTFRVKSEN AVKSDTTEHR NYHQMATQKP GEWANSLLAR FEEQLPYRTG PHGTQARLSI
DETMNCLIQI SRYRFSLVIS GLTKMLQRVN EIFQPPACRG HEPERCCYDS LIIILETLER
CLSGQSKDTA RFEEAMNVKL LLREICQFID IQNENNQNAT SLKALASKVL FALSQNHFGA
VFNRISARLQ ELSTCAEENP DYSDIELIQH IDLDVHRLTK LLTETIQKFK SLKKSAHMIL
LSSLEKALWN WIEFHPKEFE DLQRNPNDEL SKCCETFFDI LDSYSENKKA RAAVWPLQIM
LLVLSPKVLE EIVNADSGAP CSPRHLKKKH FMEGIKKGLG AHASSKQSTE SAAIACVKLC
KASTYININD SNNVTFQLVQ SVINDLKALL FNPAKPFSRG QGFNFQDIDL MIDCWVSCFR
IKPHNNEALK VCLSLNSPPA YHFVIVSSLL KIVTQARLPW WPQIDLVYAR SGELRGLFTD
TLNKATQGYI AHTPLRMITS LTLKSKDAQS RLTRPDEGPA HKALLLLMVR LIHADPMLLL
NSLGKAGHEV QSSTLELING LVSLVHQPTM PDVAQEAMEA LLALHSPDKI EVWNPEAPIN
TFWDVSSQVL FSISQKLIQH QIANYTDVLK WLREILICRN TFLQRHKDYA NVGSQIAICR
QAHIKLEVVF FMYLWSVDLD AVMVSLSCFG LLCEEAEIRS GSDELTVGFI LPNYHLYQEL
SHTSATLTSP QNAESRYSFF EHLHGRVTLQ RNIMSLLRKI EHCVNGVQPA WEETFRNWEV
TSKLLQNYPK GKPEEGQAEV FHRSMGKRRA SHQSSEHDLE EQITEWANMT WFLLALGGVC
LQKPRNQRQA TQGYNLPIAT AGPSLMQSTT SLSSSSSGRG SMHPIMGSLV SSIGPGSSQE
VQYCPVTQFI GQLLRLLVCN NEKFGPQIQK HVKELVGQEM SAQLYPILFD QIRSIVEKFF
DQQGQVVVTD INTQFIEHTI YIMKSVLDGR QSKDQNDQPA NAEHLGVTSI ENLMLAIVRY
VRHLDMTVHA IHIKTKLCQL VEVMMKRRDD LAFRQEMKFR NKLVEYLTDW VMGTSHQIAP
PGSGDVTIIT RDLDQACMEA VAALLRGLPL QPEESDRGDL MDAKSALFLK YFTLFMNLLN
DCVDGSEADK DTNNPPLLPP RPRVAAGKLT ALRNATIQAM SNLLSANIDS GLMHSIDLGY
NPDLQTRAAF MEVLTQILQQ GTEFDTLAES VMADRFEQLV QLVTMISDKG ELPIAMALAS
VVTTSQMDEL ARVLVTLFDA KHLLSPLLWN MFYREVEVSD CMQTLFRGNS LGSKIMAFCF
KIYGASYLQG LLEPLIRPLL DEPTSSFEVD PARLEPSEDI EVNRKNLIAL TQKVFDAIVN
SADRFPPQLR SMCHCLYQVL SKRFPNLLQN NIGAVGTVIF LRFINPAIVS PQELGIVGKQ
VPTQIKRGLM LMSKILQNIA NHVEFSKEQH MLCFNDFLRA HFEAGRRFFI QIASDCETVD
QTSHSMSFIS DANVLALHRL LWSHQERIGD YLSSSRDHKA VGRRPFDKMA TLLAYLGPPE
HKPVDSHLLF SSYARWSSID MSSTNFEEIM VKHQMHEKEE FKTLKSMNIF YQAGTSKAGN
PVFYYIARRY KIGETNGDLL IYHVILTLKP FCHSPFEVVI DFTHTCSDNR FRTEFLQKWF
YVLPEVAYEN LYAAYIYNCN SWVREYTKFH DRILAPLKGC RKLIFLDSPA KLNDVIDPEQ
QKLPGATLSL DEDLKVFNNA LKLSHKDTKV AIKVGPTALQ ITSAEKTKVL AHSVLLNDVY
YASEIEEVCL VDDNQFTLSI ANESSQLSFI HNDCDNIVQA IIHIRNRWEL SQPDSVTVHQ
KIRPKDVPGT LLNMALLNLG SSDPNLRTAA YNQLCALTAT FDLKIEGQLL ETQGLCIPSN
NTIFIKSVSE TLATNEPHLT LEFLEECIQG FQRSTIELKH LCLEYMTPWL ANLVRFCKPS
DEGKRQKQVA LILEKLINLT IEQKEMYPSI QAKIWGSIGQ IPELIDMVLD NFIHKSVSSG
LGSPQVEIMA DTAVALASAN VQLVAKKVIG RLCRVMDKTC HSPTQYLEQH MMWDDIAILA
RYLLMLSFNN CLDVARHLPY LFHTVTFLVC TGSLSMRAST HGLVINIIHS LCTCTKPSFS
EETQRVLRLS LDEFSLPKFY LLFGISKVKS AAVTAFRSSC RHPNDRWLGN ERVSQAPPAD
RERLALPSLE VITEALLEIM EACMRDIPDC DWLQTWTSLA KSFAFCFNPA LQPRALIVFG
CISKSITDQD VKQLLRILVK ALESFNDIIL LEALVMCLTR LQPLLRPESP IHRALFWVAV
SVLQLDESTL YAAGLALLEQ NLHTLNSQQL FDNQNIADVM MATREPLEWH FKQLDHAVGL
SFKSNFHFAL VGHLLKGFRH PTPTTVSRTS RVLTMLLGII AKPHRRDKFE VTPDSVAYLT
ALVCFSEEVR SRCHVKHTVP RWPVESGGSG DSGSGSSSDP SAPNSAGGGP LSGGSGPAGS
SASGGHSVRR QKSWDMLDQS AIQYARQSHK VQQHQERGSR SSVSNESNVL LDPEVLPDSS
TQALVLTVLA TLVKYTTDEA ETRVLYQYLA EGSIVFPKVF PVIHSLLDQK VNNVLSVSND
QIVLASVQSI IQNMLASEDA SQQPLHFLQS CGFGGLWRFA GPFTKYNMMV ESSELFVNFL
EAMVETCLPV EESTPMPPSP RPYNLSSSLS SLTLGSPTDK GSSSN
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