ID A0A182QQN0_9DIPT Unreviewed; 3599 AA.
AC A0A182QQN0;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=K Homology domain-containing protein {ECO:0000259|SMART:SM00322};
OS Anopheles farauti.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=69004 {ECO:0000313|EnsemblMetazoa:AFAF014940-PA, ECO:0000313|Proteomes:UP000075886};
RN [1] {ECO:0000313|Proteomes:UP000075886}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FAR1 {ECO:0000313|Proteomes:UP000075886};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles farauti FAR1 (V2).";
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AFAF014940-PA}
RP IDENTIFICATION.
RC STRAIN=FAR1 {ECO:0000313|EnsemblMetazoa:AFAF014940-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR EMBL; AXCN02000234; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 69004.A0A182QQN0; -.
DR EnsemblMetazoa; AFAF014940-RA; AFAF014940-PA; AFAF014940.
DR VEuPathDB; VectorBase:AFAF014940; -.
DR OrthoDB; 5480610at2759; -.
DR Proteomes; UP000075886; Unassembled WGS sequence.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0010468; P:regulation of gene expression; IEA:UniProt.
DR CDD; cd22404; KH-I_MASK; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 9.
DR Gene3D; 3.30.1370.10; K Homology domain, type 1; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR047373; KH-I_MASK.
DR InterPro; IPR004087; KH_dom.
DR InterPro; IPR004088; KH_dom_type_1.
DR InterPro; IPR036612; KH_dom_type_1_sf.
DR PANTHER; PTHR23206:SF7; ANKYRIN REPEAT AND KH DOMAIN-CONTAINING PROTEIN 1 ISOFORM X1; 1.
DR PANTHER; PTHR23206; MASK PROTEIN; 1.
DR Pfam; PF00023; Ank; 2.
DR Pfam; PF12796; Ank_2; 8.
DR Pfam; PF00013; KH_1; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 24.
DR SMART; SM00322; KH; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 3.
DR SUPFAM; SSF54791; Eukaryotic type KH-domain (KH-domain type I); 1.
DR PROSITE; PS50297; ANK_REP_REGION; 20.
DR PROSITE; PS50088; ANK_REPEAT; 22.
DR PROSITE; PS50084; KH_TYPE_1; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00117}.
FT REPEAT 489..521
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 523..555
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 556..588
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 589..621
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 623..655
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 656..688
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 689..721
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 722..754
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 756..788
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 786..818
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 819..851
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 852..884
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 886..912
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1588..1620
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1621..1653
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1655..1687
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1688..1720
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1723..1755
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1757..1789
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1790..1822
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1825..1857
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1858..1890
