ID A0A182QAJ0_9DIPT Unreviewed; 747 AA.
AC A0A182QAJ0;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE RecName: Full=Protein tweety homolog {ECO:0000256|RuleBase:RU361114};
OS Anopheles farauti.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=69004 {ECO:0000313|EnsemblMetazoa:AFAF006329-PA, ECO:0000313|Proteomes:UP000075886};
RN [1] {ECO:0000313|Proteomes:UP000075886}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FAR1 {ECO:0000313|Proteomes:UP000075886};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles farauti FAR1 (V2).";
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AFAF006329-PA}
RP IDENTIFICATION.
RC STRAIN=FAR1 {ECO:0000313|EnsemblMetazoa:AFAF006329-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- FUNCTION: Probable chloride channel. {ECO:0000256|RuleBase:RU361114}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU361114};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU361114}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the tweety family.
CC {ECO:0000256|ARBA:ARBA00009849, ECO:0000256|RuleBase:RU361114}.
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DR EMBL; AXCN02002234; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A182QAJ0; -.
DR EnsemblMetazoa; AFAF006329-RA; AFAF006329-PA; AFAF006329.
DR VEuPathDB; VectorBase:AFAF006329; -.
DR OrthoDB; 5393599at2759; -.
DR Proteomes; UP000075886; Unassembled WGS sequence.
DR GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005254; F:chloride channel activity; IEA:UniProtKB-UniRule.
DR CDD; cd07912; Tweety_N; 1.
DR InterPro; IPR006990; Tweety.
DR PANTHER; PTHR12424:SF8; PROTEIN TWEETY; 1.
DR PANTHER; PTHR12424; TWEETY-RELATED; 1.
DR Pfam; PF04906; Tweety; 1.
PE 3: Inferred from homology;
KW Chloride {ECO:0000256|RuleBase:RU361114};
KW Chloride channel {ECO:0000256|RuleBase:RU361114};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|RuleBase:RU361114};
KW Ion transport {ECO:0000256|RuleBase:RU361114};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361114};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361114};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361114};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361114}.
FT TRANSMEM 50..72
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361114"
FT TRANSMEM 92..111
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361114"
FT TRANSMEM 218..241
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361114"
FT TRANSMEM 248..270
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361114"
FT TRANSMEM 395..418
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361114"
FT REGION 529..577
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 591..747
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 531..554
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 610..628
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 638..653
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 654..676
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 747 AA; 80861 MW; 9519BC214FDDA57C CRC64;
MGYPGTTEDD DQYRVPLIAK LLHALPHYNI TFHRINNTFR PSDDVYLESL GILGSIPAAL
LIVSLFGLLL YLLTRCCDRK PRPAHSITSL KVTLSIVTVL CCAAIGLGLY GNDDLHNGLL
EVLQAGRKVD GVVSSVRNQT FILENTLTMK IQQQLSELED IFDQKTNNQT ALTQLQQALL
TAKGNITIAK NAANDIRRPL VGLTITDFLT KGDQWELIRW PGTVAILALL LVLCAVLLVG
VARHSRCALI LFSVCGLLAV TGSWLMSGLY LSASVAVGDL CNDPADFLVH QAPHELPADI
LLYYTQCDIS RSNPFTQRLR ESQNAINNAR NAMSIVSKIS PVLFKNAGLA PKLGSVNADV
KLCERLLTGL TALVDCRAVH YSYLVATRGL CEGGLLGLVL MLIASFMAAI LLTIMVWVDS
HTWIYIRKRN DYAQVEEQSY VSHQLHPQSH QNLNTRTLPH HPKGPPVISG SHTIAHPGRN
AKHDMNQVQQ TQQQMHHQQA HVQAQQAQAQ AQAHMMHHHQ AMMRTGGTHT LGRLPSHSSP
THLHGPNNGN KPLPSIINCP LPDIPKTSGN GGPTSKDDIY VKRKLLADHP NGSKFATLKP
IPAPKIEPNH LSGKQQQHQH SLSNGANGSD AAAPADLVSQ LPPPPPPPPP ATGNSSGSSG
GSSGYSTSGL TTSQIQSLPL PPPPLELLQQ HQHTHQDEQS LLLPPPPTSE ELEANGGTQQ
NGDGHDSVIG EKGGATDDNS FYAVTEL
//
