ID A0A182QIA0_9DIPT Unreviewed; 996 AA.
AC A0A182QIA0;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 16-JAN-2019, sequence version 2.
DT 22-FEB-2023, entry version 32.
DE RecName: Full=Dynamin-like 120 kDa protein, mitochondrial {ECO:0000256|ARBA:ARBA00018307};
DE EC=3.6.5.5 {ECO:0000256|ARBA:ARBA00011980};
OS Anopheles farauti.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=69004 {ECO:0000313|EnsemblMetazoa:AFAF010723-PA, ECO:0000313|Proteomes:UP000075886};
RN [1] {ECO:0000313|Proteomes:UP000075886}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FAR1 {ECO:0000313|Proteomes:UP000075886};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles farauti FAR1 (V2).";
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AFAF010723-PA}
RP IDENTIFICATION.
RC STRAIN=FAR1 {ECO:0000313|EnsemblMetazoa:AFAF010723-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.5;
CC Evidence={ECO:0000256|ARBA:ARBA00001837};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}. Mitochondrion
CC inner membrane {ECO:0000256|ARBA:ARBA00004434}; Single-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004434}. Mitochondrion membrane
CC {ECO:0000256|ARBA:ARBA00004325}.
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DR EMBL; AXCN02001792; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A182QIA0; -.
DR STRING; 69004.A0A182QIA0; -.
DR EnsemblMetazoa; AFAF010723-RA; AFAF010723-PA; AFAF010723.
DR VEuPathDB; VectorBase:AFAF010723; -.
DR OrthoDB; 48011at2759; -.
DR Proteomes; UP000075886; Unassembled WGS sequence.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR CDD; cd08771; DLP_1; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR022812; Dynamin.
DR InterPro; IPR001401; Dynamin_GTPase.
DR InterPro; IPR045063; Dynamin_N.
DR InterPro; IPR030381; G_DYNAMIN_dom.
DR InterPro; IPR045817; OPA1_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11566; DYNAMIN; 1.
DR PANTHER; PTHR11566:SF67; DYNAMIN-LIKE 120 KDA PROTEIN, MITOCHONDRIAL; 1.
DR Pfam; PF00350; Dynamin_N; 1.
DR Pfam; PF19434; OPA1_C; 1.
DR PRINTS; PR00195; DYNAMIN.
DR SMART; SM00053; DYNc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51718; G_DYNAMIN_2; 1.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00022792};
KW Transit peptide {ECO:0000256|ARBA:ARBA00022946};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 321..596
FT /note="Dynamin-type G"
FT /evidence="ECO:0000259|PROSITE:PS51718"
FT COILED 235..287
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 932..991
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 996 AA; 115040 MW; 61AC986C25D03894 CRC64;
MAQLLRGWSS IDPRFRQIRP VAYTAVSRVN FSGFTTADKG NGAGGNGGGS CHSTAWSRYN
YYRQQEFLRP PNASGWQYSY GGHRNYGMLL GRVLRGVLKL RYLVLGGAIG GGVTLNKRYE
EWKDGLPDMK WLEEVLPDNE KWAGFTKNLL AVKDAVKDSI EIDPRLKQLS EHKINEWRQW
FDQRLDNAIE AAETQQNPQI ESSFQNLSEF ISELYGATKE ELRAKNTVNA KGLGAEDSRK
RVDTLQAQVD SLQTEIMNVQ LKYQREVEKL EKENRDLRQQ YLILKTNRKQ PTKKRIKKSL
IDMYSEVLDE LSGYDTSYTT ADHLPRVVVV GDQSSGKTSV LESIAQARIF PRGSGEMMTR
APVKVTLSEG PYHVAQFRDS EREYDLTKES DLSDLRREVE IRMRNSVRGG KTVSMDVISM
TVKGPGLQRM VLVDLPGIIS TQTVDMAPDT RDQIKHMTEH YMSNPNAIIL CIQDGSVDAE
RSNVTDLVSQ CDPLGKRTIF VLTKVDLAED LADPNRIRKI LSGKLFPMKA LGYFAVVTGR
GRKDDSIETI REYEEKFFKN SKLFQSGVTM SHQVTTRNLS LAVADRFWKM VRETIEQQAD
AFKATRFNLE TEWKNNFPRL RESGRDELFE KAKGEVLDEV VNLSQVSAKK WEELMNTKLW
EKLSSYVFEN IYLPAAQSGS QNSFNTMVDI KLRQWAEQAL PAKSVEAGWE ALQKEFQHLM
EVARRTPDHD DLYDNLKSAV IDEAIRRHSW EDKAIDMLRV IQLNTLEDRS VHDKQEWDQA
VRFFEASVKD KLLATEKTIG EMFGPSTSQK WLQWRSSTED QNKRRQVKSE LDKILDSDTK
HSPTLSYDEL TTVRKNLQRC NVEVETDYIR ETWYPIYRRH FLKQALNRAY DCRKAYYLYS
QQGNDCEINC SDVVLFWRIQ QVIKVTANAL RQQVINREAR RLDKEIKEVL DEYGEDDEKK
QQLLTGKRVQ LAEELIRVRQ IQEKLEEFIN ALNLEK
//