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 2325..2395
FT /note="K Homology"
FT /evidence="ECO:0000259|SMART:SM00322"
FT REGION 1..123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 157..338
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 370..431
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1076..1108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1145..1201
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1468..1499
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1972..2327
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2363..2382
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2409..2458
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2476..2503
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2519..2626
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2640..2754
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2789..3342
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3501..3520
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..56
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 70..123
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 171..185
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 186..201
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 220..268
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 276..290
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 297..329
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 373..412
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 413..431
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1086..1108
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1146..1165
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1187..1201
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2011..2058
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2065..2094
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2095..2141
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2150..2200
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2234..2252
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2268..2288
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2519..2548
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2561..2622
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2640..2689
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2706..2754
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2803..2898
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2935..2980
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2994..3037
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3045..3088
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3183..3197
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3228..3249
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3282..3309
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3599 AA; 370264 MW; B03A9DE179A9B38A CRC64;
MQNVEQSGVK NREKIVKSVN QQTSSKSQLQ QQQHTIPSSS SLSSSCSSTS AEGEKATAFA
SASLGETAPG APAKSSSSTS LKPSKNNSSN SSTIGGGSSS VGSGVVGNSG NSEAISSGAA
ATAATTVDDV ATGVVDVSAP VPSPASLSAA LPAVKDVDGC VGSGVGTSHQ HPRRAEGEGS
DSRHRVSSSR LTPSSGESAE DSADVSGVAG AEHIRPQVPG SDGSSRNNFQ ANNDKTMSST
KSSTTAAKPA LPQPTGAAAS TSGASGGGDG DGSKTAATGG TGSSCVGAPK QPTGGVSAVV
RPNNNKLSSN NSSPAKSDTE TFSEIQPRVS DSSESEEESV SEILLACLCL RPDLLVDSFP
LDQQSIEIPE TECSDSCEND VDMDESDSCD NDADDNDDSE EDDEEEDDDD EDMGHSAAPR
KFLLENDDDT DHERDEAAHA LTRMKSSDGS PRDKNLLSRS LIAACTDNDV NTVRRLLGEG
