ID A0A182QIR2_9DIPT Unreviewed; 1860 AA.
AC A0A182QIR2;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Connector enhancer of kinase suppressor of ras {ECO:0008006|Google:ProtNLM};
OS Anopheles farauti.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=69004 {ECO:0000313|EnsemblMetazoa:AFAF011019-PA, ECO:0000313|Proteomes:UP000075886};
RN [1] {ECO:0000313|Proteomes:UP000075886}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FAR1 {ECO:0000313|Proteomes:UP000075886};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles farauti FAR1 (V2).";
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AFAF011019-PA}
RP IDENTIFICATION.
RC STRAIN=FAR1 {ECO:0000313|EnsemblMetazoa:AFAF011019-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the CNKSR family.
CC {ECO:0000256|ARBA:ARBA00009498}.
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DR EMBL; AXCN02000829; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 69004.A0A182QIR2; -.
DR EnsemblMetazoa; AFAF011019-RA; AFAF011019-PA; AFAF011019.
DR VEuPathDB; VectorBase:AFAF011019; -.
DR OrthoDB; 5406576at2759; -.
DR Proteomes; UP000075886; Unassembled WGS sequence.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd09511; SAM_CNK1_2_3-suppressor; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR049628; CNK1-3_SAM.
DR InterPro; IPR017874; CRIC_domain.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR PANTHER; PTHR12844; CONNECTOR ENCHANCER OF KINASE SUPPRESSOR OF RAS; 1.
DR PANTHER; PTHR12844:SF42; CONNECTOR ENHANCER OF KSR PROTEIN CNK; 1.
DR Pfam; PF10534; CRIC_ras_sig; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF07647; SAM_2; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS51290; CRIC; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 3: Inferred from homology;
FT DOMAIN 9..74
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 82..167
FT /note="CRIC"
FT /evidence="ECO:0000259|PROSITE:PS51290"
FT DOMAIN 204..284
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 870..968
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 588..618
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 673..719
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 747..816
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1016..1051
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1065..1097
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1181..1207
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1326..1347
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1391..1472
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1534..1556
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1650..1688
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 789..809
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1069..1097
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1190..1207
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1330..1346
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1400..1442
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1534..1552
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1650..1668
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1860 AA; 198737 MW; A8CA2ACBC206CF4A CRC64;
MAYINVAEWN TDMVTDWLKG LDNSMYHYVQ SFTNNGVGGK QLLNIRPYEL EQLGMHIIGH
QEIVLEAVEN LKNFHYNLDR ENLQFLALHV ATAAHSLEKQ LEFSDQEKLE TAVLKDITRT
ITHLKALIEW LDRAPFRGQK KFDELRKQCM RFGLEVATVA MRDRFSLMPV QAIRQNAKKL
AKIGEYIIKD IMDPIILQPA SLVLVTLKKR ESDLGFLIMQ SFHGVHRITE IKFNSPAHNS
GKVEDGDEIV QINYQAVVGW EYKKVLLELQ ESPPDVILTL KKRPKHMKIY GQIYMKPYPF
PSRRFFLMGW SESLPSPRVT DTFALQDFSL PLERVPEKQV PSDTESDGSD ILTPTDVKEV
EKEIRLYLPK PRAVLQRRHT LSNFKDLVGL ASWHEQRKGK PLLSSDLQSL RDKSVSFGFG
LEMSPRPTTT CLGLGGGGTG GGGGGAGGGG GAVTVVESGT GAAKCSSFGG LKCSLPDIVP
HETDAFVVPP NDRAIVDAKP PGAARREEGE NEAYKAGVSK MVRFESSSKA DQCHVDTKYT
CKVDNTVLET FEPIPYVDED LPMAPSVVSP PTVTERVKRF ESFANRTAAL TNGQHGGSTS
NTSATGGHNS SSVGTVAKPI PMQRQLSKDP ELAEAINTVV VNREMVKRGR LDKSYSTPAY
DDELSDVPPA IEPRKEHLLK APPVPPPRPK RTLEPMGSVP SEKAPTLAPP APVTSLSEPN
ASAGFVSSLS NTLDSREDSP NKSKLANVID LKQNRTQPPL PPSIATTPAS ITPPKPAERT
TSAPPIPALR PAATVPPAKP VPSGATESPL PPSTPTVSSA AAAAACVPSL PTADASSELL
TPNKTKSLTL KKKNSLMSKR RNVSLKTLCV SDIQGHLYRR TKDRSGMSYW AKYYFVLIET
TLYGFRSKEA PKANSMIFLT GFTITLAKEV HSRPHAFKVY HPNKTFYFAA ETQEALVQWM
EYIKQATLKG ASGLSGGATG TTPNASEQHN VRELFSETDS SDDELGLMDS SMKLNLLCTP
SPQMPTGSGA GPRDGMAADG ATPTSSKSDR YHLNFGSLKK FTKIGSDGGS GGNGATGSGS
AGHTGNSSGG GTSSNSNGEG SKFFGFFSSH RSVEKSNSSE MPVPTSQFKS YRKVPGAGGG
LQIGTAAVST EVFPMLNAPT DGAAGAVGGG NLRASNLSLA SGAGEKPTAP AVVPQPPPRA
VTPPTPPVII REPPMTPTIS EAAELLNRAR KTKRISPHNY IHASNPNLVE FDFQTSKAMD
FSVPKIHAAN TWDTSTHSHN NLQSMITLKD LMLQKQAEEA QDMYNKRVCL GVEKLDDRKA
RLAAGAAAST EQVQPPQQTN AAPAIPESVN KIQRRQLPIT PDYAQSFKLD DEDILYTRSK
EGQKLRDFGY EMISGDDPFD QRSNKPSGAS GNGGGNASNA SNIGTGTNGG TNGISSGGGG
SIKKKTFNWI NPDRRGDSSA HDSSAGSLAI GSAPSSSSLF AGGASGSSGT GGGGGGGLAT
SLSLRDSFKR TKNKAVIARL DNIKASSEKL FQFKQSSSSA GGSGANSNND KESLKTKQLD
KVAAPGTAMN VNLKHQPSQQ HQHQSQHPLT PFASIVGGLG GKKNNNELHA VLEQHSALLF
GHSVAASGSG VTHGGPSSTF VSGIKKSNTC NSSSDFKENS SKLQNMRKNS APERGVGGGG
GGSGTGAGGG TAGTSYFTKL SFGSTKTAKE KKLLGSPGLH RAIFGKNHHY NHGNDGQPTV
IDHEVFSPIS YTKAPAAAPS SDSASSPMVS VAMTTGMVPV GVSNPSQPMV PASSTSSTVL
MPNYGPNLAA VSRNSPDYPN MEYPPVFEPE TYSLSDPNAS LTLLKRRQNH HHHPHHQHQK
//
