ID A0A182Q740_9DIPT Unreviewed; 509 AA.
AC A0A182Q740;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=WD40 repeat-containing protein SMU1 {ECO:0000256|ARBA:ARBA00026184};
OS Anopheles farauti.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=69004 {ECO:0000313|EnsemblMetazoa:AFAF004372-PA, ECO:0000313|Proteomes:UP000075886};
RN [1] {ECO:0000313|Proteomes:UP000075886}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FAR1 {ECO:0000313|Proteomes:UP000075886};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles farauti FAR1 (V2).";
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AFAF004372-PA}
RP IDENTIFICATION.
RC STRAIN=FAR1 {ECO:0000313|EnsemblMetazoa:AFAF004372-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000256|ARBA:ARBA00004324}.
CC -!- SIMILARITY: Belongs to the WD repeat SMU1 family.
CC {ECO:0000256|ARBA:ARBA00025801}.
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DR EMBL; AXCN02001174; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A182Q740; -.
DR STRING; 69004.A0A182Q740; -.
DR EnsemblMetazoa; AFAF004372-RA; AFAF004372-PA; AFAF004372.
DR VEuPathDB; VectorBase:AFAF004372; -.
DR OrthoDB; 3893433at2759; -.
DR Proteomes; UP000075886; Unassembled WGS sequence.
DR GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:InterPro.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR006595; CTLH_C.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR006594; LisH.
DR InterPro; IPR045184; SMU1.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR22848; WD40 REPEAT PROTEIN; 1.
DR PANTHER; PTHR22848:SF0; WD40 REPEAT-CONTAINING PROTEIN SMU1; 1.
DR Pfam; PF17814; LisH_TPL; 1.
DR Pfam; PF00400; WD40; 5.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00668; CTLH; 1.
DR SMART; SM00667; LisH; 1.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50897; CTLH; 1.
DR PROSITE; PS50896; LISH; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 5.
DR PROSITE; PS50294; WD_REPEATS_REGION; 5.
PE 3: Inferred from homology;
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 40..92
FT /note="CTLH"
FT /evidence="ECO:0000259|PROSITE:PS50897"
FT REPEAT 210..251
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 260..301
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 303..344
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 345..386
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 476..509
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
SQ SEQUENCE 509 AA; 57061 MW; 07C2499859CB7F47 CRC64;
MSIEIESADV IRLIQQYLKE SNLHKTLQTL QEETGVSLNT VDSVEGFVSD IHNGHWDTVL
KAIQSLKLPD KKLIDLYEQI VLELIELREL GAARSLLRQT DPMIMLKQQE AERYIHLENM
LQRAYFDPRE AYPEGSSKEK RRAAIATALA GEVSVVPSSR LLALLGQALK WQQHQGLLPP
GTTIDLFRGK AAIRDQEDES YPTQLARQIK FGQKSHVECA LFSPDGQYLV TGSVDGFIEV
WNFTTGKIRK DLKYQAQDNF MMMEQAILSM AFSRDSEMLA TGSQDGQVKV WKLVTGQCLR
RFEKAHSKGV TCLHFSRDNS QILTASFDHL IRLYGLKSGK MLKEFRGHTS FVNEAVFSPD
GHHVLSASSD GTVKVWSLKT TECISTFKAL GTHLAVNSVL ILPKNPEHFV VCNRSNTVVI
MNMQGQIVRS FSSGKREGGA FICATISPRG EFIYCAGEDL VLYCFSVTSG KLERTLNVHE
KDVIGLTHHP HQNLLASYGC DGLLKMWKP
//
