ID A0A182Q5M1_9DIPT Unreviewed; 749 AA.
AC A0A182Q5M1;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 08-NOV-2023, entry version 31.
DE RecName: Full=Transglutaminase-like domain-containing protein {ECO:0000259|SMART:SM00460};
OS Anopheles farauti.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=69004 {ECO:0000313|EnsemblMetazoa:AFAF003526-PA, ECO:0000313|Proteomes:UP000075886};
RN [1] {ECO:0000313|Proteomes:UP000075886}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FAR1 {ECO:0000313|Proteomes:UP000075886};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles farauti FAR1 (V2).";
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AFAF003526-PA}
RP IDENTIFICATION.
RC STRAIN=FAR1 {ECO:0000313|EnsemblMetazoa:AFAF003526-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|PIRSR:PIRSR000459-2};
CC Note=Binds 1 Ca(2+) ion per subunit. {ECO:0000256|PIRSR:PIRSR000459-2};
CC -!- SIMILARITY: Belongs to the transglutaminase superfamily.
CC Transglutaminase family. {ECO:0000256|ARBA:ARBA00005968}.
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DR EMBL; AXCN02000839; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A182Q5M1; -.
DR STRING; 69004.A0A182Q5M1; -.
DR EnsemblMetazoa; AFAF003526-RA; AFAF003526-PA; AFAF003526.
DR VEuPathDB; VectorBase:AFAF003526; -.
DR OrthoDB; 5344745at2759; -.
DR Proteomes; UP000075886; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003810; F:protein-glutamine gamma-glutamyltransferase activity; IEA:InterPro.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR Gene3D; 3.90.260.10; Transglutaminase-like; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR002931; Transglutaminase-like.
DR InterPro; IPR036985; Transglutaminase-like_sf.
DR InterPro; IPR023608; Transglutaminase_animal.
DR InterPro; IPR008958; Transglutaminase_C.
DR InterPro; IPR036238; Transglutaminase_C_sf.
DR InterPro; IPR001102; Transglutaminase_N.
DR PANTHER; PTHR11590; PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE; 1.
DR PANTHER; PTHR11590:SF69; RE08173P; 1.
DR Pfam; PF00927; Transglut_C; 1.
DR Pfam; PF01841; Transglut_core; 1.
DR Pfam; PF00868; Transglut_N; 1.
DR PIRSF; PIRSF000459; TGM_EBP42; 1.
DR SMART; SM00460; TGc; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF49309; Transglutaminase, two C-terminal domains; 2.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|PIRSR:PIRSR000459-2};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR000459-2}.
FT DOMAIN 315..409
FT /note="Transglutaminase-like"
FT /evidence="ECO:0000259|SMART:SM00460"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 323
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-1"
FT ACT_SITE 382
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-1"
FT ACT_SITE 406
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-1"
FT BINDING 446
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-2"
FT BINDING 448
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-2"
FT BINDING 496
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-2"
FT BINDING 501
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-2"
SQ SEQUENCE 749 AA; 82909 MW; E6E1021626FF570F CRC64;
MASKPKPKSY KIWPPRKASG NRSVKEPLCV ESVDLCFQEN GAAFHTASYE MMMKPRPTKR
PRQLVVRRGA PFLVRLICNR HLEPTADTMV LVLSVLPFNS ETVCFGNGTE TYVLVHANDG
GNGGPAEQPA DEWGAVLMGS QNKPKGKVEL TVSITTPSYS PIARWNMAVH CRLDTTDAKT
EFMLKEPIYL LYNPWCKEDA VYMEDEASRK EYVLDDSTMI CKPSAQGPRM TSWFLGQYEA
SVLDCVLYII SEVGNVQSAL SGNPVLVTRA LSGALNSASG FGVLQGNWSG NYENGTPPMS
WSGSVKILQE FFETKETVQF GQCWVYSGLF ATVCRSIGIP ARVITNFESA GDHDASLSID
YFLDDTDTVT SDMSVDSIWN YHVWIEGWMR RKDLQNSDFD GWQVLDATPQ QISDGMYKCG
PCPVGAIRLG HVHVPYDGEF IYAEVNADVI YWSIGNDQNP PKPLQIKTDQ IGRDMSTKAV
GSGQREDVTA QYKYPEGSPE ERDVMKTAMK FSCQRFCSAG LAKRLLGNMV SEVSADEDSI
TLHLKSSEEL VLGSTFQIEL TVTNRSAVGE VEVTGNLILK DSDYTGRLTE TLKKLPFAMK
LEAQETKSMV VPLDYKEYSQ TAKNKTNLKA TCMADVKGCN RTVFTMATFH LSPPAIELTP
IEHSVAGPLA VQVDMRNPLP VPLTGGRFVV EGSRFTDPIE KLYDFIPVDG TVQFIYPINL
SHKGKMVISA SFISNELKNV HGDVTLNIP
//
