ID A0A182QXG8_9DIPT Unreviewed; 2171 AA.
AC A0A182QXG8;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE RecName: Full=U5 small nuclear ribonucleoprotein 200 kDa helicase {ECO:0000256|ARBA:ARBA00034541};
OS Anopheles farauti.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=69004 {ECO:0000313|EnsemblMetazoa:AFAF018820-PA, ECO:0000313|Proteomes:UP000075886};
RN [1] {ECO:0000313|Proteomes:UP000075886}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FAR1 {ECO:0000313|Proteomes:UP000075886};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles farauti FAR1 (V2).";
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AFAF018820-PA}
RP IDENTIFICATION.
RC STRAIN=FAR1 {ECO:0000313|EnsemblMetazoa:AFAF018820-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR EMBL; AXCN02001526; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 69004.A0A182QXG8; -.
DR EnsemblMetazoa; AFAF018820-RA; AFAF018820-PA; AFAF018820.
DR VEuPathDB; VectorBase:AFAF018820; -.
DR OrthoDB; 57056at2759; -.
DR Proteomes; UP000075886; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProt.
DR CDD; cd18019; DEXHc_Brr2_1; 1.
DR CDD; cd18021; DEXHc_Brr2_2; 1.
DR CDD; cd18795; SF2_C_Ski2; 2.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 2.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR Gene3D; 1.10.3380.10; Sec63 N-terminal domain-like domain; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041094; Brr2_helicase_PWI.
DR InterPro; IPR048863; BRR2_plug.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004179; Sec63-dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR47961; DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED; 1.
DR PANTHER; PTHR47961:SF4; U5 SMALL NUCLEAR RIBONUCLEOPROTEIN HELICASE; 1.
DR Pfam; PF21188; BRR2_plug; 1.
DR Pfam; PF00270; DEAD; 2.
DR Pfam; PF00271; Helicase_C; 2.
DR Pfam; PF18149; Helicase_PWI; 1.
DR Pfam; PF02889; Sec63; 2.
DR PIRSF; PIRSF039073; BRR2; 1.
DR SMART; SM00382; AAA; 2.
DR SMART; SM00487; DEXDc; 2.
DR SMART; SM00490; HELICc; 2.
DR SMART; SM00973; Sec63; 2.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR SUPFAM; SSF158702; Sec63 N-terminal domain-like; 2.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 2.
DR PROSITE; PS51194; HELICASE_CTER; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 517..700
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 711..948
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 1364..1540
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 1573..1781
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 51..76
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 214..244
