ID A0A182QEY1_9DIPT Unreviewed; 1724 AA.
AC A0A182QEY1;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Down syndrome cell adhesion molecule {ECO:0008006|Google:ProtNLM};
OS Anopheles farauti.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=69004 {ECO:0000313|EnsemblMetazoa:AFAF008791-PA, ECO:0000313|Proteomes:UP000075886};
RN [1] {ECO:0000313|Proteomes:UP000075886}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FAR1 {ECO:0000313|Proteomes:UP000075886};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles farauti FAR1 (V2).";
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AFAF008791-PA}
RP IDENTIFICATION.
RC STRAIN=FAR1 {ECO:0000313|EnsemblMetazoa:AFAF008791-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR EMBL; AXCN02000424; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 69004.A0A182QEY1; -.
DR EnsemblMetazoa; AFAF008791-RA; AFAF008791-PA; AFAF008791.
DR VEuPathDB; VectorBase:AFAF008791; -.
DR OrthoDB; 4503820at2759; -.
DR Proteomes; UP000075886; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProt.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd00063; FN3; 6.
DR CDD; cd20957; IgC2_3_Dscam; 1.
DR CDD; cd20956; IgI_4_Dscam; 1.
DR CDD; cd20958; IgI_5_Dscam; 1.
DR CDD; cd20954; IgI_7_Dscam; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 15.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR PANTHER; PTHR44170:SF48; MYOPALLADIN; 1.
DR PANTHER; PTHR44170; PROTEIN SIDEKICK; 1.
DR Pfam; PF00041; fn3; 6.
DR Pfam; PF07679; I-set; 3.
DR Pfam; PF13927; Ig_3; 5.
DR PRINTS; PR00014; FNTYPEIII.
DR SMART; SM00060; FN3; 6.
DR SMART; SM00409; IG; 9.
DR SMART; SM00408; IGc2; 8.
DR SUPFAM; SSF49265; Fibronectin type III; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 9.
DR PROSITE; PS50853; FN3; 6.
DR PROSITE; PS50835; IG_LIKE; 9.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1483..1504
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..80
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 97..187
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 191..278
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 284..377
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 382..468
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 473..566
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 569..656
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 666..761
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 770..864
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 869..975
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 980..1075
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1079..1174
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1176..1264
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1266..1359
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1360..1457
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 1543..1724
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1543..1559
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1568..1582
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1620..1658
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1678..1724
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1724 AA; 191735 MW; 401060E48CEE9F06 CRC64;
MSGNTAVLKC QVPSYIQDYV VVTAWVQDSG VHLYPNTDIG GKYIVLSNGD LYINNAGASD
AYKTYSCRTV NRLTGEIQIS TYPGRVIVTE PKGLVQPRIN VEKHSLKHVV VNAPVTLPCV
AQGHPVPTYR WFKEVKDQIL PLQLNERISI VSAGLLKIAK ARLEDSGKYL CWVNNTAGEE
TIQVSLTVTA PLTAHLQPQV QTVDVGKDAQ FQCIISGFPA HEVLWMHNGK PIVRDSRIEI
YTDAPRIVIK SVQKEDQGMY QCFVANEWEQ IQSTAELQLG DATPELLYWF SEQTLQPGPT
VSLKCVGTGN PPPQFTWKLD GFPIPDSPRF VVGQYVTIHD DVISHVNISN VKEEDGGEYT
CVAQNSIGKV SHSAKVNIYG LPYIREMPKI TGVSGHDLII KCPVAGYPID KIHWERDGQT
LPINRRQRAY NNGTLIIEQL QLAEDAGTYT CMAQSKQKQT ARRNVEIQVI VPPKIMPIQA
MTNMLREGMR AAISCQILEG DLPVNFRWER NGKPVLGTGN EVIRRLDEYS TSLVIEHITS
EYSGNYTCIA SNVAGSESFT VPLTVNVPPK WILEPKDSSA QAGQDVALHC QAGGHPQPTV
TWKKAIGNTP GEYKDFLYEP NVKLHPNGTL QFRKIAKDSQ GHFLCEAKNS IGTGVSKVIF
LKVNVPAHFS TKNKQITSPR NKQIHIQCNV QGDNPIDIKW KMQSSQQQLD ESLDNRYNIR
EQVLDDGMVS ELGISHTYRQ DTGVYVCQAS NAFGQDEMSI HLVIQEVPEA PKNLRINSQQ
SRTLQLSWSQ PFAGNSPIEK YNVEYKLVTE PWQSAEHITV AGTQTVITLQ NLKPAKAYHL
RISAENKLGA SEYSEVIQVT TLEEVPSGPP LNIKGEPKSS TEIFLSWEAP DRDQWNGNLL
GYYVGYQIAS SPNDREINPT QGFNFKTVEV RSHFGGETTL QNLNKCTTYN IVVQAYTSQG
SGPPSKEISL GTLEDVPSSA PDSPKCDVLS STSIYITWSP PPVDGQNGKI RGYKVSYIEM
DDLYEKEPYT SKTNNQYLTL ESLKKFTNYT FWVLAFTKVG DGVRTNPFHC ITQEDVPSAP
SALKAVPSSS SKVIISWLPP AHRNGIITGY TFYMSLVDGG RDEGTHKRSL VPYAESHETV
RLQEQATYQF WLTASTKVGE GEKSEVIKVL PNNKVPARIV SFSQEIVTPW KETLVLPCRK
VGVPAPVTIW RQDEQAMDTG TRKLIAKNGT LYIKDCQHSD AGNYTCSVEN TWGRDEIVYR
IRIRVPPDPP TLTIVNTYTD SLLLEWTDNR NGGSPVLGYV INYKRENGDW EELQIDSKTN
THLLVNLWCG TRYQLYITAY NKIGTGLPCD IVHSHTKGLP PVQPKHSQMI TNNSTSVTCW
LDSWGDGGCG ILHFSIENRQ YGRPQWNMIA SHVEATERIF TVTDLQPASK YQLRVTAYNN
AGATMAVYNY TTLTAQGVMV YPDITNPVSP HMGENPFYAN VKVILPLCLS ILILFALVAA
ALLIRKRKLN NQNRIPSTSM SESPSIANIQ NKHNRDQQYL AVRAQQASRN SNSVDSGSYK
AEGNEYDTLG SESDNDIASR SNQSNYRHHR DTQDETSSSS ENSPSSISRK SKPPYPPRKS
AKAQSQNLPK RHVRSSSGYS SHNEETTFSI SNYPNYSDHI TPPARFSDLL GRGDATLAVS
SVNPSSLGSA TEIGSNVAGK KSSNHSPRPR ANQKLQREAF QINV
//
