ID A0A182QBR8_9DIPT Unreviewed; 1433 AA.
AC A0A182QBR8;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=Rab-GAP TBC domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Anopheles farauti.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=69004 {ECO:0000313|EnsemblMetazoa:AFAF007005-PA, ECO:0000313|Proteomes:UP000075886};
RN [1] {ECO:0000313|Proteomes:UP000075886}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FAR1 {ECO:0000313|Proteomes:UP000075886};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles farauti FAR1 (V2).";
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AFAF007005-PA}
RP IDENTIFICATION.
RC STRAIN=FAR1 {ECO:0000313|EnsemblMetazoa:AFAF007005-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AXCN02000488; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 69004.A0A182QBR8; -.
DR EnsemblMetazoa; AFAF007005-RA; AFAF007005-PA; AFAF007005.
DR VEuPathDB; VectorBase:AFAF007005; -.
DR OrthoDB; 2908929at2759; -.
DR Proteomes; UP000075886; Unassembled WGS sequence.
DR GO; GO:0051179; P:localization; IEA:UniProt.
DR CDD; cd01211; PTB_Rab6GAP; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.8.270; putative rabgap domain of human tbc1 domain family member 14 like domains; 1.
DR Gene3D; 1.10.10.750; Ypt/Rab-GAP domain of gyp1p, domain 1; 1.
DR Gene3D; 1.10.472.80; Ypt/Rab-GAP domain of gyp1p, domain 3; 1.
DR InterPro; IPR022164; Kinesin-like.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR006020; PTB/PI_dom.
DR InterPro; IPR000195; Rab-GAP-TBC_dom.
DR InterPro; IPR035969; Rab-GAP_TBC_sf.
DR PANTHER; PTHR47219:SF9; GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B; 1.
DR PANTHER; PTHR47219; RAB GTPASE-ACTIVATING PROTEIN 1-LIKE; 1.
DR Pfam; PF12473; DUF3694; 1.
DR Pfam; PF00566; RabGAP-TBC; 1.
DR SMART; SM00462; PTB; 1.
DR SMART; SM00164; TBC; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47923; Ypt/Rab-GAP domain of gyp1p; 2.
DR PROSITE; PS01179; PID; 1.
DR PROSITE; PS50086; TBC_RABGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}.
FT DOMAIN 427..505
FT /note="PID"
FT /evidence="ECO:0000259|PROSITE:PS01179"
FT DOMAIN 863..1049
FT /note="Rab-GAP TBC"
FT /evidence="ECO:0000259|PROSITE:PS50086"
FT REGION 1..158
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 325..345
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 634..660
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1384..1406
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1109..1196
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1267..1294
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..41
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 75..109
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 638..660
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1384..1400
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1433 AA; 156286 MW; F4E7EA836FA0491D CRC64;
MEKQPGSRAA QNSNKSSSVS PATAEAVATK KNHSREPSIT SGPSKGGGAI PCAGIEEIKS
SDKPSVHPDS TSGIGGGVTP DTQLVDTSLG PKSEDSLSIK SSDSVTTSGE YEIVPEAPSP
GEDLPDSGVT RSPPLGDRDC EGEPIRSTTA NGNSAGDIGA DLAECIADDG VPTEQKDALI
RKQRAAEGKK LSAISPILNI EGNGNMMDLE KNMNEVIHEL EEERTLSGAS DPSSSNKATP
VRCPAMLATA SDQPRVDGDN VPLKKPQVPT SLRLGLQSMV RANFTVGGDG STETTPNALL
SPEAIGRGVG QSVFYDCLDS SPMTEKKDDM KPVGGGAGGV GAGGETDDEL SDIDQDCTIF
SGVTYLGASR INAPKSEREI LQKVSEMNGG VGGVLGGASG APDCSGSDSP LGLKVSVSIP
TCSEGLVVLY DCESNAVVAT YEVQRILFFA RGPVGSTDQA CFAFTWSHGE SQETAVHQCH
VFRCNIPEAV TQVSTCFAKA FQRVLPPSIP ASMTTSLAES GMNVMLASVT SDTAGNPIQS
AMYEFAVSLE IKEKERNSSY VTVPRDVKSS FRLRSKTDKE VCITVRQVPS DRFPSLLIER
CFGVLLSPGR IVRQADMQLL DMVSMGYVKP PEGNASAPIG SGTGSSSSNS NATNGSSSAA
GAAGGGASAA NFSQFPYQIK AEWKAHAFEP LNMETPKKAL TVAVDLVIKG IQEPVRFIIE
TSVAILSQSE LRIVPNMFSN KRPLLLHFYL TLRENGEGTW EVESIDHSDE IVEPQATSSL
NFYFKNWTFR TSASVQSMQE VFDDPSPTDY SSDGDEPLLS GTGEVSKNCS AAQLDEWQGI
IMEWYQEGPE KRPKNLPNLV RMGIPEALRG TVWQRLACVE NRTEMFDSYR VLITKETNCE
TVIQRDINRT FPAHKFFKEN GGTGQENLYK VSKAYAVYDT EVGYCQGLSF IAASLLLHMP
EEEAFCVLVA LMYNYGLRDM YKMGFESLYL RLYQLNRLMK DQLPDLYEHF VQMGVESHMF
ASQWFLTLFT ARFPLYFVFY ILDVFLLDGI PVLFQVALTL LNVCRKDLLE LDFEGILKYF
RVTLPKKCRS ETQAKKLMKL SFECKVKKLK KYELEYLAKK EETERKEQEL KQYEQRYGEE
RSKLQQEIAT LNERLEAMGR EDRKNAGIIQ DYKRIIQRQE AENGKLHAML DDLTKTVSSC
SKCTASIPQS SPLHKSYGKN FQQANTVNNN NEQLAHPLAD QPDGGTSIGK NVNASASIAG
LGPLDPLVIA SQRIRELELE LAQTKLAQVE AECKNQDLHH QLNTTVTELQ ATRSSWQPWL
SKTLNSIQEK VATKRDINPS APTFQSYASS EANLKNQSHT LPHVRNNNHK ATLAQRHSVA
QVNFPQSVNH STTAAGTATT DADGNDEPAV LARAKYDSSV NILYKDSRCN SLK
//
