ID A0A182QAZ8_9DIPT Unreviewed; 695 AA.
AC A0A182QAZ8;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Equilibrative nucleoside transporter 4 {ECO:0008006|Google:ProtNLM};
OS Anopheles farauti.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=69004 {ECO:0000313|EnsemblMetazoa:AFAF006573-PA, ECO:0000313|Proteomes:UP000075886};
RN [1] {ECO:0000313|Proteomes:UP000075886}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FAR1 {ECO:0000313|Proteomes:UP000075886};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles farauti FAR1 (V2).";
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AFAF006573-PA}
RP IDENTIFICATION.
RC STRAIN=FAR1 {ECO:0000313|EnsemblMetazoa:AFAF006573-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
CC {ECO:0000256|ARBA:ARBA00007965}.
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DR EMBL; AXCN02001109; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A182QAZ8; -.
DR EnsemblMetazoa; AFAF006573-RA; AFAF006573-PA; AFAF006573.
DR VEuPathDB; VectorBase:AFAF006573; -.
DR OrthoDB; 2939652at2759; -.
DR Proteomes; UP000075886; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005337; F:nucleoside transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR002259; Eqnu_transpt.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR10332; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER; 1.
DR PANTHER; PTHR10332:SF89; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 4; 1.
DR Pfam; PF01733; Nucleoside_tran; 2.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 71..92
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 112..132
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 139..162
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 168..192
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 233..254
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 397..415
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 422..441
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 461..479
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 491..513
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 533..553
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 14..64
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 621..651
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 17..40
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 48..64
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 695 AA; 73339 MW; B0EA420B0666DBFB CRC64;
LRWTLFEARR KGHSTMMEAS ENGSSIGDGG RNSNGGGHTS SYEPLEGRRT FETSDSPELD
GGGPPKDRRR LVFFALMTAG VGFVLPYNSF IIAADYWQSR FPGQSVALDM SMTYIIVALA
TVLLNNVFLT LAPFRVRVAF GYAVSFTTLV FVALCEVAWH MFTAKTAYSV NLAAVSLVAM
GCTIQQSSFY GFASMLPKQY TQAVMAGESL AGFLVSSNRV VTKLLIKSDR ASTAIFFLTS
TVYIAFSYVL HSITTHSPFV RYYMKACAKI VLRPDDDHTL SETLDGDISS TRYGVLTLDA
SPPVHMPPGS TALSFSNPVY DLSNPTAGET MLETNMTNLA PGTTTATRAV TATTTAPDVP
NVAFKVEHVM TPDICSSGRL GSFRSGLESR WKVARAIYPY MACIAMAYCV TLSLYPGIES
EIISCNLGTW MPVLLMFTFN ASDVAGKLLA AVPYGWSRRQ LILMSGLRAL LVPLILLCCS
PREQPVIAGE AAAFIFTAAL GITNGLAGSL PMMLAPDKVS ATLREVTGNM MTLSYNIGLT
AGSLVGYVFD AMLGPQLPNP CPQYPFVPPK PNQPPTAGLG LINTSHPVAG SGGISSSSTS
TTVATTLLTT LTVAVMRSTV GAPPETSTIS PLTSTASNSA SGGGGSPAGF TTPIPTTSTT
SGVPAFDGAQ LATVAATLLY NATSSLLDSS AGALD
//
