GenomeNet

Database: UniProt
Entry: A0A182QKY2_9DIPT
LinkDB: A0A182QKY2_9DIPT
Original site: A0A182QKY2_9DIPT 
ID   A0A182QKY2_9DIPT        Unreviewed;      5013 AA.
AC   A0A182QKY2;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   23-MAY-2018, entry version 11.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|VectorBase:AFAF012298-PA};
OS   Anopheles farauti.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicoidea;
OC   Culicidae; Anophelinae; Anopheles.
OX   NCBI_TaxID=69004 {ECO:0000313|Proteomes:UP000075886, ECO:0000313|VectorBase:AFAF012298-PA};
RN   [1] {ECO:0000313|Proteomes:UP000075886, ECO:0000313|VectorBase:AFAF012298-PA}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FAR1 {ECO:0000313|Proteomes:UP000075886,
RC   ECO:0000313|VectorBase:AFAF012298-PA};
RG   The Broad Institute Genomics Platform;
RA   Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W.,
RA   Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B.,
RA   Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA   Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C.,
RA   Murphy C., Pearson M., Poon T.W., Priest M., Roberts A., Saif S.,
RA   Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Anopheles farauti FAR1 (V2).";
RL   Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|VectorBase:AFAF012298-PA}
RP   IDENTIFICATION.
RC   STRAIN=FAR1 {ECO:0000313|VectorBase:AFAF012298-PA};
RG   VectorBase;
RL   Submitted (JUN-2016) to UniProtKB.
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DR   EMBL; AXCN02001786; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   VectorBase; AFAF012298-RA; AFAF012298-PA; AFAF012298.
DR   Proteomes; UP000075886; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 2.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000075886};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000075886};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4340   4360       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4527   4548       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4618   4640       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4808   4830       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4886   4909       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       94    148       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      155    200       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      210    264       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      270    328       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      336    394       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      577    803       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1400   1625       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   COILED      460    480       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   5013 AA;  566562 MW;  A25A1B09DF05F89F CRC64;
     MAEAEGGSEQ DDVSFLRTED MVCLSCTATG ERVCLAAEGF GNRHCFLENI ADKNIPPDLS