NSLSEATEEG DSLLSLACSA GYYELAQVLL AMSAQVDDRG QKNDCTPLME AASAGHVDII
ELLFKHGADV NAQSSTGNTP LMYACAGGHE KAVKLLLEHG AKVEDHNENG HTPLMEAASA
GHVGVAKILL DHGAGINTHS NEFKESALTL ACYKGHLDMV RYLLEAGADQ EHKTDEMHTA
LMEASMDGHV EVARLLLDSG AQVNMPTDSF ESPLTLAACG GHVDLAMLLI DRGANIEEVN
DEGYTPLMEA AREGHEEMVA LLLQQNAQIN AQTEETQETA LTLACCGGFI EVAEFLIKNG
ADIELGASTP LMEAAQEGHL DLVRFLLQNG ANVHAQTQTG DTALTYACEN GHTEVADILL
NYGAELEHES EGGRTPLMKA CRAGHWCIVK FLIEHGADVN RHTTNNDHTP LSLACTGGHQ
SVVELLLKNN ADPFHRLKDS STMLIEAAKG GHIGKAKIQF ISDVKGPPST LLPPMETYIN
IASPNMQAGK PIIDGNSNNG ALFFASTLSG NLPQPQHLQL ATIAANAASA APASVIPSSE
ASVQMLQQSM ANLNLQSQSP VMASSTTTVQ SVGTLLSGGK SSEVKTFGTV ATAANEAKKS
DVNDATDTKP SVSATGSVKS IPKPSANNST VITSATAAKR AVAATPAAAT VAKDAAVDVV
EAVSSNVKEK RQSSSSNSSS VVSGGVTDEE VAPAAAPAVP SGDSVTADGS DGASSSSSTS
DLEYPELSRI LCSFSRSDIL PAPEFVQVHQ HMQNIIQHKG SSNPIKLGDA SDGHQYAEEG
EEHLSMFNIE ESEGDGMAEC VGGMYPSLDE TLEPFHGEDG SVAQAHGSRE SMYNYEWVDS
IDDVIHVLNG CPDIPMALHD MAANFSCQDI DMYANLIGLN SFCKTRWAGN QNQLTSGTSS
PAEEDGSNAV ALSDEQCAYR QGQAAASQLL TFDPQQFSMD QIQLLNQFHQ ASASGSAVLH
HPASGAGSDG QQPKLVFNVD ADKASQTVGV GGKMGGGGGA GVTGGGGGKK GEKNRKEKNR
LTVPPAVRQA PAGQQSGGQQ LANYQYDTNG GRGAGSGGGS AVMDVPPPGS AAAGTVQPFH
GAGGVIAQQA GSVVTERTID VDSETDSNHD TALTLACAGG HEDMVELLIN RGANIEHKDK
KGFTPLILAA TAGHEKVVDT LLRSGAEIEA QSERTKDTPL SLACSGGRYE VVELLLSMNA
NREHRNVSDY TPLSLAASGG YVNIIKLLLQ HGAEINSRTG SKLGISPLML AAMNGHVAAV
KLLLDMGSDI NAQIETNRNT ALTLACFQGR HEVVSLLLDR KANVEHRAKT GLTPLMEAAS
GGYIDVGRVL LDKGADVNAA PVPSSRDTAL TIAADKGHLK FVELLLSRGA LVEVKNKKGN
SPLWLAANGG HLGVVEMLCT AGGDIDSQDN RKVSCLMAAF RKGHTKVVKW MVGQVTQFPS
DQEMTRYINT ISEQELLEKC HDCVKVIRAA KDQQATKANI NASILLKELD LERSREESRK
AAAAKRRERK KRRRAEKREQ QRKLEMGEEG GEAGDGQDDE DEDEEADEDK EEEEEEEEEE
EEEEEEEEEE EADSEHDEDE LLLSAAMIQQ SSAAGNKHKN RNVNNAQLHS NSKSQQQNHR
EKERESRRLQ EKEHLQQQCA GRDNGKREKT LEKENVAPRD HDGRTGASAG GATKNESKKS
SSASGNNDHH HHQNGPQQTG ATHQHQQQQQ HQSNAAGNRK SIIVFGSGNR HAADQNDDQQ
NFYHAGGALG SGTGGKKTHS QKTFYNTTTN NDDHHHGGGH HGKMASSASP MKQHQQAGLQ
QHNGSQPNAM GGGAKREEGW KEVVRKSSVQ QGGGGGGGGG SSSSPMECRK VQVPVHAISR
VIGRAGSNIN AIRAATGAHI EVEKQGKSQG DRSITIKGSQ EATKQAHSLI VTLIKDPDVD
ILLMLPKHNT TAGSSSQKTY GSSSANSGGG SGSSSTAGQS SGGGSSSGTG TVPAQPPAII
SSNASAARPP AAKNLFLSSS NSSTQQHQQT SSRVMTAGSS NNGVVPNSVP YAVAASSSAS
QVKDSKRQPA ASGGIQQQQQ QTIGTKGGSQ HHHPGLATSG PSGAGGNSTA TPPFGSVGMK
PKNTSNVNKP TPQNTANASV PLNSGINGGG VGNTSSGTTG APAATPAAPM AGSFAKLVAS
DNHQKKSSPS VGPIGVASGQ QQQQQQSGTG VTTGRGGPTP MQVQQSPAKS GGAGPPGGLP
VPFAGGSSNS AAQSTAAPGP IGSHIISSNS HPQTSATATA SVGGGGSGNT GQQQKISSFI
PPIATTGPGP TIVEASAIPP LPPISVPNTA NPLAAPGSGR SITPIGQPPS SASSAASTSA
VSSITTISTA SSSSGSVTGP IGSRAVTTPS PLLHQQQTSG SSITSATVGG QLHAKMQAIG
QQQHHQQLAP SPPPSNVYSL FNDPGVGGAG TSGVLGPFME NPPTLQVDAS KAPGYRGNTI
SSPVSSKASS NATTPPSSSM SSHQHQQPPP LHQALQHQAN GGQHGGPMHH PPHTLQQQHP
SLGLAHMLSA GSSSSTSPLS GLGGQQPPPT VVSRDSGVIN IVSGGGGHSV SSASASVPTS
TVAGGPHQQQ QPTSYQSSND SSNVGMKPNA PPPSMLGGGG AAGSNNQGGG LGMLRSMMNL
TSHMRPPVGG NGPPDFLGGS SGGGGGRDHA SGMVPQPQPP VGSSRPPPPL MFDNVGSLGS
GGPPDALQSS YQQHLGGLGG SGNAGLPPIS RLNPKASAFA GGIGPSIMPP SQQHQPGKMN
LSNNHPPYGG GNSVGAGAGM FHTPPPIGLG SGGGGSGGGG GGTSGKYTSM SSYSLAPGRP
NNQQQHGGSG AGGPPPPVGT IHHRGGVGSG GGSSGGNNWY SSDLSHLQRD NLMGMENGLA
MALNAASPTI SPNNNNAQQQ HAINGGLMTP HQQQSQQQSM MDDARKQLPR AIGTERAWKF
GGNGNVGPIG SGGGGVGASG ANNTSSGGNM YNAAMVSAYV GLDGADLMNG SGASPAALAA
AAAAASGNQP WMNIDKNQFM AGSGGGGVGG GSQQQHQQQP PLPWLTMGRQ YMDDIHLPDH
FQQLQMDYHG NIGGSGPNQP NMNFMQYPFT PSNDMVGTGD LRPPWEHEKQ GWSQKWSGH
//
