ID   A0A182QH57_9DIPT        Unreviewed;       922 AA.
AC   A0A182QH57;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   22-FEB-2023, entry version 26.
DE   RecName: Full=DH domain-containing protein {ECO:0000259|PROSITE:PS50010};
OS   Anopheles farauti.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=69004 {ECO:0000313|EnsemblMetazoa:AFAF010084-PA, ECO:0000313|Proteomes:UP000075886};
RN   [1] {ECO:0000313|Proteomes:UP000075886}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FAR1 {ECO:0000313|Proteomes:UP000075886};
RG   The Broad Institute Genomics Platform;
RA   Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Anopheles farauti FAR1 (V2).";
RL   Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:AFAF010084-PA}
RP   IDENTIFICATION.
RC   STRAIN=FAR1 {ECO:0000313|EnsemblMetazoa:AFAF010084-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
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DR   EMBL; AXCN02002163; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AXCN02002164; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 69004.A0A182QH57; -.
DR   EnsemblMetazoa; AFAF010084-RA; AFAF010084-PA; AFAF010084.
DR   VEuPathDB; VectorBase:AFAF010084; -.
DR   OrthoDB; 2916834at2759; -.
DR   Proteomes; UP000075886; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   InterPro; IPR039919; ARHGEF10/ARHGEF17.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   PANTHER; PTHR12877; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   PANTHER; PTHR12877:SF7; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 10-LIKE PROTEIN; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   Pfam; PF19056; WD40_2; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   PROSITE; PS50010; DH_2; 1.
PE   4: Predicted;
FT   DOMAIN          50..236
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   REGION          762..810
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          834..922
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        762..786
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        834..872
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        873..897
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        898..922
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   922 AA;  105242 MW;  05206A709E887577 CRC64;
     MARETSLTKP LPLALNEKMS ASNYSPLSCH SLKRIVLKPL AEEVTDYRKK RWLAFGQFIL
     HEQNYLEALH KLQYEMYNVL MLDDTIVRRE VSYTIFSTHK KICQLHQHYN RMLETCAARW
     SEEGLVGWLL WAMLEEPLFE TLYTKFTINY LAMVAVFHEE RERNAAFAAF VATKLKQFGE
     RLTFDEYFVK PVQRIPHLIV EIKDLMERTP CDLPDWAVLR RCRTRIEQIA SQINTLQGNI
     VMVPVLLGAM ERSKRVKEDE LLHDRHSCRL LHSALLEESV QHTYRRRRSC KQRLVLLMSD
     RLVCLKLTDA DLHGTAECLV PQANKINSIK WILPLQQLQY GTAEQPVSCE EVIKYVNDYE
     TMLKIKQTMT ALHGAYDTVN RKVIADSMET IRRTVLRLER MPASLLVLTP IPSDNWSQVK
     RTLVLRDRYM RNEWQHKIRM AQLALRATNS PAWWNNCMHA AQERQDPLFV RTFKLVGLQT
     LLWKVTTGCC FAPSTDSAAY SRLLLRAWSQ HTNVVWLGAE DTLGNSIVTL LTHHRSTNQV
     EERATIPFER TVIHAIVHVP VGRVGNNPPD TVWLAASDQL LIYSATYPFV KIQLAQIQLT
     GAHRTLFYHK QRVYVGALDG VLNVFWLDSN GAWVLDAPVW SELSGGHIRA MMALGGSVYI
     AAGSKLHVFD GHDDAQPVRT FQVVATGEDK VADIRLLAHS ANGIWLVRCE SRVISLYTAT
     SHQHLIDINV TEHVLRFLAE YEHPGIVGAV FPGMISITSL LDMKRQDSKP QPSKAPATSA
     DPAKTSTSKD SGKKVKNTSK HPLAPNSMLI VTGGKGYVNW CDEEKEQEKQ KEKQKEKEKE
     KEKEKEKEKE KEKEKEKEKE KEKEKXXXXE GEGEGEGEGE GEGEGEGEGE GEGEGEGEGE
     RPEAYGREVH NHEPPEEHHQ TT
//