     QCVFVIEQAL SVRALQELVT AAGSETGKGT GSGHRTLLYG NAILLRHNNS DMYLACLSTS
     SSNDKLSFDV GLQEHSQGEA CWWTVHPASK QRSEGEKVRV GDDLILVSVA TERYLHTTKE
     NDLSIVNASF HVTHWSVQPY GTGISRMKYV GYVFGGDVLR FFHGGDECLT IPSTWSLDQG
     QNIVVYEGGS VMSQARSLWR LELARTKWAG GFINWSHPMR IRHLTTGRYL GVNENNELIL
     MSRDQATTSQ TAFVLRLEKD DQKVVLEDKD LEIIGAPIIK YGDSTVIMQH YESGLWVSYK
     SYETKKKGVG KVEEKQAILH EEGKMDDGLD FSRSQEEESR TARVIRKCSS LFTKFISGLE
     TLQENRRHSI FLQTVNLGEM VMCLEDLINY FAQPEDDMEH EEKQNRLRAL RNRQDLFQEE
     GVLNLILEAI DKINVISSQG FLASFLANDE SGQSWDMISG YLYQLLAAII KGNHTNCAQF
     ANSNRLNWLF SRLGSQASSE GSGMLDVLHC VLIDSPEALN MMRDEHIKVI ISLLEKHGRD
     PKVLDVLCSL CVGNGVAVRS SQNNICDFLL PGKNLLLQTG LVDHVASIRP NIFVGRVEGS
     AIYQKWYFEV TMDHIEQMTH MTPHLRIGWA NTAGYVPYPG GGEKWGGNGV GDDLFSYGFD
     GMFFWSAGRR TCVVPREISE PFIKKGDVIG CTLDLSVPII RFTFNGEPVQ GCFTDFNLDG
     MFFPVMSCSS KLSCRFLFGG DNGRLKFNPP PGFSPLVQCL MPHQNLSLDP CFYFGNLNKN
     VLAGPWLVED DSAFVPKPVD TSSVTLPSSV ETIRDKLAEN IHEMWALNKI EAGWTWGERR
     DDVYRIHPCL TSFEKLPAAE KRYDCQLAVQ TLKTILALGY YISMDRPPAR IRPIRLPNDP
     YMQGNGYKPA PLDLSAAVLT PKMEELVDQL AENTHNLWAK ERIQQGWTYG LNEDSENLRS
     PHLVPYSKVD EAIKKANRDT ASETVRTLLI YGYNLDPPTG EANEALAAEA LRQKFAAYRT
     YRVERTYAVT SGKWYFEFEV LTAGPMREEK VSGGATESFG KQWVPGDIVG VFLDLVDHTI
     SFSLNGELLM DALGGETTFA DVNAPEGVGF VPACTIGIGQ KARVVYGQDV DSLKWFTTCG
     LQEGYEPFCV NMKRPVTHWY TKDQPIFENT DEIPECKIDV TRIPGGADTP PCMKISHNTF
     ETMEKANWEF LRLSLPVTCA NTFISEQEKT RRWDEIRMRQ HRLMTEVDHS APAHFDHIMR
     SGFTMNDIKG LHRNYSEDAA EADEMMRNGP RRPSRHQSRG GLSPPGIEIN GEATSDGELN
     AYSDNELDGV GDERKKRGRS PFRLFGKKRD QSKDKLKDRR TPEPEPRKSN LKVAQRGQAT
     RLSNSDLRAQ PPMVPERKGM GSPQVESFGN EVYDAECLRL INEYFYGVRI FPGQDPTHVY
     VGWVTTQYHV HSKEFGQNKV RHAAIYVEDE NEKTIEIVNR QSCYMVRADE LFNEVTQDSS
     GKGASQGMFV GCFVDTATGT IRFTCEGKET SHVFLMEPDT KLFPAIFVEA TSKEILQIEL
     GRTPTTLPLS AAVLPTSDKH INPQFPPRLK VQCLKPHQWA RVPNTALQVH ALKLSDIRGW
     SMLCEDPVSM LALHIPEEDR CIDILELIEI DRLLQFHAHT LTLYSALCYQ SNYRAAHALC
     SHVDQKQLLY AIQSEYMSGP LRLGFYDLLI SLHLESHATT MEVCKNEYII PLGSELRELY
     IDPEMCHSLR SLQTLSVRPE MNMTEIAPTP SQSNMPTIVA PDSSSEPIPA IDSLYSPRFP
     LEVVREFVMS ALQEAVLINQ VHNRDPIGGS NENLFLPLIK LIDRLLLVGV ITNEDVEKLL
     IMIDPETWDP SFEKEGKDEH RKGLLTMKMA EGAKLQMCYL LHHLYDVQLR HRVESIIAFA
     HNYVGDLQQD QLRRYIEIKQ SDLPSAVAAK KTREFRCPPR EQMNAILGYK NLEEDDLENA
     SCGPELRNRL IEFHEKLMGK VSLNALQEPE EPELDKLEEG KPGALKKLYN FINAVKELEE
     DPKEPEEEEK KTPEEVFRKV LIKQIVSWAE ESQIENPKLV REMFGLLVRQ YDTIGELIKA
     LNKTYVINSK TKGDVANMWV GLSQIRALLP VQMSQEEEEL MRKRLWKLVN NHTFFQHPDL
     IRILRVHENV MAVMMNTLGR RAQAQSDAPV QTADGEESAP KEKDTSHQMV VACCRFLCYF
     CRTGRQNQKA MFDHFDFLLE NSNILLSRPS LRGSTPLDVA YSSLMENTEL ALALREHYLE
     KIAIYLSRCG LQSNSELIER GYPDLGWDPV EGERYLDFLR FCVWVNGESV EENANLVIRL
     LIRRPECLGP ALRGEGEGLL KAIIDANKMS ERISERRKMQ DEAEGTIAGL NFSHPLPEGD
     DDEDYIDTGA AILCFYCTLV DLLGRCAPDA AVIEQGKNES LRARAILRSL VPLEDLQGVL
     SLKFTLTNPA LGEDRPKSDM PSGLVPGHKQ SIVLFLERVY GIETQELFYR LLEDAFLPDL
