ID A0A182QC38_9DIPT Unreviewed; 1355 AA.
AC A0A182QC38;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=MAGUK p55 subfamily member 5 {ECO:0000256|ARBA:ARBA00032294};
OS Anopheles farauti.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=69004 {ECO:0000313|EnsemblMetazoa:AFAF007196-PA, ECO:0000313|Proteomes:UP000075886};
RN [1] {ECO:0000313|Proteomes:UP000075886}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FAR1 {ECO:0000313|Proteomes:UP000075886};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles farauti FAR1 (V2).";
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AFAF007196-PA}
RP IDENTIFICATION.
RC STRAIN=FAR1 {ECO:0000313|EnsemblMetazoa:AFAF007196-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Apical cell membrane
CC {ECO:0000256|ARBA:ARBA00004221}. Cell junction, adherens junction
CC {ECO:0000256|ARBA:ARBA00004536}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004236}. Cell projection, axon
CC {ECO:0000256|ARBA:ARBA00004489}. Endomembrane system
CC {ECO:0000256|ARBA:ARBA00004184}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004184}. Golgi apparatus
CC {ECO:0000256|ARBA:ARBA00004555}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}. Perikaryon
CC {ECO:0000256|ARBA:ARBA00004484}.
CC -!- SIMILARITY: Belongs to the MAGUK family.
CC {ECO:0000256|ARBA:ARBA00007014}.
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DR EMBL; AXCN02001476; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 69004.A0A182QC38; -.
DR EnsemblMetazoa; AFAF007196-RA; AFAF007196-PA; AFAF007196.
DR VEuPathDB; VectorBase:AFAF007196; -.
DR OrthoDB; 2873706at2759; -.
DR Proteomes; UP000075886; Unassembled WGS sequence.
DR GO; GO:0005912; C:adherens junction; IEA:UniProtKB-SubCell.
DR GO; GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030424; C:axon; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0043204; C:perikaryon; IEA:UniProtKB-SubCell.
DR CDD; cd00071; GMPK; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd12036; SH3_MPP5; 1.
DR Gene3D; 1.20.1270.460; -; 1.
DR Gene3D; 2.30.42.10; -; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR020590; Guanylate_kinase_CS.
DR InterPro; IPR014775; L27_C.
DR InterPro; IPR004172; L27_dom.
DR InterPro; IPR035601; MPP5_SH3.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23122; MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK; 1.
DR PANTHER; PTHR23122:SF14; PROTEIN PALS1; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF02828; L27; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF07653; SH3_2; 1.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM00228; PDZ; 2.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 2.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS00856; GUANYLATE_KINASE_1; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS51022; L27; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 784..840
FT /note="L27"
FT /evidence="ECO:0000259|PROSITE:PS51022"
FT DOMAIN 917..996
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1009..1080
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 1159..1339
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
FT REGION 256..303
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 392..462
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 487..519
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 553..609
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 396..414
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 434..462
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 487..504
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 559..577
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1355 AA; 148152 MW; C85FA2B6F5906B13 CRC64;
MQQRTTTPAG PPTASSSGKQ VVELNGYVII LVESRDGKIK LYGSPADKDN LEVADEILDV
NERKLEDSPR AEVIKHIHEC IQSCMIKLRV KRRSDSRLAG ELGNAVQDAF VIAVEQQARE
RLQRLSALKR ITPLNQQSQA KGGATQDLSF LKEASPIYVT SLSAVPSGAT VATNNNNTVA
AGVTGAASAA STSAYHTSTL HHSLVNNNNL NSNIGKPQGG GGLDSTANSY YSNLTNTFLA
NGHGSKREQL ATLSEGELEP QDEPQYESSG NISRGGTEVL LGDQNLRQES RPRRRSGSSI
VVLGGDDTLK PSIPIDDYQE DLEMYNMLAA NQDNGPHREM AVDVPESFIA RNKTPPRYPP
PRSASAAVAA TTAAPATPAS TQVIHVSNAM PQVAKHHQQQ HHHHQHHHHP HHHPAANGGG
VSLELEPLDS YSDRHLSSLD SSQECVKKGG SSKGPSSLGS VTSEFDPLSV SLTNGYGHQL
RKHANDLRGS LSTNRSTSPS SSGDLGPPEY DVGPHRELPV DVPDSFVEIV KGPPRYPPPK
PLIIKDVIRK KESCSSSESI DKPKPQSPQS PARNELNGST KPVPPPRDHL RIEKDGRLTN
RAPVPAPQVP DRKIAPIASQ HQHIGQVLEP TPDQLDSIKK FQEQLRRRRE DEERIAAQND
FLRNSLRGSQ RLRALQDNPI EKPPVGVDNE AYAEDEVVEK IIGMHHLRWV PSDGNLIRTF
ARPFTGYSEL VAALQRLQGH LNKHGLATLA GRVTAAQSLL LGPGIARALA VRTAVLERRR
PKVPNPICPN AQALAKDCVE SLAQSGSPTA IELCDLLSTY EMEGLLLAHD RIASTTDRSP
IASYGGSPVT VPMPSLSNNI NNNNTLTSAA VKPATVMPSI PNNASLVNNN NNNIAKREPM
SVPLGVLRDG SQDHIKIIQI EKSSEPLGAT IRNEGEAVVI GRVVRGGAAE KSGLLHEGDE
ILEVNGIEMR GKSVNDVCAL LGSMTGTLTF LVVPAGVPQI LPGLGMRDPP VLHVRAHFDY
DPEDDLYIPC RELGISFQKG DVLHVISRDD PNWWQAYREG EEDQTLAGLI PSQSFQHQRE
SMKLAIAGEV GLRTRKDING KAGGGSTLLC ARKGRKKKKK ASSEHGYPLY ATATADDPDP
EEILTYEEVA LYYPRASHKR PIVLIGPPNI GRHELRQRLM ADSERFAAAI PHTSRAQREG
EVPGQDYHFI SRQQFESDIL ARKFVEHGEY EKAYYGTSLE AIRAVVASGK ICVLNLHPQS
LKLLRSSDLK PYTVLVAPPS LEKLRQKRIR TGEPYKEEEL KEIIATARDM EARWGHLFDM
IIINNDTERA YHQLLAEINS LEREPQWVPS SWLHN
//
