ID   A0A182Q4T1_9DIPT        Unreviewed;      1240 AA.
AC   A0A182Q4T1;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   13-SEP-2023, entry version 33.
DE   RecName: Full=RH1 domain-containing protein {ECO:0008006|Google:ProtNLM};
OS   Anopheles farauti.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=69004 {ECO:0000313|EnsemblMetazoa:AFAF003078-PA, ECO:0000313|Proteomes:UP000075886};
RN   [1] {ECO:0000313|Proteomes:UP000075886}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FAR1 {ECO:0000313|Proteomes:UP000075886};
RG   The Broad Institute Genomics Platform;
RA   Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Anopheles farauti FAR1 (V2).";
RL   Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:AFAF003078-PA}
RP   IDENTIFICATION.
RC   STRAIN=FAR1 {ECO:0000313|EnsemblMetazoa:AFAF003078-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
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DR   EMBL; AXCN02000959; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A0A182Q4T1; -.
DR   STRING; 69004.A0A182Q4T1; -.
DR   EnsemblMetazoa; AFAF003078-RA; AFAF003078-PA; AFAF003078.
DR   VEuPathDB; VectorBase:AFAF003078; -.
DR   OrthoDB; 3685563at2759; -.
DR   Proteomes; UP000075886; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005078; F:MAP-kinase scaffold activity; IEA:InterPro.
DR   Gene3D; 1.20.58.1770; -; 1.
DR   Gene3D; 1.20.5.1000; arf6 gtpase in complex with a specific effector, jip4; 1.
DR   InterPro; IPR039911; JIP3/JIP4.
DR   InterPro; IPR032486; JIP_LZII.
DR   InterPro; IPR019143; JNK/Rab-associated_protein-1_N.
DR   InterPro; IPR034743; RH1.
DR   InterPro; IPR034744; RH2.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR13886:SF4; JNK-INTERACTING PROTEIN 3; 1.
DR   PANTHER; PTHR13886; JNK/SAPK-ASSOCIATED PROTEIN; 1.
DR   Pfam; PF16471; JIP_LZII; 1.
DR   Pfam; PF09744; Jnk-SapK_ap_N; 1.
DR   Pfam; PF19056; WD40_2; 1.
DR   SUPFAM; SSF161256; RILP dimerisation region; 1.
DR   SUPFAM; SSF50978; WD40 repeat-like; 1.
DR   PROSITE; PS51776; RH1; 1.
DR   PROSITE; PS51777; RH2; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490}.
FT   DOMAIN          10..98
FT                   /note="RH1"
FT                   /evidence="ECO:0000259|PROSITE:PS51776"
FT   DOMAIN          437..507
FT                   /note="RH2"
FT                   /evidence="ECO:0000259|PROSITE:PS51777"
FT   REGION          277..305
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          844..867
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          71..165
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          367..465
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   1240 AA;  135746 MW;  FFAA8074E165D8E7 CRC64;
     MESNTGEPSE VVYGTHEDSA MVMSEKVQSL AGSIYQEFER MIQRYDEDVV KTLMPLLVNV
     LECLDSAYQT NQEQDVELEL LREDNEQLVT QYEREKNARK QAEQKLLETE DLAEQENKEL
     ASRLESLESI VRMLELKHKN SMDHASRLEE RESELKKEYS KLHDRYTELF KTHVDYMERT
     KLMMGNSTHS QAGSASERLD VSRSRLMPMM RSTGPVSYGF ASLENSTMLD TETLCSEEDS
     GPDSGPPSLQ NEIDTKATEK LEEVDAATTL PADAMATSSN AKVLQSPTAG GGVSGKTTTK
     KEQRSANTLY QELSFQDDNL ESEENEITGA WVHPGDYASS GMGKEVENLI MENNELLATK
     NALNIVKDDL IVKVDELTGE IEILREELNA VILARNKLKA KVTELEEELK KTKAQVKQAS
     SSATDQEEEG DVPMAQRKRF TRVEMARVLM ERNQYKERFM ELQDAVRWTE MMRASRVENL
     DKKSKQGIWK FFSNLFSSND RPTNESPGRL HQRYGGVGAQ SQAHHTASLL PAMPEGRMLI
     GAGGSGSGSG GVGIAGAVGG LGAGSSSALM RAGGHASNIL VLSKEPELTQ SERAMQRRRD
     QYRQVRAHVQ KEDGRLQAYG WSLPSLKPSN ANGGIGGVGG SGGSGGRTSG SGVPVPVPVY
     CRPLAEASPH MKVWCASGVN LQGGYTKDGG CIVGAASIFY AKDTTSVGGA QITELTGEEA
     TTEPKDLGEL LERKILALGA PNSLDADSEL SSYVWICTST HSASTVTVID AKNPSEVLDS
     FPVCQNHLLC ICTVRGALEM DYAMLENSEV TKSGKMLEKP GESPDDIGKV SYERVVRSVA
     ETEAAVPADE HKVTEQAQEV VPPADSGLEQ ATEVNNDRDL NHNSKICNVP IENVGVESKN
     VAIAVDGNDN TIGETVASSP SRQQQQSAAI EESISSIGPT MWLGAQNGML YVHSSVARWN
     VCLHKIKLPD SVLSIVHVES RVIVALANGT LAVFRRQVNG EWDLNSYHLL TLGSPKYSVR
     CLTIVGDKVW AAHRNKIHVI DPITLCILKS FEAHPRKESQ IRQMATTGLG VWVSIRLDST
     LRLFSAETYD HLEDIDIDPY VSKMLGTGKL GFSFVRITAL LVSCNRLWIG TGNGVVISVP
     LTDASGASNT PYSPRFANAQ LSFHGHRDAV KFFVSVPMNP PNHGLPTTSK DMLVISGGEG
     YIDFRLGDGD MEASVELEPN QTIENRNEKS YIIVWKVSNR
//