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 376..401
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 216..240
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2171 AA; 246697 MW; 18FB40A7480AD50B CRC64;
MADAAARQLQ YEYKANSNLV LQADVRLIER PRRDEATGEV ISLVGKLDGT RMGDRAQRSK
PEKTEERKAK RQKRDEAQYD FNSMKGATLL SEGIDEMVGI VYRPKTQETR QTYEVLLSFI
QEAIGDQPRD ILRGAADEIL AVLKKDRMKD REKKREIDGL LGTVADERFA LLVNLGKKIT
DFGSEAATAI GGAGQAGPGG DEPIDETYGI NVRFEESEEE SDEDKYGEVR EDDGQDEGEE
ARDDGILHAE NLGGGEDMNK KEKALDPRDI DAHWLQRCLR KYYNDSMTSQ SKALEVLSVL
KESSDDRECE NQLVILLGFD CFDFIKQLKK NRQMILYCTM LAQSQCESDR AKIRERMKAD
AALAKILRQL DTGKQEVQEG RDYANGGADG SESKPSLRSR REDGIMDDME EKMGGGSGGD
RSAAGQGQIV GNRNVLELDE LAFTQGSHLM ANKRCQLPDG SFRKQRKGYE EVHVPALKPR
PFDEDEELIA IEKLPKYVQP VFNGFKTLNR IQSRLYKSAL ESDENMLLCA PTGAGKTNVA
LLAMMREIGK HINDDGTINV DEFKIIYIAP MRSLVQEMVG NFGRRLATYN LTVAELTGDH
QLSREQIAAT QVIVCTPEKW DIITRKGGEK TYTQFVRLII IDEIHLLHDE RGPVLEALVA
RTIRNIETTQ EDVRLVGLSA TLPNYQDVAT FLRVRPETGL FYFDNSYRPV ALEQQYIGVT
EKKALKRFQV MNDIVYEKVM EHAGRNQVLV FVHSRKETGK TARAVRDMCL EKDTLGSFLR
EGSASLEVLR SEADQVKNQE LKDLLPYGFA IHHAGMTRVD RTLVEDLFAD RHIQVLVSTA
TLAWGVNLPA HTVIIKGTQV YNPEKGRWVE LGALDVLQML GRAGRPQYDT KGEGILITNH
SELQYYLSLL NQQLPIESQL ISKLPDMLNA EIVLGTVQNV KDAVTWLGYT YLYIRMLRQP
TLYGVSIDAV QEDPLLEQFR ADLIHTAAIR LERSGLIKYD RKSGHLQVTE VGRIASHYYC
THDTMLTYHQ LLKPTLSEIE LFRVFSLSGE FRNITVREEE KLELQKLMER VPIPIKESME
EPSAKVNVLL QAYISQLKLE GFALMADMVY VTQSASRLLR AIFEIVLHRG WAQLADKCLT
LCKMIDRRMW QSMSPLRQFR KMPEEIVKKI EKKNFPWERL YDLEANEIGE LIRVPKLGKT
IYRYIHQFPK LELSTHIQPI TRSTLRVELT ITPDFQWDEK VHGQSEAFWI LVEDVDSEVI
LHHEYFLLKA KYCTDDHLVK FFVPVFEPLP PQYFLRIVSD RWIGAETQLP VSFRHLILPE
KNLPPTELLD LQPLPISALR DPSFEALYTD RFPQFNPIQT QVFNAVYNSE DNVFVGAPTG
SGKTTIAEFA VLRLLSQNPA GRVVYLVARD PLADLVFHEW HQRFGQSSLG CKVVKLTGET
GTDLKLIAKG QIIITTADKW DVLSRRWKQR KNVQNVQLFI VDELQLIGGE DGPVLEVACS
RMRYISSQTE QPIRIIALSA SLADARDIAQ WLGCGTNATF NFHPSVRPIP LELHVQGLNI
THNASRVAAM SKPVYNAITK FSPHKPVIVF VTSRKLARLT AIDVLTYCAA EMQPNRFFHA
EEDDIKPFLD RMTDKTLKET LSQGVAYMHE GLTASDQRMV EQLFDSGAVQ IAICTRDLCW
ALNISAHLVI IMDTQFYNGR SHSYDDYPIT DVLQMIGRAN RPLDDDDAKA VLMCQSSKKD
FYKKFLNEPL PVESHLDHRL HDHFNAEIVT KTIENKQDAV DYLTWTFLYR RLTQNPNYYN
LQGVTHRHLS DHLSELVEST LSDLEQSKCI GVEDEMDALP LNLGMIAAYY YINYTTIELF
SLSLNSKTKI RGLLEIISSA AEYEDLIVRH HEDNILRSLA SRLPNKLTGP NGTAPKYNDP
HIKTNLLLQA HLSRLQLGAE LQGDTEQILG KAIRLVQACV DVLSSNGWLS PAVAAMELAQ
MVTQAMWSKD SYLKQLPHFT AEIIKRCQEK GIETVFDIME LDDDDRTRLL QMTDQQMSDV
ARFCNRYPNI ELTFAVLDKD RIHSGSSVDV EVTLEREDDV SGPVIAPFFP QKREEGWWVV
IGDPKTNSLL SIKRLTLQQK AKVKLNFVAP SPGHHEYTLY YMSDSYLGCD QEYKFSINVG
DFQSESESES D
//