     RAATMLDRSD GSESDMALSM NRYIGNSILP LLIKHSKFYN EAENYASLLD ATLHTVYRMS
     KNRMLTKGQR EAVSDFLVAL TSAMHPAMLL KLLRKLTIDV SKLSEYTTVA LRLLTLHYDR
     CAKYYGTTGS GQASQFGASS DEEKRLTMLL FSNIFDSLSN MDYDPELFGK ALPCLIAIGC
     ALPPDYSLSK NSDDDLYGKP TGGGPDQPHY NPQPIDTTAV QLTNDLNQIV QKFSEHYHDA
     WASRKLENGW TYGDQWSDAN KTHPRLKPYN TLSEYERERY REPVRESLKA LLALHWRIEH
     SEGDVPLSNR GSMRRQSKPN LGDTGSPFNY NPHPVDMTNL TLSREMQNMA ERLAENSHDI
     WAKKKNEELN QCGGAIHAQL VPYDLLTDKE KRKDRERSQE FLKYLQYQGL KLHKPSRGQT
     EEPGMSTAAI ELRFAYSLLE KLISYSDRAT INMKLLKPSS TFSRRSSFKT CSRDIKFFSK
     VVLPLMEKYF STNRNYFIAI ATATNNVGAA SLKEKEMVAA LFCKLASLLR YRLAAFGADV
     RITVRCLQVL VKSIDAKSLV KNCPEFIRTS MLTFFNNTAD DLGQTIVNLT EGKYDRLRGT
     HLKTSTSLAY VNQVILPVLT SLFDHLAACD YGSDLLLDEI QVASYKILSA LYTLGTDMSL
     TRDRKYLKTE LERHKPALGS CLGAFSSCFP VAFLEPHANK HNPFSLLNRI ADTSLEAQDI
     MSKMESCMPT LESILSEVDQ FVESEKTYQE AQHIIDVILP LLCSYLPFWW NQGPDNVSPQ
     TGNHVTMVTA DHMNHLLKNV LKMIRKNIAN ENAPWMTRIA TYTQQIIINS SEELLKDVFL
     PLAERVKKRC DSMFHKEESL RGFLKSSTDD TSQIEAQIQE DWQLLVRDIY SFYPLLIKYV
     DLQRNHWLKD NVSEAEELYN YVAEIFNVWS KSQYFLKEEQ NFISANEIDN MALIMPTATR
     RSAAVSGDMP ASGGKVKKKK RSRDKKRDKD KEIQSSLMVA CLKRLLPVGL NLFAGKEQEL
     VQHCKDRYLK KMPEYEVIEF ARTQLTLPDK LDPADEMSWQ HYLYSKLGKK EQIVQDTIEK
     TDKKPENKIE DTVERIVAMA KVLYGLHMQT FEDAEKKKKD EEEEEGKPDP LTQLVTTFCR
     GAMTERSGAL QEDPLYMSYA SIVARSCGEE EEEGGDEEEG AGGEDEGGAS IHEQEMEKQK
     LLFHQARLAN RGVAEMVLLH ISASKGVPSE MVMRTLELGI AVLRGGNIDI QMGMLNHLKE
     KKDVGFFTSI AGLMNSCSVL DLDAFERNTK AEGLGVGSEG AAGEKNMHDA EFTCALFRFI
     QLTCEGHNLD WQNYLRTQAG NTTTVNVVIC TVDYLLRLQE SIMDFYWHYS SKELIDPAGK
     ANFFKAIGVA SQVFNTLTEV IQGPCTQNQQ ALAHSRLWDA VGGFLFLFSH MQDKLSKHSS
     QVDLLKELLN LQKDMITMML SMLEGNVVNG TIGKQMVDTL VESASNVELI LKYFDMFLKL
     KDLTSTPSFM EIDSNGDGWI LPKDFREKME QQKSYTPEEI DFLLACCETN HDGKIDYIGF
     VDRFHEPAKE IGFNLAVLLT NLSEHMPNEP RLARFLETAG SVLNYFESFL GRIEIMGSSK
     RIERVYFEIK EANIEQWEKP QIKESKRAFF YSIVTEGGDK EKLEAFVNFC EDAIFEMTHA
     SGLMASDDDG GTVRRDQAFT YISEEEEERA ARDPIKRTIQ AVKDGLSYSM YMISPSNIKH
     QITVLQSKSF PEIVIGFFKM IFYAFYYSGF GVSVVIRYLV NILMSLMRGP AQEEEEPIPE
     AEPSLRALPP LPLEEPPGTV QAFGLDISKE ENGQYRMAPH ESPALSPSSS IEETGESSPE
     DGAGGELTGE GVAPGEQMTL VDLLGGEAAK RAAQERTEAQ KAQEATLASI EAESKKASAE
     TKEPAAVHQI DFSKYTKKCV SYLARNFYNL KYVALVLAFC INFMLLFYKV TTFGDEEEGE
     GSGEGLMGLG SGLGSGLGIL ETGSGGGGEG GSGDGEGEED DPLEKVQVDE DFFYMEHVLR
     VAAILHSLVS LCMLIAYYHL KVPLAIFKRE KEIARRLEFD GLFIAEQPED DDIKSHWDKL
     VISAKTFPVN YWDKFVKKKV RQKYSETYDF DSISNLLGME KTAFAAQEAN EGGGFFHFIA
     NIDWRYQIWK AGVTITDNSF LYSLWYFSFS VMGNFNQFFF AAHLLDVAVG FKTLRTILQS
     VTHNGKQLVL TVMLLTIIVY IYTVIAFNFF RKFYVQEDDD GEEGDRKCHD MATCFVFHLY
     KGVRAGGGIG DEIGDPDGDE YEVYRILFDI TFFFFVIVIL LAIIQGLIID AFGELRDQLE
     SVKEDMESNC FICGIGKDYF DKVPHGFDTH VAQEHNLANY MFFLMHLINK PDTEYTGQET
     YVWNMYQQRC WDFFPVGDCF RKQYEDELGG GGS
//
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