ID A0A182QTC3_9DIPT Unreviewed; 3067 AA.
AC A0A182QTC3;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=Histone-lysine N-methyltransferase {ECO:0000313|EnsemblMetazoa:AFAF016439-PA};
OS Anopheles farauti.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=69004 {ECO:0000313|EnsemblMetazoa:AFAF016439-PA, ECO:0000313|Proteomes:UP000075886};
RN [1] {ECO:0000313|Proteomes:UP000075886}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FAR1 {ECO:0000313|Proteomes:UP000075886};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles farauti FAR1 (V2).";
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AFAF016439-PA}
RP IDENTIFICATION.
RC STRAIN=FAR1 {ECO:0000313|EnsemblMetazoa:AFAF016439-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; AXCN02001534; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 69004.A0A182QTC3; -.
DR EnsemblMetazoa; AFAF016439-RA; AFAF016439-PA; AFAF016439.
DR VEuPathDB; VectorBase:AFAF016439; -.
DR OrthoDB; 5490909at2759; -.
DR Proteomes; UP000075886; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0043933; P:protein-containing complex organization; IEA:UniProt.
DR CDD; cd19170; SET_KMT2A_2B; 1.
DR Gene3D; 3.30.160.360; -; 2.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR034732; EPHD.
DR InterPro; IPR003889; FYrich_C.
DR InterPro; IPR003888; FYrich_N.
DR InterPro; IPR047219; KMT2A_2B_SET.
DR InterPro; IPR003616; Post-SET_dom.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45838:SF4; HISTONE-LYSINE N-METHYLTRANSFERASE TRITHORAX; 1.
DR PANTHER; PTHR45838; HISTONE-LYSINE-N-METHYLTRANSFERASE 2 KMT2 FAMILY MEMBER; 1.
DR Pfam; PF05965; FYRC; 1.
DR Pfam; PF05964; FYRN; 1.
DR Pfam; PF00856; SET; 1.
DR Pfam; PF13771; zf-HC5HC2H; 1.
DR SMART; SM00542; FYRC; 1.
DR SMART; SM00541; FYRN; 1.
DR SMART; SM00508; PostSET; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS51805; EPHD; 1.
DR PROSITE; PS51543; FYRC; 1.
DR PROSITE; PS51542; FYRN; 1.
DR PROSITE; PS50868; POST_SET; 1.
DR PROSITE; PS50280; SET; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 812..920
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS51805"
FT DOMAIN 2929..3045
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT DOMAIN 3051..3067
FT /note="Post-SET"
FT /evidence="ECO:0000259|PROSITE:PS50868"
FT REGION 1..148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 411..462
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 545..572
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 605..639
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 734..770
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1187..1216
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2078..2097
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2137..2180
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2364..2388
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2463..2493
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2518..2546
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..53
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 85..148
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 411..431
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 438..458
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1187..1211
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2463..2483
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2523..2542
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3067 AA; 329389 MW; ECDC5BC6FB9F2639 CRC64;
