ID   A0A182QLA0_9DIPT        Unreviewed;       449 AA.
AC   A0A182QLA0;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   RecName: Full=Etoposide-induced protein 2.4 {ECO:0008006|Google:ProtNLM};
OS   Anopheles farauti.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=69004 {ECO:0000313|EnsemblMetazoa:AFAF012482-PA, ECO:0000313|Proteomes:UP000075886};
RN   [1] {ECO:0000313|Proteomes:UP000075886}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FAR1 {ECO:0000313|Proteomes:UP000075886};
RG   The Broad Institute Genomics Platform;
RA   Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Anopheles farauti FAR1 (V2).";
RL   Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:AFAF012482-PA}
RP   IDENTIFICATION.
RC   STRAIN=FAR1 {ECO:0000313|EnsemblMetazoa:AFAF012482-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the EI24 family.
CC       {ECO:0000256|ARBA:ARBA00010970}.
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DR   EMBL; AXCN02000765; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A0A182QLA0; -.
DR   STRING; 69004.A0A182QLA0; -.
DR   EnsemblMetazoa; AFAF012482-RA; AFAF012482-PA; AFAF012482.
DR   VEuPathDB; VectorBase:AFAF012482; -.
DR   OrthoDB; 315087at2759; -.
DR   Proteomes; UP000075886; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   PANTHER; PTHR21389:SF0; ETOPOSIDE-INDUCED PROTEIN 2.4 HOMOLOG; 1.
DR   PANTHER; PTHR21389; P53 INDUCED PROTEIN; 1.
DR   Pfam; PF07264; EI24; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        90..119
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        139..160
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        181..200
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        212..233
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        254..269
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        275..293
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          38..71
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          326..422
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        349..380
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        381..397
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        398..422
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   449 AA;  50679 MW;  01CA9D56FDD140DE CRC64;
     METLCRVGAT VLHGILDSIK GITVVFYLDK EANRKLSQPT TKPLTVGQTP VRTKESLSTQ
     PRTPSSSSNT LVSKRIEESK VLKRVVQCSI LNGGIFMLSI LFFEYAVMPG LHLFLWWMFR
     NSTTMTTMWG WMQPSLSLLF NSFWVAPLFL LSKIVNSLWF QDIADSAYKF RKGRPQLIPS
     ISKLIADTLI SLLIQILFLL QSTLVKYLPV PVPFACAAIY MVHMSLLCSL YAFEYKWFNM
     GWELHKRLTY IEQNWPYFLG FGLPLAVLSE LPNSIVISGC VFSVLFPLFI ISANEATPKV
     DVCETPLKLF SIVVALTNAL FRGRTKGPGK AALSQPLSPG AGGNMRGLTP PLSASSSAFV
     FQQQQQQQQQ QQQQHYRQHH SSQRQQQHHH HRSQHHRQPS PSPSAASSSF ASSASVQTAQ
     LVHQQQQQQQ QYQTILNRAT MATQRHAKW
//