ID   A0A182QW63_9DIPT        Unreviewed;       832 AA.
AC   A0A182QW63;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   RecName: Full=Neurotransmitter-gated ion-channel ligand-binding domain-containing protein {ECO:0000259|Pfam:PF02931};
OS   Anopheles farauti.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=69004 {ECO:0000313|EnsemblMetazoa:AFAF018081-PA, ECO:0000313|Proteomes:UP000075886};
RN   [1] {ECO:0000313|Proteomes:UP000075886}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FAR1 {ECO:0000313|Proteomes:UP000075886};
RG   The Broad Institute Genomics Platform;
RA   Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Anopheles farauti FAR1 (V2).";
RL   Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:AFAF018081-PA}
RP   IDENTIFICATION.
RC   STRAIN=FAR1 {ECO:0000313|EnsemblMetazoa:AFAF018081-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
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DR   EMBL; AXCN02001858; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A0A182QW63; -.
DR   STRING; 69004.A0A182QW63; -.
DR   EnsemblMetazoa; AFAF018081-RA; AFAF018081-PA; AFAF018081.
DR   VEuPathDB; VectorBase:AFAF018081; -.
DR   OrthoDB; 22547at2759; -.
DR   Proteomes; UP000075886; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005230; F:extracellular ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR   CDD; cd07401; MPP_TMEM62_N; 1.
DR   Gene3D; 3.60.21.10; -; 1.
DR   Gene3D; 2.70.170.10; Neurotransmitter-gated ion-channel ligand-binding domain; 1.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   InterPro; IPR041871; MPP_TMEM62.
DR   InterPro; IPR006202; Neur_chan_lig-bd.
DR   InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR   PANTHER; PTHR14795; HELICASE RELATED; 1.
DR   PANTHER; PTHR14795:SF0; TRANSMEMBRANE PROTEIN 62; 1.
DR   Pfam; PF02931; Neur_chan_LBD; 1.
DR   SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
DR   SUPFAM; SSF63712; Nicotinic receptor ligand binding domain-like; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        6..28
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        448..470
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        630..652
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        659..680
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        686..709
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          509..585
FT                   /note="Neurotransmitter-gated ion-channel ligand-binding"
FT                   /evidence="ECO:0000259|Pfam:PF02931"
SQ   SEQUENCE   832 AA;  96513 MW;  9CC37CAA1B3B8A75 CRC64;
     MRFTTVAFSL IVFIVIFSIF VANLASLIGI DKQFSNRLDA ASNDGQQRQQ QRLKLDDQHK
     HLMWFLQVSD IHISMYLDPA RVPQLVEFCN RTVDIIAPSV VLASGDLTDA KTSNFLGSQQ
     HEQEWRWYHE VLRDTNVLNK TVWLDIRGNH DNFNVPALQT RQDLFTNYSA QGRHHTRSYM
     HQVSVGGERY TFIAVDACLD PGPKRPFNFV GMLSRNETQH LINIAERSRE LDTNYTIWFG
     HYPTSCILTP GLGSGGIRNL IGRYREAYAY LSGHFHTLGG AVPRMYTLQE EGFLELELGD
     WMRNRRYRLA AFDHGLFSFV DVHHNQWPVV LVTNPKDALF VIPGKEDLDS IMDSTHIRLL
     VFSPAKIAEC QVKIDDHNWQ DCKQTSRQLF VVPWEPSRYK RGFHKLLVYV LDTDGRSRVI
     EQQFTLDGSR LQFDFLAKLV LMYDTNKIFQ TFFSVALIIY LVPLCVFRIW HTLVRPVSVP
     IYNDYTRGIM TQHNGTDHLF RHHPRYLRSP HFAIRRSAHI QSTKQCKRVK SHLSYDGEVI
     YTVLCTFSVD CYHEARYWAF DTRICTLRIY SVEYDTNQLS LFHFQRRLSY PSYPLLPYKI
     TSFQMATVNS TMSPEFRMDI VIERLIGSHL VVFLVLILIF CLLNLISLWF SVESSGRTIT
     IVLGTVMQCV FLVILYWYGV VKMKPVIALA HLLLGTFTFG AIAFGWTYYV RGHIRTKNGF
     VARCPRTVAR MIGFLRKNRP LALFLAIGYL DETSKSSKFA HGWEDTAAVD RNVQPPHCLE
     DDEMNCTAHE EQEDEEENES DVKWTDAVQP IDRIIFCSML TAYLLMFTVY IF
//