ID A0A182QL01_9DIPT Unreviewed; 1947 AA.
AC A0A182QL01;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 13-SEP-2023, entry version 31.
DE RecName: Full=Discs large MAGUK scaffold protein 5 {ECO:0008006|Google:ProtNLM};
OS Anopheles farauti.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=69004 {ECO:0000313|EnsemblMetazoa:AFAF012337-PA, ECO:0000313|Proteomes:UP000075886};
RN [1] {ECO:0000313|Proteomes:UP000075886}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FAR1 {ECO:0000313|Proteomes:UP000075886};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles farauti FAR1 (V2).";
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AFAF012337-PA}
RP IDENTIFICATION.
RC STRAIN=FAR1 {ECO:0000313|EnsemblMetazoa:AFAF012337-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR EMBL; AXCN02000864; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 69004.A0A182QL01; -.
DR EnsemblMetazoa; AFAF012337-RA; AFAF012337-PA; AFAF012337.
DR VEuPathDB; VectorBase:AFAF012337; -.
DR OrthoDB; 2877432at2759; -.
DR Proteomes; UP000075886; Unassembled WGS sequence.
DR CDD; cd00992; PDZ_signaling; 4.
DR CDD; cd11860; SH3_DLG5; 1.
DR Gene3D; 2.30.42.10; -; 4.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR035537; DLG5_SH3.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR041489; PDZ_6.
DR InterPro; IPR036034; PDZ_sf.
DR PANTHER; PTHR46360; DISKS LARGE HOMOLOG 5; 1.
DR PANTHER; PTHR46360:SF1; DISKS LARGE HOMOLOG 5; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF00595; PDZ; 2.
DR Pfam; PF17820; PDZ_6; 1.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM00228; PDZ; 4.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 4.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS50106; PDZ; 4.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}.
FT DOMAIN 390..490
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 495..549
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1349..1429
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1533..1613
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1790..1932
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
FT REGION 310..373
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 650..679
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 712..748
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 860..886
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 919..954
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1104..1132
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1149..1192
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1226..1291
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1303..1344
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1439..1459
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1489..1526
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 42..69
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 108..308
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 310..335
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 348..373
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 716..737
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 863..886
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1113..1130
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1169..1185
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1238..1256
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1259..1291
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1492..1509
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1947 AA; 210373 MW; 21B9CB04C6567871 CRC64;
MASSENNSDD GGHNVFSGFA SSNGSAPEYE HLLQFEYLKT KYRDVVSQLK AVSNEKQRLE
HDFQLLKKEL EGKGDFFNST YHEYSGLKQK YDTLRLRYDE ITKDPSNCIK LCEELKKERN
KYKELLKATE LELETVLSER GSVLKENQKL YDKNEALERE VQGKQKECTV LKEKIELLKT
RQEYQQLSNE NSWSKELSES KDKLSIVSEN LESANQEIER LKKALDKAKA EIAKAIHDTE
VAKQRRDWAI SEREKIVQER DSVRNLCDEI RKERDTATSK LLAAIRDKDD AHKKIELLTD
QLEQVIRDSI NNNTGTTGGQ GVSTRGNQPQ PNGGSGGSGG GGGGGGGGGT GTSTTPNASM
ASVNNSNSHR NSHYSSFSSI YNMESLQQYD VELVEIDTSP LLSNSSDWGL TISGDLDHHS
YGSDHSTTKN LCGPYVAAVE HDSIFAGKLK PNDIICQINN HDCSTFSRRM IYRTIRNSVP
QCVITVKRPT KRLLPVQIPF TSTNRNHGLC LELGLYIAKL EPNSIAAKDG RLAVGDRILS
INNKPMESIK NINDVHAYIN DMRNSSLNLI VIKEMAEPHP SYASFYQPRL KHIRNTTSCT
QTDNSLSTFG SQHTTSNTSQ SVSTSANAMS LINHHRLSLE LDNTTHFLPS AMPSSSYQPS
SSTPNSITAS TPSSTKSASK LTEFIQKIKD KMAITNHSKD AGQEHDAIAA LDSVLDSDEQ
SREGKRTKRR TKLDSGGTSH HQADVPRGTW PRVNMTIHIN ETHPGTHVHR PKKERPRLAI
PTGGTDGGDL DNNNYFTAVL NEANTIPTNF HQPNPIVGGG VVPVPPKGIP GNRLSVGGIA
SSGGGGGGGG AGGGGSIGGV YGGGGTTSPS GQGTLPSASK RNSNPVIPMD INRLLALKYG
EAGMIGGSGT GGNAMAAATM GKSQTSGGGG GPGGFPRSST YDPDRHHDAG GLNMNKHRFS
LNLSTMTKQQ QQMLLPPHQQ QNSLDFIPIP SAASQKSNHS IDSASASLSK SPPMYYPGPA
SGTATLAIPT SKTTEFFMPS KISKTLSKYS SDNDSLDTET LGGMGQLMLS GISPNKMGPM
NNQQAAGGGV SPGNTNTLPL PQMRKQLMGN SGGHGGGVSS SSNRSGHSAV HPAATTGYGA
TIFPGSYPHP FMRNHHQPGT GGGGGAGTND GYPSNTSSSG GNGVPVPTTI AHHSHGASMD
YSYRYSQIQS SKEDVPIAGY AGGYEGGTFP RNKSHLTSSS SNHHHHHHHH HQHHQNLQGG
GFRIPSNQSV TSRGSGIKIS NGSIDCSSSE RASPIPTFEV QVLKPGHAPS GGGGNAGGGG
GGGSSGVSNK RAGQQDYGQP KPNVGELRLV QIDKSEVSLG IKIYCRSNGG GVFVSNVGEN
SLASKVGLQI GDQLLEVCGI NLRKATYDLA AHVLRQCGNS ITMLVLYNPV VYSNLTTSDD
NLTRSGSPTP QNSPRPIGRS LLSQVTTATA NTMAGAMVAG TPKTSSLAKA KEFSDSLEHQ
THDDEEDGSV VPVGGSVGVS GPPGSMYKEQ PREIYIETHK TSNLGITLVG GNAYGIFVHG
VQKDSIADQA GLLVGDQILE FNGTDMRRST AEHAALEIAK PADHVKVLVL YNIQKFNQIK
DKPGDALYIR VGFDRNCDQG DSELSFAKDE VLFVDNTMFG GIPGKWRAWK LDEYGHKRQC
GIIPNKLKVE EELRLLGDPG DVDTTARRGS TSARRSFFKR IKRTSSRDSK ELASFSNTHL
SLYLESASMG DDGLSSYQRV ERLEYTYRPV IILGPLSEFV IDKLCVDFPE DFAVLQESQK
KCTKEEMELA LQNNTIADYK MRSNGVFEYT SMQAVRDNKQ CHCILNVSMA AVERLQRAQI
YPVVLLLRFK SAKQIKEIKD SRYSTDKISA KAAKEMYEHT LKMESEYRQF ISVVISGVNI
THMCTQIKAA VDSEQKKILW VSIPSPL
//