MAATTSTPTA TISGTCEVGS SIGNGHQQSS QQEQQQQQQQ HQQSSQNSNC GARNEKHPAA
GNGFEMKPST LTSALARRCP PTVASGRVSR QQSPSCEQGA TENSSSGSNP SATGITTSSR
VPKVDETTEQ STTVGVGGTG STSSKASALM GSKPLTAAST PAAVSTVASI APVKKKSVTF
HTTLETTDEN IVKKVYNPDT VPLPSIIKKE CLDRPIRLKK SFNRKMKKRL QRAVAAAAAA
AAAASTSASS AVGGASGAAK TMECLVRPSR LTEIMLKSSN KPSTGGGVAM SLDRSSGSVG
GLGFGLKALE SAKSGLAFGT SRETGAQAVA ITTEAGSDAI GRNLESGGTQ FGDKRFILPK
RSVHSSRVIK PNKRFLDEFE LEIKKKNKNL AAAAAVAAAA AAAEACSTTG TGSISSASAS
KENTTLDSAG ADGNDADSVI GEETRKKKDK KKCEESADKP SSIAIPGVTS TLSSTTTNTT
NLSAAASIFG KGILRQPRLQ FATSLLNNNN TADKRQRIDL KGPRVKHVCR SASIVLGQPL
ATFPEDGSAD APSGEVVNIE TPPSDSAAEP GEDLPLIDRE RHASVNDSST VKQDCSDCID
PTMALSPPAT PDEVTGAVRA SPAKPEIVPS FDPDTSGSTE KELMIDEDQL PDVEDEKECS
RKTGGDISLV DIKQKINANE YYSLQDFHYD MNTLLQAVSS EELTVAYKEF LSETFPWFQN
ETKACTDALE EAMRGEVDQS SSLDRYHSST RTGAMGGDRG GSTDSHNGTS HQLRNNMYPF
ATTLDQKVPQ VDIPLDDLSD YFHGSEEELL DTRICMLCKQ QGEGMPLHES RLLYCGQNNW
IHTNCALWSA EVFEEIDGSL QNVHSAVSRG RLIKCCHCGV KGATVGCNVK NCGEHYHFPC
ARHIGCVFML DKTVYCTSHA IEAQKKRCPE ERNFEIARSV YVELDRRKKR FVEPSRVQFM
IGSLNVRRLG HVVPTFSDHT DVLIPTDFEC TRLYWSAKEP WKIVSYRIKT SIQSSNYCYG
TDLGKNFTVD HSSNSSTVQW GLTQIARWHT SLQYCEDQQE EMVDTLDNEA LQQHLISSMS
STATTMTTTT TTQLLASSRC EPNTVCVGTG DDTNDEEPQN TNDLLPPEIK DAIFEDLPHD
ILDGISMLDI LPKLMTYEDL LAMDLKSDST FNIDILKDPG ILQGLGNGAG SSTGGSSTTA
NNVGQSAKNN DHSGMDVEDM TSLHEAIGST VGSELSNDSW AKTIGTPGVE DALLSGLTKP
ATPSVTNTAV HHRELKRSKS DILEAIAAAG QQQPRGQRSG SFSWNTKQLE STAAAVAKRR
KIASPITLPH SLASGTGPMT TTTLSTAQGL GGVFSQQPQI FSIGPNGQPQ LMTIAAPQHQ
QTILQAGVSQ PIGMQQGAKK IVYTTASPKK VMTKLAQQQQ GLKSKRTLAS NGVSKPGIQI
KTKQQQHQEQ TVTLHPTTNV IGGQSTASQL QTTLTAAPQQ QQQQQIQLIN TSYPLIQRAT
APTGPHQTSG NVIFQTQSPS NQPILVQQVG GNQISYLADQ GTLTANPVQY QLAPANVLTQ
NGFAMATTGP DAGTLAAATA NNILIPNGTG GYSLIPAGAL QIATQPQVIG TIVQPQAAAI
QCGMMATEQM VLGATAAATA SAQPTLEMMV TDPASGCMYL TSPSMYYGLE TIVQNTVMSS
QQFVSATAMQ GVLSQNSSFS ATTTQVFAAS KIEPIVEMPT GYVVLNNDGT TAQQMQIGTS
TASVVSQAPT PVQMQTSTSV GANGGQAIFQ QAQLQPTAAV VSSSASGSLP TAHQTTPVVS
IQQQQQQQQL WKLECSTPST ISIQPNTIAT SSSNSTTSIV TPLKPTMKTI VPKSQPQLVN
KVMPNTAMKV LSSGNEQTST GTGSMVSVSQ QQKSACFQSI VSSSVYTTAT ALTTSTKVSN
VIKPITKTTN YTKPKIVAKP VKQKTSPALL SPTSHSPVYQ LSQQQPPTVM ISTQPVQQQQ
QQLLQNGITL IPATSTSTPV NNASQLVPIK PNVNANGLQT ITANQLTVSA IAQQPPIVIE
KLPQQVQSVT SSTSVTPISN GISLNNGQMM IIQPNSASVA KKPTQVNGQG SGHVKKQKTM
LPMNQISYTT AQQLPQQQQQ QQQQQAQPYQ QLMNVSTTQQ QLSGIPQQQQ QQQGQQQQIQ
SQPIGISQGG KGPLSKKTSS NVGQITLSLA NIGTTNTIGP VPVSMPASTI TITPSQPASI
TLPTAPYPMP LYSNIPTNVV NPIQQQTNQN TQSSTGNSRP TNRVLPMQAS VMQQKNPEVP
QTPPPPPLKM LHQQCSEKLD HEFSIIPSPA PFGVSTPSSS PNDVDRMKMS GNEKLLTTGK
NTNRLEIEIK PIEITPLTSA MMTPTTTNGS CTPSPLPPSS ISQQQEESSL QTELPLEQAT
MMMEIEEQHQ QQQLHQLNTE QQINETPSFQ FSLSFDGTSG TLIPLDSQQQ TMTAQIEIKP
ILTSSPRCND GEMQSPQPIL TSNDSIEDDR DTETQRIDEL KHSLEAETQE MLAEGHETSM
CGDSAGAGSS SGTASPSLND GESDSPEIKD KISEILDNLE QQTNQEVEMQ MQAFDSLGGS
KEHCSAVTER LVAELREEFH SAVSSPSTAT PAATVPIMSV EQSQTTANLS DQQNLLTMSD
SMFDNSKKES NINACYRDNI DRSNYAGNTS GDDLNSLLQD GDAESVLFGK IRQPEPSPLS
QPSPTEHHHQ LHQLDEELQQ FTVQAPTPAP PSAATKPPRS TSPKLLYEIQ SQDGFTYKST
SIVEIWDKLF EAVQTARRAH GLTPLPEGQL KEMAGVQMLG LKTNAIRYLL EQLPGVEKCS
QYSPLYHKKQ SSGLGGLGVG ETGTGLAGCN GVADYFDELQ ENVNGTARCD PYKTRSEYDM
FSWLASRHRK QPMPIVAQNI DDTIIPRRGS GSNLPMAMRY RTLKESSKES VGVYRSHIHG
RGLFCNRDIE AGEMVIEYAG ELIRSTLTDK RERYYDSRGI GCYMFKIDEN FVVDATMRGN
AARFINHSCE PNCYSKVVDI LGHKHIIIFA LRRIVQGEEL TYDYKFPFED VKIPCSCGSK
KCRKYLN
//
